SPO15_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPO15_SCHPO
• UniProt AC: Q10411
• Protein Name: Sporulation-specific protein 15
• Gene Name: spo15
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1957
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body .
• Protein Description: Has a role in the initiation of spore membrane formation..
• Protein Sequence: MSNQSSSGSNTSDLDEESASSLVSSAASPFIDSDLETPRPNISRASTGQLAEDGDTSSQHEDSSEELKRQEVRGMRRHSDLSIDAKLGSSEGSTASSALPLTPRSPSNASWLLVRGGLLDSPILDINSVTQKSNLLNELKQVRSKLAALEHENGILSLQLSSSNKKDKNTSSVTTLTSEEDVSYFQKKLTNMESNFSAKQSEAYDLSRQLLTVTEKLDKKEKDYEKIKEDVSSIKASLAEEQASNKSLRGEQERLEKLLVSSNKTVSTLRQTENSLRAECKTLQEKLEKCAINEEDSKLLEELKHNVANYSDAIVHKDKLIEDLSTRISEFDNLKSERDTLSIKNEKLEKLLRNTIGSLKDSRTSNSQLEEEMVELKESNRTIHSQLTDAESKLSSFEQENKSLKGSIDEYQNNLSSKDKMVKQVSSQLEEARSSLAHATGKLAEINSERDFQNKKIKDFEKIEQDLRACLNSSSNELKEKSALIDKKDQELNNLREQIKEQKKVSESTQSSLQSLQRDILNEKKKHEVYESQLNELKGELQTEISNSEHLSSQLSTLAAEKEAAVATNNELSESKNSLQTLCNAFQEKLAKSVMQLKENEQNFSSLDTSFKKLNESHQELENNHQTITKQLKDTSSKLQQLQLERANFEQKESTLSDENNDLRTKLLKLEESNKSLIKKQEDVDSLEKNIQTLKEDLRKSEEALRFSKLEAKNLREVIDNLKGKHETLEAQRNDLHSSLSDAKNTNAILSSELTKSSEDVKRLTANVETLTQDSKAMKQSFTSLVNSYQSISNLYHELRDDHVNMQSQNNTLLESESKLKTDCENLTQQNMTLIDNVQKLMHKHVNQESKVSELKEVNGKLSLDLKNLRSSLNVAISDNDQILTQLAELSKNYDSLEQESAQLNSGLKSLEAEKQLLHTENEELHIRLDKLTGKLKIEESKSSDLGKKLTARQEEISNLKEENMSQSQAITSVKSKLDETLSKSSKLEADIEHLKNKVSEVEVERNALLASNERLMDDLKNNGENIASLQTEIEKKRAENDDLQSKLSVVSSEYENLLLISSQTNKSLEDKTNQLKYIEKNVQKLLDEKDQRNVELEELTSKYGKLGEENAQIKDELLALRKKSKKQHDLCANFVDDLKEKSDALEQLTNEKNELIVSLEQSNSNNEALVEERSDLANRLSDMKKSLSDSDNVISVIRSDLVRVNDELDTLKKDKDSLSTQYSEVCQDRDDLLDSLKGCEESFNKYAVSLRELCTKSEIDVPVSEILDDNFVFNAGNFSELSRLTVLSLENYLDAFNQVNFKKMELDNRLTTTDAEFTKVVADLEKLQHEHDDWLIQRGDLEKALKDSEKNFLRKEAEMTENIHSLEEGKEETKKEIAELSSRLEDNQLATNKLKNQLDHLNQEIRLKEDVLKEKESLIISLEESLSNQRQKESSLLDAKNELEHMLDDTSRKNSSLMEKIESINSSLDDKSFELASAVEKLGALQKLHSESLSLMENIKSQLQEAKEKIQVDESTIQELDHEITASKNNYEGKLNDKDSIIRDLSENIEQLNNLLAEEKSAVKRLSTEKESEILQFNSRLADLEYHKSQVESELGRSKLKLASTTEELQLAENERLSLTTRMLDLQNQVKDLSNIKDSLSEDLRTLRSLEDSVASLQKECKIKSNTVESLQDVLTSVQARNAELEDEVSRSVDKIRRRDDRCEHLSGKLKKLHSQLEEQHETFFRAEQQRMTQLGFLKETVKKQEKLLKKLNLRQEQLIPRSSILVYESYIRDIEKEIIVLQERLNGIELSQQLPKGYFGYFFKTNRVEMEVLDSFKQQVAKLQFLAGAEFIVKFKEDLEKCAAEEKEKQATFDNYSEKVENLGKSIEALYFALNREISFRKSLALSKSAYHNLLVRDSPKFNPDSQITYSIPVTNTKQSLLRSAILCVISLQRLRLLGQRHSFCEEVIENLSCV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	RPNISRASTGQLAED CCCCCCCCCCCCCCC	31.77	29996109
47	Phosphorylation	PNISRASTGQLAEDG CCCCCCCCCCCCCCC	28.14	29996109
56	Phosphorylation	QLAEDGDTSSQHEDS CCCCCCCCCCCCCCC	35.49	25720772
57	Phosphorylation	LAEDGDTSSQHEDSS CCCCCCCCCCCCCCH	32.51	29996109
58	Phosphorylation	AEDGDTSSQHEDSSE CCCCCCCCCCCCCHH	37.33	29996109
63	Phosphorylation	TSSQHEDSSEELKRQ CCCCCCCCHHHHHHH	36.34	25720772
64	Phosphorylation	SSQHEDSSEELKRQE CCCCCCCHHHHHHHH	47.62	25720772
79	Phosphorylation	VRGMRRHSDLSIDAK HHHHHHCCCCCEEEE	38.13	28889911
82	Phosphorylation	MRRHSDLSIDAKLGS HHHCCCCCEEEECCC	24.34	29996109
93	Phosphorylation	KLGSSEGSTASSALP ECCCCCCCCCCCCCC	19.42	21712547
94	Phosphorylation	LGSSEGSTASSALPL CCCCCCCCCCCCCCC	41.22	29996109
96	Phosphorylation	SSEGSTASSALPLTP CCCCCCCCCCCCCCC	19.07	21712547
102	Phosphorylation	ASSALPLTPRSPSNA CCCCCCCCCCCCCCC	18.08	25720772
105	Phosphorylation	ALPLTPRSPSNASWL CCCCCCCCCCCCCEE	33.61	28889911
107	Phosphorylation	PLTPRSPSNASWLLV CCCCCCCCCCCEEEE	46.40	25720772
110	Phosphorylation	PRSPSNASWLLVRGG CCCCCCCCEEEEECC	23.62	25720772
121	Phosphorylation	VRGGLLDSPILDINS EECCCCCCCCCCHHH	17.51	25720772
416	Phosphorylation	DEYQNNLSSKDKMVK HHHHHCCCHHHHHHH	37.15	24763107
417	Phosphorylation	EYQNNLSSKDKMVKQ HHHHCCCHHHHHHHH	48.30	24763107
863	Phosphorylation	KEVNGKLSLDLKNLR HHHCCEEEECHHHHH	24.27	25720772
943	Phosphorylation	LKIEESKSSDLGKKL EEECCCCCCHHHHHH	38.06	28889911
951	Phosphorylation	SDLGKKLTARQEEIS CHHHHHHHHHHHHHH	28.77	28889911
1187	Phosphorylation	RLSDMKKSLSDSDNV HHHHHHHHCCCCCCH	27.82	25720772
1189	Phosphorylation	SDMKKSLSDSDNVIS HHHHHHCCCCCCHHH	42.00	25720772
1191	Phosphorylation	MKKSLSDSDNVISVI HHHHCCCCCCHHHHH	27.92	25720772
1516	Phosphorylation	EKIQVDESTIQELDH HHHCCCHHHHHHHHH	26.75	21712547
1657	Phosphorylation	SLEDSVASLQKECKI HHHHHHHHHHHHHCC	29.22	28889911
1868	Phosphorylation	KVENLGKSIEALYFA HHHHHHHHHHHHHHH	24.70	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPO15_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPO15_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPO15_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SAD1_SCHPO	sad1	physical	10639340

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105, AND MASSSPECTROMETRY.
PubMed: 18257517