IF4G_SCHPO - dbPTM
IF4G_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IF4G_SCHPO
UniProt AC Q10475
Protein Name Eukaryotic translation initiation factor 4 gamma
Gene Name tif471
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1403
Subcellular Localization Cytoplasm, perinuclear region . Localized to the perinuclear region, the growing tips and septum.
Protein Description Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome..
Protein Sequence MSSKPPSNTPKFSYARALASSQSNKSNSTKASENNTATAEKQAVKPSGVEPTNTSRANAQKKTESTGKITSEADTEKYNSSKSPVNKEGSVEKKSSEKSSTNNKPWRGDNTSKPSANSSAERTSSQHQKPETSSQIGKDNAAPVENVNEKSTSQETAPPVSTVPIQFGSITRNAAIPSKPKVSGNMQNKSGVSSYSSKSQSVNSSVTSNPPHTEEPVAAKPEASSTATKGPRPTTSASNTNTSPANGAPTNKPSTDINTTDPATQTTQVSASNSPALSGSSTPSNTSSRSNRQNHGNFSEKRHYDRYGNSHPSYNKYSHYQHGFNYNNSGNNRNESGHPRFRNSRRNYNNQGAYPTYMSNGRSANQSPRNNPQNVNNGSTPIQIPVSLQTPYGQVYGQPQYIVDPNMVQYGPILQPGYVPQYYPVYHQTPYTQNFPNMSRSGSQVSDQVVESPNSSTLSPRNGFAPIVKQQKKSSALKIVNPVTHTEVVVPQKNASSPNPSETNSRAETPTAAPPQISEEEASQRKDAIKLAIQQRIQEKAEAEAKRKAEEKARLEAEENAKREAEEQAKREAEEKAKREAEEKAKREAEEKAKREAEENAKREAEEKAKREAEEKAKREAEEKAKREAEEKAKREAEEKAKREAEEKAKREAEEKAKREAEENAKREAEEKAKREAEENAKREAEEKVKRETEENAKRKAEEEGKREADKNPEIKSSAPLASSEANVDTSKQTNATEPEVVDKTKVEKLKASEGKSTSSLSSPSHSTSSKRDLLSGLESLSLKTNPKSEQCLESLLNSQFITDFSALVYPSTIKPPSTEEALKAGKYEYDVPFLLQFQSVYTDKPMKGWDERMKETVASAFSDKSSRGMYSSSRQSSRSGSNTHSHAGPGFGGPSERKGISRLGIDRGFSSSGAGFGSGSNYKSAPSRGVSHHGHGGMSGSHRGSQRGSRRGGGERDKPDPSSLTIPVDQVAPLQLSANRWQPKKLTEKPAETKGEDEEALLPPEVVQRKVKGSLNKMTLEKFDKISDQILEIAMQSRKENDGRTLKQVIQLTFEKATDEPNFSNMYARFARKMMDSIDDSIRDEGVLDKNNQPVRGGLLFRKYLLSRCQEDFERGWKANLPSGKAGEAEIMSDEYYVAAAIKRRGLGLVRFIGELFKLSMLSEKIMHECIKRLLGNVTDPEEEEIESLCRLLMTVGVNIDATEKGHAAMDVYVLRMETITKIPNLPSRIKFMLMDVMDSRKNGWAVKNEVEKGPKTIAEIHEEAERKKALAESQRPSSGRMHGRDMNRGDSRMGGRGSNPPFSSSDWSNNKDGYARLGQGIRGLKSGTQGSHGPTSLSSMLKGGSVSRTPSRQNSALRREQSVRAPPSNVAVTSANSFELLEEHDHDNDGGQKDSNSKTSS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationSSKPPSNTPKFSYAR
CCCCCCCCCCHHHHH
31.9929996109
20PhosphorylationSYARALASSQSNKSN
HHHHHHHHHHCCCCC
29.7524763107
71PhosphorylationESTGKITSEADTEKY
CCCCCCCCHHHHCHH
33.9725720772
80PhosphorylationADTEKYNSSKSPVNK
HHHCHHCCCCCCCCC
35.7321712547
81PhosphorylationDTEKYNSSKSPVNKE
HHCHHCCCCCCCCCC
33.2528889911
83PhosphorylationEKYNSSKSPVNKEGS
CHHCCCCCCCCCCCC
35.7128889911
123PhosphorylationANSSAERTSSQHQKP
CCCCCCCCCCCCCCC
25.0027738172
125PhosphorylationSSAERTSSQHQKPET
CCCCCCCCCCCCCCC
30.9429996109
132PhosphorylationSQHQKPETSSQIGKD
CCCCCCCCHHHCCCC
42.0524763107
133PhosphorylationQHQKPETSSQIGKDN
CCCCCCCHHHCCCCC
20.7025720772
134PhosphorylationHQKPETSSQIGKDNA
CCCCCCHHHCCCCCC
32.9825720772
169PhosphorylationTVPIQFGSITRNAAI
CCCEECCCEECCCCC
23.2927738172
199PhosphorylationVSSYSSKSQSVNSSV
CCCCCCCCCCCCCCC
29.6327738172
205PhosphorylationKSQSVNSSVTSNPPH
CCCCCCCCCCCCCCC
24.9827738172
208PhosphorylationSVNSSVTSNPPHTEE
CCCCCCCCCCCCCCC
45.2227738172
243PhosphorylationSASNTNTSPANGAPT
CCCCCCCCCCCCCCC
24.8821712547
250PhosphorylationSPANGAPTNKPSTDI
CCCCCCCCCCCCCCC
56.1721712547
270PhosphorylationATQTTQVSASNSPAL
CCCCEEEECCCCCCC
19.0327738172
272PhosphorylationQTTQVSASNSPALSG
CCEEEECCCCCCCCC
30.2727738172
363PhosphorylationTYMSNGRSANQSPRN
CCCCCCCCCCCCCCC
32.7325720772
367PhosphorylationNGRSANQSPRNNPQN
CCCCCCCCCCCCCCC
26.1525720772
441PhosphorylationNFPNMSRSGSQVSDQ
CCCCCCCCCCCCCCC
35.1729996109
443PhosphorylationPNMSRSGSQVSDQVV
CCCCCCCCCCCCCEE
28.7629996109
446PhosphorylationSRSGSQVSDQVVESP
CCCCCCCCCCEECCC
18.0629996109
452PhosphorylationVSDQVVESPNSSTLS
CCCCEECCCCCCCCC
20.1228889911
455PhosphorylationQVVESPNSSTLSPRN
CEECCCCCCCCCCCC
28.2528889911
456PhosphorylationVVESPNSSTLSPRNG
EECCCCCCCCCCCCC
39.7528889911
457PhosphorylationVESPNSSTLSPRNGF
ECCCCCCCCCCCCCC
30.9525720772
459PhosphorylationSPNSSTLSPRNGFAP
CCCCCCCCCCCCCHH
23.1528889911
496PhosphorylationVVPQKNASSPNPSET
EECCCCCCCCCCHHC
56.5824763107
497PhosphorylationVPQKNASSPNPSETN
ECCCCCCCCCCHHCC
26.7029996109
501PhosphorylationNASSPNPSETNSRAE
CCCCCCCHHCCCCCC
64.7924763107
503PhosphorylationSSPNPSETNSRAETP
CCCCCHHCCCCCCCC
42.7121712547
505PhosphorylationPNPSETNSRAETPTA
CCCHHCCCCCCCCCC
40.0428889911
509PhosphorylationETNSRAETPTAAPPQ
HCCCCCCCCCCCCCC
25.5928889911
511PhosphorylationNSRAETPTAAPPQIS
CCCCCCCCCCCCCCC
42.7629996109
518PhosphorylationTAAPPQISEEEASQR
CCCCCCCCHHHHHHH
33.4428889911
723PhosphorylationKSSAPLASSEANVDT
HCCCCCCCCCCCCCC
36.0729996109
724PhosphorylationSSAPLASSEANVDTS
CCCCCCCCCCCCCCC
34.8125720772
757PhosphorylationLKASEGKSTSSLSSP
HHCCCCCCCCCCCCC
44.3621712547
758PhosphorylationKASEGKSTSSLSSPS
HCCCCCCCCCCCCCC
26.3129996109
759PhosphorylationASEGKSTSSLSSPSH
CCCCCCCCCCCCCCC
36.0521712547
760PhosphorylationSEGKSTSSLSSPSHS
CCCCCCCCCCCCCCC
32.1529996109
762PhosphorylationGKSTSSLSSPSHSTS
CCCCCCCCCCCCCCC
41.9921712547
763PhosphorylationKSTSSLSSPSHSTSS
CCCCCCCCCCCCCCC
35.4024763107
765PhosphorylationTSSLSSPSHSTSSKR
CCCCCCCCCCCCCHH
31.8324763107
767PhosphorylationSLSSPSHSTSSKRDL
CCCCCCCCCCCHHHH
34.0324763107
768PhosphorylationLSSPSHSTSSKRDLL
CCCCCCCCCCHHHHH
31.4324763107
769PhosphorylationSSPSHSTSSKRDLLS
CCCCCCCCCHHHHHH
36.5624763107
770PhosphorylationSPSHSTSSKRDLLSG
CCCCCCCCHHHHHHH
31.6224763107
776PhosphorylationSSKRDLLSGLESLSL
CCHHHHHHHHHHHCC
48.9425720772
780PhosphorylationDLLSGLESLSLKTNP
HHHHHHHHHCCCCCC
28.4425720772
782PhosphorylationLSGLESLSLKTNPKS
HHHHHHHCCCCCCCH
36.7825720772
866PhosphorylationASAFSDKSSRGMYSS
HHHHCCCCCCCCCCC
30.2028889911
867PhosphorylationSAFSDKSSRGMYSSS
HHHCCCCCCCCCCCC
38.3029996109
874PhosphorylationSRGMYSSSRQSSRSG
CCCCCCCCCCCCCCC
28.5329996109
877PhosphorylationMYSSSRQSSRSGSNT
CCCCCCCCCCCCCCC
26.9729996109
878PhosphorylationYSSSRQSSRSGSNTH
CCCCCCCCCCCCCCC
23.3327738172
880PhosphorylationSSRQSSRSGSNTHSH
CCCCCCCCCCCCCCC
48.8228889911
882PhosphorylationRQSSRSGSNTHSHAG
CCCCCCCCCCCCCCC
39.5428889911
884PhosphorylationSSRSGSNTHSHAGPG
CCCCCCCCCCCCCCC
26.8428889911
886PhosphorylationRSGSNTHSHAGPGFG
CCCCCCCCCCCCCCC
17.0028889911
896PhosphorylationGPGFGGPSERKGISR
CCCCCCCCCCCCHHH
53.9925720772
902PhosphorylationPSERKGISRLGIDRG
CCCCCCHHHCCCCCC
30.0724763107
911PhosphorylationLGIDRGFSSSGAGFG
CCCCCCCCCCCCCCC
26.8128889911
912PhosphorylationGIDRGFSSSGAGFGS
CCCCCCCCCCCCCCC
30.4524763107
913PhosphorylationIDRGFSSSGAGFGSG
CCCCCCCCCCCCCCC
31.3128889911
919PhosphorylationSSGAGFGSGSNYKSA
CCCCCCCCCCCCCCC
36.4728889911
921PhosphorylationGAGFGSGSNYKSAPS
CCCCCCCCCCCCCCC
38.3928889911
923PhosphorylationGFGSGSNYKSAPSRG
CCCCCCCCCCCCCCC
14.1728889911
932PhosphorylationSAPSRGVSHHGHGGM
CCCCCCCCCCCCCCC
16.7629996109
942PhosphorylationGHGGMSGSHRGSQRG
CCCCCCCCCCCCCCC
11.6029996109
963PhosphorylationERDKPDPSSLTIPVD
CCCCCCCCCCEEEHH
45.4125720772
1279PhosphorylationLAESQRPSSGRMHGR
HHHHCCCCCCCCCCC
47.8429996109
1280PhosphorylationAESQRPSSGRMHGRD
HHHCCCCCCCCCCCC
32.8525720772
1300PhosphorylationSRMGGRGSNPPFSSS
CCCCCCCCCCCCCCC
44.8128889911
1328PhosphorylationQGIRGLKSGTQGSHG
HHHCCCCCCCCCCCC
52.7121712547
1333PhosphorylationLKSGTQGSHGPTSLS
CCCCCCCCCCCCCHH
18.5628889911
1337PhosphorylationTQGSHGPTSLSSMLK
CCCCCCCCCHHHHHC
47.0628889911
1340PhosphorylationSHGPTSLSSMLKGGS
CCCCCCHHHHHCCCC
17.3027738172
1347PhosphorylationSSMLKGGSVSRTPSR
HHHHCCCCCCCCCCH
26.1129996109
1351PhosphorylationKGGSVSRTPSRQNSA
CCCCCCCCCCHHCHH
20.3629996109
1353PhosphorylationGSVSRTPSRQNSALR
CCCCCCCCHHCHHHH
45.9829996109
1357PhosphorylationRTPSRQNSALRREQS
CCCCHHCHHHHHHHH
21.9729996109
1376PhosphorylationPSNVAVTSANSFELL
CCCEEEEECCHHHHH
20.8929996109
1379PhosphorylationVAVTSANSFELLEEH
EEEEECCHHHHHHHC
21.5829996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IF4G_SCHPO !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IF4G_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IF4G_SCHPO !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ULP2_SCHPOulp2physical
24818994

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IF4G_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-452; SER-455;SER-456; SER-459; SER-866; SER-882; THR-884; SER-886; SER-911;SER-919; SER-921; TYR-923 AND SER-1333, AND MASS SPECTROMETRY.

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