| UniProt ID | PRP22_SCHPO | |
|---|---|---|
| UniProt AC | O42643 | |
| Protein Name | Pre-mRNA-splicing factor ATP-dependent RNA helicase prp22 | |
| Gene Name | prp22 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 1168 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Acts late in the splicing of pre-mRNA. Required for the splicing of introns with a branch nucleotide to 3'-splice site distance greater or equal to 15. Mediates the release of the spliced mRNA from spliceosomes.. | |
| Protein Sequence | MDDLKELEYLSLVSKVASEIRNHTGIDDNTLAEFIINLHDQSKNYDEFKNNVLSCGGEFTDSFLQNISRLIKEIKPKDDIPTDNVNNGSNSVNGASHDLDSKDVDKQHQRKMFPGLSIPNSTNNLRDRPALMDNAMDELEELSTLAKTRRNDRDSRRDERHYLNGIRERRERSISPSFSHHSRTSISGQSHSSRSSRGPLLNAPTLYGIYSGVVSGIKDFGAFVTLDGFRKRTDGLVHISNIQLNGRLDHPSEAVSYGQPVFVKVIRIDESAKRISLSMKEVNQVTGEDLNPDQVSRSTKKGSGANAIPLSAQNSEIGHVNPLETFTSNGRKRLTSPEIWELQQLAASGAISATDIPELNDGFNTNNAAEINPEDDEDVEIELREEEPGFLAGQTKVSLKLSPIKVVKAPDGSLSRAAMQGQILANDRREIRQKEAKLKSEQEMEKQDLSLSWQDTMSNPQDRKFAQDVRDSAARQLTSETPSWRQATRNANISYGKRTTLSMKEQREGLPVFKLRKQFLEAVSKNQILVLLGETGSGKTTQITQYLAEEGYTSDSKMIGCTQPRRVAAMSVAKRVAEEVGCRVGEEVGYTIRFEDKTSRMTQIKYMTDGMLQRECLVDPLLSKYSVIILDEAHERTVATDVLFGLLKGTVLKRPDLKLIVTSATLDAERFSSYFYKCPIFTIPGRSYPVEIMYTKQPEADYLDAALMTVMQIHLSEGPGDILVFLTGQEEIDTSCEILYERSKMLGDSIPELVILPVYSALPSEIQSRIFEPAPPGGRKVVIATNIAETSLTIDGIYYVVDPGFVKQSCFDPKLGMDSLIVTPISQAQARQRSGRAGRTGPGKCYRLYTESAYRNEMLPSPIPEIQRQNLSHTILMLKAMGINDLLNFDFMDPPPAQTMIAALQNLYALSALDDEGLLTPLGRKMADFPMEPQLSKVLITSVELGCSEEMLSIIAMLSVPNIWSRPREKQQEADRQRAQFANPESDHLTLLNVYTTWKMNRCSDNWCYEHYIQARGMRRAEDVRKQLIRLMDRYRHPVVSCGRKRELILRALCSGYFTNVAKRDSHEGCYKTIVENAPVYMHPSGVLFGKAAEWVIYHELIQTSKEYMHTVSTVNPKWLVEVAPTFFKFANANQVSKTKKNLKVLPLYNRFEKPDEWRISKQRKGGR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 89 | Phosphorylation | TDNVNNGSNSVNGAS CCCCCCCCCCCCCCC | 28.23 | 27738172 | |
| 91 | Phosphorylation | NVNNGSNSVNGASHD CCCCCCCCCCCCCCC | 20.75 | 21712547 | |
| 173 | Phosphorylation | IRERRERSISPSFSH HHHHHHHCCCCCCCC | 23.75 | 29996109 | |
| 175 | Phosphorylation | ERRERSISPSFSHHS HHHHHCCCCCCCCCC | 18.75 | 28889911 | |
| 177 | Phosphorylation | RERSISPSFSHHSRT HHHCCCCCCCCCCCC | 32.37 | 29996109 | |
| 398 | Phosphorylation | LAGQTKVSLKLSPIK CCCCEEEEEEECCEE | 22.72 | 25720772 | |
| 402 | Phosphorylation | TKVSLKLSPIKVVKA EEEEEEECCEEEEEC | 24.00 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PRP22_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PRP22_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PRP22_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| FAM50_SCHPO | xap5 | genetic | 22681890 | |
| RTF2_SCHPO | rtf2 | genetic | 22681890 | |
| YIW4_SCHPO | SPAC694.04c | genetic | 22681890 | |
| SNF5_SCHPO | snf5 | genetic | 22681890 | |
| YF19_SCHPO | atd1 | genetic | 22681890 | |
| TLS1_SCHPO | tls1 | genetic | 22681890 | |
| MU151_SCHPO | mug151 | genetic | 22681890 | |
| SDE2_SCHPO | sde2 | genetic | 22681890 | |
| ARV1_SCHPO | arv1 | genetic | 22681890 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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