IF4G_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IF4G_SCHPO
• UniProt AC: Q10475
• Protein Name: Eukaryotic translation initiation factor 4 gamma
• Gene Name: tif471
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1403
• Subcellular Localization: Cytoplasm, perinuclear region . Localized to the perinuclear region, the growing tips and septum.
• Protein Description: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome..
• Protein Sequence: MSSKPPSNTPKFSYARALASSQSNKSNSTKASENNTATAEKQAVKPSGVEPTNTSRANAQKKTESTGKITSEADTEKYNSSKSPVNKEGSVEKKSSEKSSTNNKPWRGDNTSKPSANSSAERTSSQHQKPETSSQIGKDNAAPVENVNEKSTSQETAPPVSTVPIQFGSITRNAAIPSKPKVSGNMQNKSGVSSYSSKSQSVNSSVTSNPPHTEEPVAAKPEASSTATKGPRPTTSASNTNTSPANGAPTNKPSTDINTTDPATQTTQVSASNSPALSGSSTPSNTSSRSNRQNHGNFSEKRHYDRYGNSHPSYNKYSHYQHGFNYNNSGNNRNESGHPRFRNSRRNYNNQGAYPTYMSNGRSANQSPRNNPQNVNNGSTPIQIPVSLQTPYGQVYGQPQYIVDPNMVQYGPILQPGYVPQYYPVYHQTPYTQNFPNMSRSGSQVSDQVVESPNSSTLSPRNGFAPIVKQQKKSSALKIVNPVTHTEVVVPQKNASSPNPSETNSRAETPTAAPPQISEEEASQRKDAIKLAIQQRIQEKAEAEAKRKAEEKARLEAEENAKREAEEQAKREAEEKAKREAEEKAKREAEEKAKREAEENAKREAEEKAKREAEEKAKREAEEKAKREAEEKAKREAEEKAKREAEEKAKREAEEKAKREAEENAKREAEEKAKREAEENAKREAEEKVKRETEENAKRKAEEEGKREADKNPEIKSSAPLASSEANVDTSKQTNATEPEVVDKTKVEKLKASEGKSTSSLSSPSHSTSSKRDLLSGLESLSLKTNPKSEQCLESLLNSQFITDFSALVYPSTIKPPSTEEALKAGKYEYDVPFLLQFQSVYTDKPMKGWDERMKETVASAFSDKSSRGMYSSSRQSSRSGSNTHSHAGPGFGGPSERKGISRLGIDRGFSSSGAGFGSGSNYKSAPSRGVSHHGHGGMSGSHRGSQRGSRRGGGERDKPDPSSLTIPVDQVAPLQLSANRWQPKKLTEKPAETKGEDEEALLPPEVVQRKVKGSLNKMTLEKFDKISDQILEIAMQSRKENDGRTLKQVIQLTFEKATDEPNFSNMYARFARKMMDSIDDSIRDEGVLDKNNQPVRGGLLFRKYLLSRCQEDFERGWKANLPSGKAGEAEIMSDEYYVAAAIKRRGLGLVRFIGELFKLSMLSEKIMHECIKRLLGNVTDPEEEEIESLCRLLMTVGVNIDATEKGHAAMDVYVLRMETITKIPNLPSRIKFMLMDVMDSRKNGWAVKNEVEKGPKTIAEIHEEAERKKALAESQRPSSGRMHGRDMNRGDSRMGGRGSNPPFSSSDWSNNKDGYARLGQGIRGLKSGTQGSHGPTSLSSMLKGGSVSRTPSRQNSALRREQSVRAPPSNVAVTSANSFELLEEHDHDNDGGQKDSNSKTSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	SSKPPSNTPKFSYAR CCCCCCCCCCHHHHH	31.99	29996109
20	Phosphorylation	SYARALASSQSNKSN HHHHHHHHHHCCCCC	29.75	24763107
71	Phosphorylation	ESTGKITSEADTEKY CCCCCCCCHHHHCHH	33.97	25720772
80	Phosphorylation	ADTEKYNSSKSPVNK HHHCHHCCCCCCCCC	35.73	21712547
81	Phosphorylation	DTEKYNSSKSPVNKE HHCHHCCCCCCCCCC	33.25	28889911
83	Phosphorylation	EKYNSSKSPVNKEGS CHHCCCCCCCCCCCC	35.71	28889911
123	Phosphorylation	ANSSAERTSSQHQKP CCCCCCCCCCCCCCC	25.00	27738172
125	Phosphorylation	SSAERTSSQHQKPET CCCCCCCCCCCCCCC	30.94	29996109
132	Phosphorylation	SQHQKPETSSQIGKD CCCCCCCCHHHCCCC	42.05	24763107
133	Phosphorylation	QHQKPETSSQIGKDN CCCCCCCHHHCCCCC	20.70	25720772
134	Phosphorylation	HQKPETSSQIGKDNA CCCCCCHHHCCCCCC	32.98	25720772
169	Phosphorylation	TVPIQFGSITRNAAI CCCEECCCEECCCCC	23.29	27738172
199	Phosphorylation	VSSYSSKSQSVNSSV CCCCCCCCCCCCCCC	29.63	27738172
205	Phosphorylation	KSQSVNSSVTSNPPH CCCCCCCCCCCCCCC	24.98	27738172
208	Phosphorylation	SVNSSVTSNPPHTEE CCCCCCCCCCCCCCC	45.22	27738172
243	Phosphorylation	SASNTNTSPANGAPT CCCCCCCCCCCCCCC	24.88	21712547
250	Phosphorylation	SPANGAPTNKPSTDI CCCCCCCCCCCCCCC	56.17	21712547
270	Phosphorylation	ATQTTQVSASNSPAL CCCCEEEECCCCCCC	19.03	27738172
272	Phosphorylation	QTTQVSASNSPALSG CCEEEECCCCCCCCC	30.27	27738172
363	Phosphorylation	TYMSNGRSANQSPRN CCCCCCCCCCCCCCC	32.73	25720772
367	Phosphorylation	NGRSANQSPRNNPQN CCCCCCCCCCCCCCC	26.15	25720772
441	Phosphorylation	NFPNMSRSGSQVSDQ CCCCCCCCCCCCCCC	35.17	29996109
443	Phosphorylation	PNMSRSGSQVSDQVV CCCCCCCCCCCCCEE	28.76	29996109
446	Phosphorylation	SRSGSQVSDQVVESP CCCCCCCCCCEECCC	18.06	29996109
452	Phosphorylation	VSDQVVESPNSSTLS CCCCEECCCCCCCCC	20.12	28889911
455	Phosphorylation	QVVESPNSSTLSPRN CEECCCCCCCCCCCC	28.25	28889911
456	Phosphorylation	VVESPNSSTLSPRNG EECCCCCCCCCCCCC	39.75	28889911
457	Phosphorylation	VESPNSSTLSPRNGF ECCCCCCCCCCCCCC	30.95	25720772
459	Phosphorylation	SPNSSTLSPRNGFAP CCCCCCCCCCCCCHH	23.15	28889911
496	Phosphorylation	VVPQKNASSPNPSET EECCCCCCCCCCHHC	56.58	24763107
497	Phosphorylation	VPQKNASSPNPSETN ECCCCCCCCCCHHCC	26.70	29996109
501	Phosphorylation	NASSPNPSETNSRAE CCCCCCCHHCCCCCC	64.79	24763107
503	Phosphorylation	SSPNPSETNSRAETP CCCCCHHCCCCCCCC	42.71	21712547
505	Phosphorylation	PNPSETNSRAETPTA CCCHHCCCCCCCCCC	40.04	28889911
509	Phosphorylation	ETNSRAETPTAAPPQ HCCCCCCCCCCCCCC	25.59	28889911
511	Phosphorylation	NSRAETPTAAPPQIS CCCCCCCCCCCCCCC	42.76	29996109
518	Phosphorylation	TAAPPQISEEEASQR CCCCCCCCHHHHHHH	33.44	28889911
723	Phosphorylation	KSSAPLASSEANVDT HCCCCCCCCCCCCCC	36.07	29996109
724	Phosphorylation	SSAPLASSEANVDTS CCCCCCCCCCCCCCC	34.81	25720772
757	Phosphorylation	LKASEGKSTSSLSSP HHCCCCCCCCCCCCC	44.36	21712547
758	Phosphorylation	KASEGKSTSSLSSPS HCCCCCCCCCCCCCC	26.31	29996109
759	Phosphorylation	ASEGKSTSSLSSPSH CCCCCCCCCCCCCCC	36.05	21712547
760	Phosphorylation	SEGKSTSSLSSPSHS CCCCCCCCCCCCCCC	32.15	29996109
762	Phosphorylation	GKSTSSLSSPSHSTS CCCCCCCCCCCCCCC	41.99	21712547
763	Phosphorylation	KSTSSLSSPSHSTSS CCCCCCCCCCCCCCC	35.40	24763107
765	Phosphorylation	TSSLSSPSHSTSSKR CCCCCCCCCCCCCHH	31.83	24763107
767	Phosphorylation	SLSSPSHSTSSKRDL CCCCCCCCCCCHHHH	34.03	24763107
768	Phosphorylation	LSSPSHSTSSKRDLL CCCCCCCCCCHHHHH	31.43	24763107
769	Phosphorylation	SSPSHSTSSKRDLLS CCCCCCCCCHHHHHH	36.56	24763107
770	Phosphorylation	SPSHSTSSKRDLLSG CCCCCCCCHHHHHHH	31.62	24763107
776	Phosphorylation	SSKRDLLSGLESLSL CCHHHHHHHHHHHCC	48.94	25720772
780	Phosphorylation	DLLSGLESLSLKTNP HHHHHHHHHCCCCCC	28.44	25720772
782	Phosphorylation	LSGLESLSLKTNPKS HHHHHHHCCCCCCCH	36.78	25720772
866	Phosphorylation	ASAFSDKSSRGMYSS HHHHCCCCCCCCCCC	30.20	28889911
867	Phosphorylation	SAFSDKSSRGMYSSS HHHCCCCCCCCCCCC	38.30	29996109
874	Phosphorylation	SRGMYSSSRQSSRSG CCCCCCCCCCCCCCC	28.53	29996109
877	Phosphorylation	MYSSSRQSSRSGSNT CCCCCCCCCCCCCCC	26.97	29996109
878	Phosphorylation	YSSSRQSSRSGSNTH CCCCCCCCCCCCCCC	23.33	27738172
880	Phosphorylation	SSRQSSRSGSNTHSH CCCCCCCCCCCCCCC	48.82	28889911
882	Phosphorylation	RQSSRSGSNTHSHAG CCCCCCCCCCCCCCC	39.54	28889911
884	Phosphorylation	SSRSGSNTHSHAGPG CCCCCCCCCCCCCCC	26.84	28889911
886	Phosphorylation	RSGSNTHSHAGPGFG CCCCCCCCCCCCCCC	17.00	28889911
896	Phosphorylation	GPGFGGPSERKGISR CCCCCCCCCCCCHHH	53.99	25720772
902	Phosphorylation	PSERKGISRLGIDRG CCCCCCHHHCCCCCC	30.07	24763107
911	Phosphorylation	LGIDRGFSSSGAGFG CCCCCCCCCCCCCCC	26.81	28889911
912	Phosphorylation	GIDRGFSSSGAGFGS CCCCCCCCCCCCCCC	30.45	24763107
913	Phosphorylation	IDRGFSSSGAGFGSG CCCCCCCCCCCCCCC	31.31	28889911
919	Phosphorylation	SSGAGFGSGSNYKSA CCCCCCCCCCCCCCC	36.47	28889911
921	Phosphorylation	GAGFGSGSNYKSAPS CCCCCCCCCCCCCCC	38.39	28889911
923	Phosphorylation	GFGSGSNYKSAPSRG CCCCCCCCCCCCCCC	14.17	28889911
932	Phosphorylation	SAPSRGVSHHGHGGM CCCCCCCCCCCCCCC	16.76	29996109
942	Phosphorylation	GHGGMSGSHRGSQRG CCCCCCCCCCCCCCC	11.60	29996109
963	Phosphorylation	ERDKPDPSSLTIPVD CCCCCCCCCCEEEHH	45.41	25720772
1279	Phosphorylation	LAESQRPSSGRMHGR HHHHCCCCCCCCCCC	47.84	29996109
1280	Phosphorylation	AESQRPSSGRMHGRD HHHCCCCCCCCCCCC	32.85	25720772
1300	Phosphorylation	SRMGGRGSNPPFSSS CCCCCCCCCCCCCCC	44.81	28889911
1328	Phosphorylation	QGIRGLKSGTQGSHG HHHCCCCCCCCCCCC	52.71	21712547
1333	Phosphorylation	LKSGTQGSHGPTSLS CCCCCCCCCCCCCHH	18.56	28889911
1337	Phosphorylation	TQGSHGPTSLSSMLK CCCCCCCCCHHHHHC	47.06	28889911
1340	Phosphorylation	SHGPTSLSSMLKGGS CCCCCCHHHHHCCCC	17.30	27738172
1347	Phosphorylation	SSMLKGGSVSRTPSR HHHHCCCCCCCCCCH	26.11	29996109
1351	Phosphorylation	KGGSVSRTPSRQNSA CCCCCCCCCCHHCHH	20.36	29996109
1353	Phosphorylation	GSVSRTPSRQNSALR CCCCCCCCHHCHHHH	45.98	29996109
1357	Phosphorylation	RTPSRQNSALRREQS CCCCHHCHHHHHHHH	21.97	29996109
1376	Phosphorylation	PSNVAVTSANSFELL CCCEEEEECCHHHHH	20.89	29996109
1379	Phosphorylation	VAVTSANSFELLEEH EEEEECCHHHHHHHC	21.58	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IF4G_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IF4G_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IF4G_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ULP2_SCHPO	ulp2	physical	24818994

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-452; SER-455;SER-456; SER-459; SER-866; SER-882; THR-884; SER-886; SER-911;SER-919; SER-921; TYR-923 AND SER-1333, AND MASS SPECTROMETRY.
PubMed: 18257517