PPIL4_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPIL4_SCHPO
• UniProt AC: Q9UUE4
• Protein Name: Peptidyl-prolyl cis-trans isomerase cyp6
• Gene Name: cyp6
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 432
• Subcellular Localization: Nucleus .
• Protein Description: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)..
• Protein Sequence: MSVLIETTVGDLVIDLFVKEAPKTCENFLKLCKLKYYNFCPFYNIQHNYTCQTGDPLGPTGDGGRCVWNVLNKGTRFFKAEFNPSLVHNKMGLVSMSTATISSRDDKLLVCGSQFIITLSDNLEGLDERYPIYGQVAEGFDTLLKINDAICDEEGQPYRDIRIKHTIILDDPFEDPPDLVEPLRSPSPTPEQLATVRIGENEQIESETSEDKLQREKEMEAEAEAVTLEMIGDLPFAHVAPPENVLFVCKLNPVTQDEDLELIFSRFGKIISCQVIRDKETGDSLQYAFIEFDNKESVEKAYFKMQNVLIDDSRIHVDFSQSVARYRQYYNSNRDRKRSSSRSDDREYHRRSDGRYDRSNYRDDYRHRRKERDHRDDQSSFRNERFSNYYGDDRSYHKRRNTGNKNCDDHLRDKSPERRYRYDRRYRDDRYR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
166	Phosphorylation	RDIRIKHTIILDDPF CCEEEEEEEEECCCC	12.52	29996109
185	Phosphorylation	DLVEPLRSPSPTPEQ CCCCCCCCCCCCHHH	37.10	25720772
187	Phosphorylation	VEPLRSPSPTPEQLA CCCCCCCCCCHHHEE	42.52	29996109
189	Phosphorylation	PLRSPSPTPEQLATV CCCCCCCCHHHEEEE	43.74	29996109
195	Phosphorylation	PTPEQLATVRIGENE CCHHHEEEEEECCCC	20.93	29996109
206	Phosphorylation	GENEQIESETSEDKL CCCCHHCCCCCHHHH	48.05	28889911
208	Phosphorylation	NEQIESETSEDKLQR CCHHCCCCCHHHHHH	46.85	29996109
209	Phosphorylation	EQIESETSEDKLQRE CHHCCCCCHHHHHHH	39.48	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPIL4_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPIL4_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPIL4_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of PPIL4_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206, AND MASSSPECTROMETRY.
PubMed: 18257517