ENT1_SCHPO - dbPTM
ENT1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ENT1_SCHPO
UniProt AC O74423
Protein Name Epsin-1
Gene Name ent1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 702
Subcellular Localization Cytoplasm . Membrane
Peripheral membrane protein . Localizes in a punctate pattern. Colocalizes with F-actin.
Protein Description Binds to membranes enriched in phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Required for endocytosis and localization of actin..
Protein Sequence MKAAVRSVKNFSKGYTDTQIKVRNATTNDSWGPSGTAMAEIAELTYDQNEMLEVMDIIDRRLNDKGKNWRHVFKSLSLLEYCLHNGSENVVRWAKDNIYIITTLREFVYVDDNGHDQGQNVRTKAKEITSLLEDEHALKEARGDSRERDRDRDRTRSSRFDDDDDDRAPYEESRLSRAPSRASRYDDDDRDHRSRRRSRSRRPGRSRSRRRSRRPSPSAEHNSAEENDPELQRVIEESKRQAEEDAKRRNMANDSEAELQKAIQLSKEEDEARQRHQREREQQEQAFMGNQQNAYQPVDFFGNPVQPQPTGFLQQQPTGFIRPQNTGFVQPQYTGFVQPQHTGFVQPQATGFMQPQRTGFVQPQATGFVQPQATGFVQPQATGFMQPQRTGFVQPQATGFMQPQRTGFVQPQATGFMQPQRTGFVQPQATGFIQPQRTGFVQPQQNGFFNPQPTGYMQPQRTGMMQPQRTGFSQPFESNNPFPVMQPQRTGFGQTPNAPMMAPNHTGYVHPQPTGLQRQTTGYTGNNNPYSRPLQSQSTGILQQQQQQSAPRLEPTKTGSNNPFAQFSNLPSQSTAPATKPMKPVRTGDDRFSNIAQAISTGNPMGTDSFGNIGLTRVPTQHTGSKFTNSAGQTIQAQATGNTHNPFQSQQATGYYKQPMQQQQNMQQPYYNQQNYNYQNQQPMQGMQQQSMQPQVGSLIDL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
176PhosphorylationPYEESRLSRAPSRAS
CHHHHHHHCCCCHHH		35.0029996109
212PhosphorylationRSRSRRRSRRPSPSA
CCHHHHHCCCCCCCC		31.2428889911
216PhosphorylationRRRSRRPSPSAEHNS
HHHCCCCCCCCCCCC		30.7228889911
218PhosphorylationRSRRPSPSAEHNSAE
HCCCCCCCCCCCCCC		36.9828889911
220PhosphorylationRRPSPSAEHNSAEEN
CCCCCCCCCCCCCCC		29.6719547744
222PhosphorylationPSPSAEHNSAEENDP
CCCCCCCCCCCCCCH		51.1019547744
223PhosphorylationSPSAEHNSAEENDPE
CCCCCCCCCCCCCHH		26.0028889911
227PhosphorylationEHNSAEENDPELQRV
CCCCCCCCCHHHHHH		38.6819547744
255PhosphorylationRRNMANDSEAELQKA
HHHHCCHHHHHHHHH		3.3228889911
259PhosphorylationANDSEAELQKAIQLS
CCHHHHHHHHHHHHC		38.2122817900
342PhosphorylationGFVQPQHTGFVQPQA
CCCCCCCCCCCCCCC		29.6728889911
346PhosphorylationPQHTGFVQPQATGFM
CCCCCCCCCCCCCCC		27.3722817900
350PhosphorylationGFVQPQATGFMQPQR
CCCCCCCCCCCCCCC		23.3329996109
358PhosphorylationGFMQPQRTGFVQPQA
CCCCCCCCCCCCCCC		28.8115659877
362PhosphorylationPQRTGFVQPQATGFV
CCCCCCCCCCCCCCC		29.7122817900
366PhosphorylationGFVQPQATGFVQPQA
CCCCCCCCCCCCCCC		23.3329996109
374PhosphorylationGFVQPQATGFVQPQA
CCCCCCCCCCCCCCC		23.3329996109
382PhosphorylationGFVQPQATGFMQPQR
CCCCCCCCCCCCCCC		23.3329996109
390PhosphorylationGFMQPQRTGFVQPQA
CCCCCCCCCCCCCCC		28.8115659877
398PhosphorylationGFVQPQATGFMQPQR
CCCCCCCCCCCCCCC		23.3325720772
406PhosphorylationGFMQPQRTGFVQPQA
CCCCCCCCCCCCCCC		28.8115659877
410PhosphorylationPQRTGFVQPQATGFM
CCCCCCCCCCCCCCC		29.7118257517
414PhosphorylationGFVQPQATGFMQPQR
CCCCCCCCCCCCCCC		23.3325720772
422PhosphorylationGFMQPQRTGFVQPQA
CCCCCCCCCCCCCCC		28.8115659877
426PhosphorylationPQRTGFVQPQATGFI
CCCCCCCCCCCCCCC		29.7118257517
430PhosphorylationGFVQPQATGFIQPQR
CCCCCCCCCCCCCCC		23.3329996109
438PhosphorylationGFIQPQRTGFVQPQQ
CCCCCCCCCCCCCCC		26.3029996109
454PhosphorylationGFFNPQPTGYMQPQR
CCCCCCCCCCCCCCC		31.8429996109
456PhosphorylationFNPQPTGYMQPQRTG
CCCCCCCCCCCCCCC		49.6529996109
462PhosphorylationGYMQPQRTGMMQPQR
CCCCCCCCCCCCCCC		23.6129996109
470PhosphorylationGMMQPQRTGFSQPFE
CCCCCCCCCCCCCCC		23.2929996109
473PhosphorylationQPQRTGFSQPFESNN
CCCCCCCCCCCCCCC		43.4229996109
490PhosphorylationPVMQPQRTGFGQTPN
CCCCCCCCCCCCCCC		31.0725720772
495PhosphorylationQRTGFGQTPNAPMMA
CCCCCCCCCCCCCCC		27.2029996109
506PhosphorylationPMMAPNHTGYVHPQP
CCCCCCCCCCCCCCC		8.7625720772
508PhosphorylationMAPNHTGYVHPQPTG
CCCCCCCCCCCCCCC		35.5029996109
514PhosphorylationGYVHPQPTGLQRQTT
CCCCCCCCCCCCCCC		13.5429996109
520PhosphorylationPTGLQRQTTGYTGNN
CCCCCCCCCCCCCCC		4.1129996109
521PhosphorylationTGLQRQTTGYTGNNN
CCCCCCCCCCCCCCC		36.4629996109
530PhosphorylationYTGNNNPYSRPLQSQ
CCCCCCCCCCCCHHH		36.9929996109
531PhosphorylationTGNNNPYSRPLQSQS
CCCCCCCCCCCHHHH		52.8027738172
536PhosphorylationPYSRPLQSQSTGILQ
CCCCCCHHHHHCHHH		30.0625720772
538PhosphorylationSRPLQSQSTGILQQQ
CCCCHHHHHCHHHHH		8.1129996109
539PhosphorylationRPLQSQSTGILQQQQ
CCCHHHHHCHHHHHH		41.9525720772
556PhosphorylationSAPRLEPTKTGSNNP
HCCCCCCCCCCCCCC		51.9429996109
558PhosphorylationPRLEPTKTGSNNPFA
CCCCCCCCCCCCCCH		52.8024763107
560PhosphorylationLEPTKTGSNNPFAQF
CCCCCCCCCCCCHHH		31.6821712547
572PhosphorylationAQFSNLPSQSTAPAT
HHHCCCCCCCCCCCC		25.9421712547
575PhosphorylationSNLPSQSTAPATKPM
CCCCCCCCCCCCCCC		34.2724763107
587PhosphorylationKPMKPVRTGDDRFSN
CCCCCCCCCCCCHHH		49.2221712547
593PhosphorylationRTGDDRFSNIAQAIS
CCCCCCHHHHHHHHH		43.2125720772
600PhosphorylationSNIAQAISTGNPMGT
HHHHHHHHCCCCCCC		9.3029996109
601PhosphorylationNIAQAISTGNPMGTD
HHHHHHHCCCCCCCC		35.1225720772
609PhosphorylationGNPMGTDSFGNIGLT
CCCCCCCCCCCCCCE		11.9321712547
616PhosphorylationSFGNIGLTRVPTQHT
CCCCCCCEECCCCCC		24.1221712547
623PhosphorylationTRVPTQHTGSKFTNS
EECCCCCCCCCCCCC		24.0527738172
625PhosphorylationVPTQHTGSKFTNSAG
CCCCCCCCCCCCCCC		26.5227738172
630PhosphorylationTGSKFTNSAGQTIQA
CCCCCCCCCCCEEEE		58.5127738172
634PhosphorylationFTNSAGQTIQAQATG
CCCCCCCEEEEECCC		30.6229996109
640PhosphorylationQTIQAQATGNTHNPF
CEEEEECCCCCCCCC		30.7021712547
643PhosphorylationQAQATGNTHNPFQSQ
EEECCCCCCCCCHHH		22.0824763107
649PhosphorylationNTHNPFQSQQATGYY
CCCCCCHHHHHHCCC		36.7221712547
653PhosphorylationPFQSQQATGYYKQPM
CCHHHHHHCCCCCHH		25.3321712547
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ENT1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ENT1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ENT1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SLA2_SCHPOend4genetic
23727096
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ENT1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216; SER-220; SER-222;SER-227; SER-259 AND THR-410, AND MASS SPECTROMETRY.

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