PFKA_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PFKA_SCHPO
• UniProt AC: O42938
• Protein Name: ATP-dependent 6-phosphofructokinase {ECO:0000255|HAMAP-Rule:MF_03184}
• Gene Name: pfk1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 942
• Subcellular Localization: Cytoplasm .
• Protein Description: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. May also have a role in cell cycle regulation..
• Protein Sequence: MSGETVHGISCYSVVANTEDTYNQTLDFYQKLGFKKVASFGTSDSDNARVCNESLREDWMHVAGNNSAESVTIKFRLVPGELSLSPAAEDSEWRGQKSSLVFYYPNLLDLLKQLSADAIKYQAFPNEKKPDEVYVEDPLGNLIGFSDRYNPFAHANLKKSEESGAASNLESGLATPVVETLKKATTSDKPAGVKKKIAVMTSGGDSPGMNAVVRAVARIAIHRGCDAFAIYEGYEGLVQGGDMIKQLQWGDVRGWLAEGGTLIGTARCMAFRERPGRLRAAKNLISAGIDSIIVCGGDGSLTGADIFRSDWPGLVKELEDTKAITPEQAKLYRHLTIVGLVGSIDNDMSSTDVTIGAFSSLHRICEAVDSISSTAISHSRAFIVEVMGRHCGWLAVLAALATGADFVFIPERPAEVGKWQDELCNSLSSVRKLGKRKSIVIVAEGAIDSELNHISPEDIKNLLVERLHLDTRVTTLGHVQRGGIPCAYDRMLATLQGVDAVDAVLASTPDTPSPMIAINGNKINRKPLMEAVKLTHEVADAIEKKQFAHAMELRDPEFADYLHTWEGTTFIEDESHFVPKDERMRVAIIHVGAPAGGMNSATRAAVRYCLNRGHTPLAIDNGFSGFLRHDSIHELSWIDVDEWCIRGGSEIGTNRDTPDLDMGFTAFKFQQHKIDALIIIGGFEAFTALSQLESARVNYPSFRIPMAIIPATISNNVPGTEFSLGCDTCLNAVMEYCDTIKQSASASRRRVFVCEVQGGRSGYIATVGGLITGASAIYTPEDGISLDMLRKDIDHLKATFALEAGRNRAGQLILRNECASKVYTTEVIGNIISEEAHKRFSARTAVPGHVQQGGNPTPMDRARAARLAMRAIRFFETCRANDLGNDPSSAVVIGIRGTGVSFSSVADVENNETEIEMRRPKNAWWRDMHNLVNILAGKTFAD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	LGFKKVASFGTSDSD HCCCEEECCCCCCCC		25720772
43	Phosphorylation	KVASFGTSDSDNARV EEECCCCCCCCCCEE		28889911
45	Phosphorylation	ASFGTSDSDNARVCN ECCCCCCCCCCEECC		28889911
83	Phosphorylation	RLVPGELSLSPAAED EECCCEEECCCCCCC		29996109
85	Phosphorylation	VPGELSLSPAAEDSE CCCEEECCCCCCCCC		28889911
160	Phosphorylation	AHANLKKSEESGAAS CCCCCCCHHHCCCCC		28889911
163	Phosphorylation	NLKKSEESGAASNLE CCCCHHHCCCCCCHH		28889911
167	Phosphorylation	SEESGAASNLESGLA HHHCCCCCCHHHCCC		28889911
171	Phosphorylation	GAASNLESGLATPVV CCCCCHHHCCCCHHH		28889911
175	Phosphorylation	NLESGLATPVVETLK CHHHCCCCHHHHHHH		28889911
180	Phosphorylation	LATPVVETLKKATTS CCCHHHHHHHHHCCC		28889911
185	Phosphorylation	VETLKKATTSDKPAG HHHHHHHCCCCCCCC		24763107
186	Phosphorylation	ETLKKATTSDKPAGV HHHHHHCCCCCCCCC		21712547
187	Phosphorylation	TLKKATTSDKPAGVK HHHHHCCCCCCCCCC		21712547
508	Phosphorylation	VDAVLASTPDTPSPM HHHHHHCCCCCCCCE		25720772
600	Phosphorylation	APAGGMNSATRAAVR CCCCCCCHHHHHHHH		28889911
602	Phosphorylation	AGGMNSATRAAVRYC CCCCCHHHHHHHHHH		28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PFKA_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PFKA_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PFKA_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of PFKA_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.