dbPTM

BBP_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BBP_SCHPO
UniProt AC	O74555
Protein Name	Branchpoint-bridging protein
Gene Name	bpb1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	587
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	Necessary for the splicing of pre-mRNA. The BPB1(SF1)-u2af59-u2af23 complex has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns..
Protein Sequence	MLNSRSVGSTGSNNTPLGRRRFDEKPDSLPPLPDANGMSNGYRDSYKSNSRMDHRPDGYHDGRGRRAYRKHYWGHPTPIEEMLPSQMELETAVKSCMTMEQLELYSLNVRLEEITQKLRTGDVVPHHRERSPSPPPQYDNHGRRLNTREIRYKKKLEDERHRIIERAMKMVPGFRAPSDYRRPAKTQEKVYVPVKDYPEINFIGLLIGPRGHTLKDMEAKSGAKIAIRGKGSVKEGKGRSDPSVRGNMEEDLHCLVTADSEDKINHAIKLIDNVIQTAASVPEGQNDLKRNQLRQLATLNGTLRDDENQVCQNCGNVGHRRFDCPERINHTMNIVCRHCGSIGHIARDCPVRDQQPPMADSTADREYQSLMQELGGGSAISNGNGEPQKSIEFSESGAASPQAGHPPPWAAASTSVSSSTSSPAPWAKPASSAAPSNPAPWQQPAAPQSAPALSMNPSSLPPWQQPTQQSAVQPSNLVPSQNAPFIPGTSAPLPPTTFAPPGVPLPPIPGAPGMPNLNMSQPPMVPPGMALPPGMPAPFPGYPAVPAMPGIPGATAPPGAPGSYNTSESSNLNAPPGVSMPNGYSNR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MLNSRSVGSTGSN --CCCCCCCCCCCCC	30.56	29996109
9	Phosphorylation	LNSRSVGSTGSNNTP CCCCCCCCCCCCCCC	27.69	29996109
10	Phosphorylation	NSRSVGSTGSNNTPL CCCCCCCCCCCCCCC	38.41	29996109
12	Phosphorylation	RSVGSTGSNNTPLGR CCCCCCCCCCCCCCC	27.31	29996109
15	Phosphorylation	GSTGSNNTPLGRRRF CCCCCCCCCCCCCCC	24.92	29996109
131	Phosphorylation	VPHHRERSPSPPPQY CCCCCCCCCCCCCCC	25.61	28889911
133	Phosphorylation	HHRERSPSPPPQYDN CCCCCCCCCCCCCCC	51.81	28889911
138	Phosphorylation	SPSPPPQYDNHGRRL CCCCCCCCCCCCCCC	25.20	29996109
390	Phosphorylation	GNGEPQKSIEFSESG CCCCCCCEEEECCCC	23.31	21712547
394	Phosphorylation	PQKSIEFSESGAASP CCCEEEECCCCCCCC	20.33	27738172
396	Phosphorylation	KSIEFSESGAASPQA CEEEECCCCCCCCCC	32.31	27738172
400	Phosphorylation	FSESGAASPQAGHPP ECCCCCCCCCCCCCC	19.60	21712547
419	Phosphorylation	ASTSVSSSTSSPAPW HCCCCCCCCCCCCCC	25.46	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of BBP_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BBP_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BBP_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
U2AF2_SCHPO	prp2	physical	10923022
YC93_SCHPO	SPCC584.03c	genetic	22681890
GET1_SCHPO	get1	genetic	22681890
SRP2_SCHPO	srp2	genetic	26302002

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BBP_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131 AND SER-133, ANDMASS SPECTROMETRY.	18257517 [Abstract]