PPIL2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPIL2_SCHPO
• UniProt AC: Q09928
• Protein Name: Peptidyl-prolyl cis-trans isomerase cyp8 {ECO:0000305}
• Gene Name: cyp8
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 516
• Subcellular Localization: Nucleus .
• Protein Description: May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins..
• Protein Sequence: MGKNTDKLYITQTEHSGVHGWHGGMSGIAQKNSTTSYKQLPFNYCSLSLQPFNHPCCLVDETKQAIIFDFRFIVPWLRKHGTNPINGQKASMSDLIKLKFAKNSAEEYCDPVTMKSFTRFSHIVAIRSTGNCFSWDTIERLNIKPKHWRDLVNEEQFTRDDIITIQDPHNVENRDFSAIQKQKETARDEKITKAKIALQASRAKSTESTSSPELSHSLDSSKSIASDMPIHRASHTTGYAAASLTSTSFTPVTKNERAIIAEEDYMLNHTRIKHKGYARIVTNHGEINIELHTDYAPHAVYNFVQLAKQGYYRNTIFHRNIARFMIQGGDPSGTGRGGQSIWGKPFKDEFCNPLKHDDRGIISMANRGKNTNGSQFFILYGPAKHLDNKHTIFGRVVGGLNVLDALEKVPTNSNDHPKLPIKLEDIIIFVDPFEEWKKDEREKEKRKRQEEEEENNLDRTSWTGRDLSASSTDHSLNASVGKYLKKEVSLEEKTFTSTVNPKKKKARTGFGNFDAW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
205	Phosphorylation	LQASRAKSTESTSSP HHHHHCCCCCCCCCH	36.10	25720772
206	Phosphorylation	QASRAKSTESTSSPE HHHHCCCCCCCCCHH	32.99	25720772
208	Phosphorylation	SRAKSTESTSSPELS HHCCCCCCCCCHHHH	33.41	25720772
209	Phosphorylation	RAKSTESTSSPELSH HCCCCCCCCCHHHHH	27.30	24763107
210	Phosphorylation	AKSTESTSSPELSHS CCCCCCCCCHHHHHC	53.85	25720772
211	Phosphorylation	KSTESTSSPELSHSL CCCCCCCCHHHHHCC	23.60	29996109
215	Phosphorylation	STSSPELSHSLDSSK CCCCHHHHHCCCCCC	14.90	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPIL2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPIL2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPIL2_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of PPIL2_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.