UniProt ID | IF4G_SCHPO | |
---|---|---|
UniProt AC | Q10475 | |
Protein Name | Eukaryotic translation initiation factor 4 gamma | |
Gene Name | tif471 | |
Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
Sequence Length | 1403 | |
Subcellular Localization | Cytoplasm, perinuclear region . Localized to the perinuclear region, the growing tips and septum. | |
Protein Description | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.. | |
Protein Sequence | MSSKPPSNTPKFSYARALASSQSNKSNSTKASENNTATAEKQAVKPSGVEPTNTSRANAQKKTESTGKITSEADTEKYNSSKSPVNKEGSVEKKSSEKSSTNNKPWRGDNTSKPSANSSAERTSSQHQKPETSSQIGKDNAAPVENVNEKSTSQETAPPVSTVPIQFGSITRNAAIPSKPKVSGNMQNKSGVSSYSSKSQSVNSSVTSNPPHTEEPVAAKPEASSTATKGPRPTTSASNTNTSPANGAPTNKPSTDINTTDPATQTTQVSASNSPALSGSSTPSNTSSRSNRQNHGNFSEKRHYDRYGNSHPSYNKYSHYQHGFNYNNSGNNRNESGHPRFRNSRRNYNNQGAYPTYMSNGRSANQSPRNNPQNVNNGSTPIQIPVSLQTPYGQVYGQPQYIVDPNMVQYGPILQPGYVPQYYPVYHQTPYTQNFPNMSRSGSQVSDQVVESPNSSTLSPRNGFAPIVKQQKKSSALKIVNPVTHTEVVVPQKNASSPNPSETNSRAETPTAAPPQISEEEASQRKDAIKLAIQQRIQEKAEAEAKRKAEEKARLEAEENAKREAEEQAKREAEEKAKREAEEKAKREAEEKAKREAEENAKREAEEKAKREAEEKAKREAEEKAKREAEEKAKREAEEKAKREAEEKAKREAEEKAKREAEENAKREAEEKAKREAEENAKREAEEKVKRETEENAKRKAEEEGKREADKNPEIKSSAPLASSEANVDTSKQTNATEPEVVDKTKVEKLKASEGKSTSSLSSPSHSTSSKRDLLSGLESLSLKTNPKSEQCLESLLNSQFITDFSALVYPSTIKPPSTEEALKAGKYEYDVPFLLQFQSVYTDKPMKGWDERMKETVASAFSDKSSRGMYSSSRQSSRSGSNTHSHAGPGFGGPSERKGISRLGIDRGFSSSGAGFGSGSNYKSAPSRGVSHHGHGGMSGSHRGSQRGSRRGGGERDKPDPSSLTIPVDQVAPLQLSANRWQPKKLTEKPAETKGEDEEALLPPEVVQRKVKGSLNKMTLEKFDKISDQILEIAMQSRKENDGRTLKQVIQLTFEKATDEPNFSNMYARFARKMMDSIDDSIRDEGVLDKNNQPVRGGLLFRKYLLSRCQEDFERGWKANLPSGKAGEAEIMSDEYYVAAAIKRRGLGLVRFIGELFKLSMLSEKIMHECIKRLLGNVTDPEEEEIESLCRLLMTVGVNIDATEKGHAAMDVYVLRMETITKIPNLPSRIKFMLMDVMDSRKNGWAVKNEVEKGPKTIAEIHEEAERKKALAESQRPSSGRMHGRDMNRGDSRMGGRGSNPPFSSSDWSNNKDGYARLGQGIRGLKSGTQGSHGPTSLSSMLKGGSVSRTPSRQNSALRREQSVRAPPSNVAVTSANSFELLEEHDHDNDGGQKDSNSKTSS | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
9 | Phosphorylation | SSKPPSNTPKFSYAR CCCCCCCCCCHHHHH | 31.99 | 29996109 | |
20 | Phosphorylation | SYARALASSQSNKSN HHHHHHHHHHCCCCC | 29.75 | 24763107 | |
71 | Phosphorylation | ESTGKITSEADTEKY CCCCCCCCHHHHCHH | 33.97 | 25720772 | |
80 | Phosphorylation | ADTEKYNSSKSPVNK HHHCHHCCCCCCCCC | 35.73 | 21712547 | |
81 | Phosphorylation | DTEKYNSSKSPVNKE HHCHHCCCCCCCCCC | 33.25 | 28889911 | |
83 | Phosphorylation | EKYNSSKSPVNKEGS CHHCCCCCCCCCCCC | 35.71 | 28889911 | |
123 | Phosphorylation | ANSSAERTSSQHQKP CCCCCCCCCCCCCCC | 25.00 | 27738172 | |
125 | Phosphorylation | SSAERTSSQHQKPET CCCCCCCCCCCCCCC | 30.94 | 29996109 | |
132 | Phosphorylation | SQHQKPETSSQIGKD CCCCCCCCHHHCCCC | 42.05 | 24763107 | |
133 | Phosphorylation | QHQKPETSSQIGKDN CCCCCCCHHHCCCCC | 20.70 | 25720772 | |
134 | Phosphorylation | HQKPETSSQIGKDNA CCCCCCHHHCCCCCC | 32.98 | 25720772 | |
169 | Phosphorylation | TVPIQFGSITRNAAI CCCEECCCEECCCCC | 23.29 | 27738172 | |
199 | Phosphorylation | VSSYSSKSQSVNSSV CCCCCCCCCCCCCCC | 29.63 | 27738172 | |
205 | Phosphorylation | KSQSVNSSVTSNPPH CCCCCCCCCCCCCCC | 24.98 | 27738172 | |
208 | Phosphorylation | SVNSSVTSNPPHTEE CCCCCCCCCCCCCCC | 45.22 | 27738172 | |
243 | Phosphorylation | SASNTNTSPANGAPT CCCCCCCCCCCCCCC | 24.88 | 21712547 | |
250 | Phosphorylation | SPANGAPTNKPSTDI CCCCCCCCCCCCCCC | 56.17 | 21712547 | |
270 | Phosphorylation | ATQTTQVSASNSPAL CCCCEEEECCCCCCC | 19.03 | 27738172 | |
272 | Phosphorylation | QTTQVSASNSPALSG CCEEEECCCCCCCCC | 30.27 | 27738172 | |
363 | Phosphorylation | TYMSNGRSANQSPRN CCCCCCCCCCCCCCC | 32.73 | 25720772 | |
367 | Phosphorylation | NGRSANQSPRNNPQN CCCCCCCCCCCCCCC | 26.15 | 25720772 | |
441 | Phosphorylation | NFPNMSRSGSQVSDQ CCCCCCCCCCCCCCC | 35.17 | 29996109 | |
443 | Phosphorylation | PNMSRSGSQVSDQVV CCCCCCCCCCCCCEE | 28.76 | 29996109 | |
446 | Phosphorylation | SRSGSQVSDQVVESP CCCCCCCCCCEECCC | 18.06 | 29996109 | |
452 | Phosphorylation | VSDQVVESPNSSTLS CCCCEECCCCCCCCC | 20.12 | 28889911 | |
455 | Phosphorylation | QVVESPNSSTLSPRN CEECCCCCCCCCCCC | 28.25 | 28889911 | |
456 | Phosphorylation | VVESPNSSTLSPRNG EECCCCCCCCCCCCC | 39.75 | 28889911 | |
457 | Phosphorylation | VESPNSSTLSPRNGF ECCCCCCCCCCCCCC | 30.95 | 25720772 | |
459 | Phosphorylation | SPNSSTLSPRNGFAP CCCCCCCCCCCCCHH | 23.15 | 28889911 | |
496 | Phosphorylation | VVPQKNASSPNPSET EECCCCCCCCCCHHC | 56.58 | 24763107 | |
497 | Phosphorylation | VPQKNASSPNPSETN ECCCCCCCCCCHHCC | 26.70 | 29996109 | |
501 | Phosphorylation | NASSPNPSETNSRAE CCCCCCCHHCCCCCC | 64.79 | 24763107 | |
503 | Phosphorylation | SSPNPSETNSRAETP CCCCCHHCCCCCCCC | 42.71 | 21712547 | |
505 | Phosphorylation | PNPSETNSRAETPTA CCCHHCCCCCCCCCC | 40.04 | 28889911 | |
509 | Phosphorylation | ETNSRAETPTAAPPQ HCCCCCCCCCCCCCC | 25.59 | 28889911 | |
511 | Phosphorylation | NSRAETPTAAPPQIS CCCCCCCCCCCCCCC | 42.76 | 29996109 | |
518 | Phosphorylation | TAAPPQISEEEASQR CCCCCCCCHHHHHHH | 33.44 | 28889911 | |
723 | Phosphorylation | KSSAPLASSEANVDT HCCCCCCCCCCCCCC | 36.07 | 29996109 | |
724 | Phosphorylation | SSAPLASSEANVDTS CCCCCCCCCCCCCCC | 34.81 | 25720772 | |
757 | Phosphorylation | LKASEGKSTSSLSSP HHCCCCCCCCCCCCC | 44.36 | 21712547 | |
758 | Phosphorylation | KASEGKSTSSLSSPS HCCCCCCCCCCCCCC | 26.31 | 29996109 | |
759 | Phosphorylation | ASEGKSTSSLSSPSH CCCCCCCCCCCCCCC | 36.05 | 21712547 | |
760 | Phosphorylation | SEGKSTSSLSSPSHS CCCCCCCCCCCCCCC | 32.15 | 29996109 | |
762 | Phosphorylation | GKSTSSLSSPSHSTS CCCCCCCCCCCCCCC | 41.99 | 21712547 | |
763 | Phosphorylation | KSTSSLSSPSHSTSS CCCCCCCCCCCCCCC | 35.40 | 24763107 | |
765 | Phosphorylation | TSSLSSPSHSTSSKR CCCCCCCCCCCCCHH | 31.83 | 24763107 | |
767 | Phosphorylation | SLSSPSHSTSSKRDL CCCCCCCCCCCHHHH | 34.03 | 24763107 | |
768 | Phosphorylation | LSSPSHSTSSKRDLL CCCCCCCCCCHHHHH | 31.43 | 24763107 | |
769 | Phosphorylation | SSPSHSTSSKRDLLS CCCCCCCCCHHHHHH | 36.56 | 24763107 | |
770 | Phosphorylation | SPSHSTSSKRDLLSG CCCCCCCCHHHHHHH | 31.62 | 24763107 | |
776 | Phosphorylation | SSKRDLLSGLESLSL CCHHHHHHHHHHHCC | 48.94 | 25720772 | |
780 | Phosphorylation | DLLSGLESLSLKTNP HHHHHHHHHCCCCCC | 28.44 | 25720772 | |
782 | Phosphorylation | LSGLESLSLKTNPKS HHHHHHHCCCCCCCH | 36.78 | 25720772 | |
866 | Phosphorylation | ASAFSDKSSRGMYSS HHHHCCCCCCCCCCC | 30.20 | 28889911 | |
867 | Phosphorylation | SAFSDKSSRGMYSSS HHHCCCCCCCCCCCC | 38.30 | 29996109 | |
874 | Phosphorylation | SRGMYSSSRQSSRSG CCCCCCCCCCCCCCC | 28.53 | 29996109 | |
877 | Phosphorylation | MYSSSRQSSRSGSNT CCCCCCCCCCCCCCC | 26.97 | 29996109 | |
878 | Phosphorylation | YSSSRQSSRSGSNTH CCCCCCCCCCCCCCC | 23.33 | 27738172 | |
880 | Phosphorylation | SSRQSSRSGSNTHSH CCCCCCCCCCCCCCC | 48.82 | 28889911 | |
882 | Phosphorylation | RQSSRSGSNTHSHAG CCCCCCCCCCCCCCC | 39.54 | 28889911 | |
884 | Phosphorylation | SSRSGSNTHSHAGPG CCCCCCCCCCCCCCC | 26.84 | 28889911 | |
886 | Phosphorylation | RSGSNTHSHAGPGFG CCCCCCCCCCCCCCC | 17.00 | 28889911 | |
896 | Phosphorylation | GPGFGGPSERKGISR CCCCCCCCCCCCHHH | 53.99 | 25720772 | |
902 | Phosphorylation | PSERKGISRLGIDRG CCCCCCHHHCCCCCC | 30.07 | 24763107 | |
911 | Phosphorylation | LGIDRGFSSSGAGFG CCCCCCCCCCCCCCC | 26.81 | 28889911 | |
912 | Phosphorylation | GIDRGFSSSGAGFGS CCCCCCCCCCCCCCC | 30.45 | 24763107 | |
913 | Phosphorylation | IDRGFSSSGAGFGSG CCCCCCCCCCCCCCC | 31.31 | 28889911 | |
919 | Phosphorylation | SSGAGFGSGSNYKSA CCCCCCCCCCCCCCC | 36.47 | 28889911 | |
921 | Phosphorylation | GAGFGSGSNYKSAPS CCCCCCCCCCCCCCC | 38.39 | 28889911 | |
923 | Phosphorylation | GFGSGSNYKSAPSRG CCCCCCCCCCCCCCC | 14.17 | 28889911 | |
932 | Phosphorylation | SAPSRGVSHHGHGGM CCCCCCCCCCCCCCC | 16.76 | 29996109 | |
942 | Phosphorylation | GHGGMSGSHRGSQRG CCCCCCCCCCCCCCC | 11.60 | 29996109 | |
963 | Phosphorylation | ERDKPDPSSLTIPVD CCCCCCCCCCEEEHH | 45.41 | 25720772 | |
1279 | Phosphorylation | LAESQRPSSGRMHGR HHHHCCCCCCCCCCC | 47.84 | 29996109 | |
1280 | Phosphorylation | AESQRPSSGRMHGRD HHHCCCCCCCCCCCC | 32.85 | 25720772 | |
1300 | Phosphorylation | SRMGGRGSNPPFSSS CCCCCCCCCCCCCCC | 44.81 | 28889911 | |
1328 | Phosphorylation | QGIRGLKSGTQGSHG HHHCCCCCCCCCCCC | 52.71 | 21712547 | |
1333 | Phosphorylation | LKSGTQGSHGPTSLS CCCCCCCCCCCCCHH | 18.56 | 28889911 | |
1337 | Phosphorylation | TQGSHGPTSLSSMLK CCCCCCCCCHHHHHC | 47.06 | 28889911 | |
1340 | Phosphorylation | SHGPTSLSSMLKGGS CCCCCCHHHHHCCCC | 17.30 | 27738172 | |
1347 | Phosphorylation | SSMLKGGSVSRTPSR HHHHCCCCCCCCCCH | 26.11 | 29996109 | |
1351 | Phosphorylation | KGGSVSRTPSRQNSA CCCCCCCCCCHHCHH | 20.36 | 29996109 | |
1353 | Phosphorylation | GSVSRTPSRQNSALR CCCCCCCCHHCHHHH | 45.98 | 29996109 | |
1357 | Phosphorylation | RTPSRQNSALRREQS CCCCHHCHHHHHHHH | 21.97 | 29996109 | |
1376 | Phosphorylation | PSNVAVTSANSFELL CCCEEEEECCHHHHH | 20.89 | 29996109 | |
1379 | Phosphorylation | VAVTSANSFELLEEH EEEEECCHHHHHHHC | 21.58 | 29996109 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IF4G_SCHPO !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IF4G_SCHPO !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IF4G_SCHPO !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
ULP2_SCHPO | ulp2 | physical | 24818994 |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-452; SER-455;SER-456; SER-459; SER-866; SER-882; THR-884; SER-886; SER-911;SER-919; SER-921; TYR-923 AND SER-1333, AND MASS SPECTROMETRY. |