TEL2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TEL2_SCHPO
• UniProt AC: Q9P3W5
• Protein Name: DNA replication checkpoint protein tel2
• Gene Name: tel2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 868
• Subcellular Localization: Cytoplasm .
• Protein Description: Component of the TORC1 and TORC2 complexes required for the regulation of the cellular respons to changes in available nutrients. Required for normal entry into S phase. Regulates activation of the DNA replication checkpoint. Required for efficient phosphorylation of mrc1, which is essential for the activation of cds1 kinase. Plays also an important role in genome stability..
• Protein Sequence: MKSFASELSKPIQKPRLKEILKELQHIGVPSPCNLRLYHELISVIVPTFWNGKINSEIDFLLAKCFSTLLGLKLLCVRLDNFVQEANLQNIHLVTVYLELLEKAFECIDLDDNCKLIWESTVLSDHQKQSLWTEFIFFLGNFKITNSMSAAMLTFKVYDDSKRLKASSMADYIGVLSSKLACIISKPAVKTPEIYSKLFHYLLHSSNLKAFINPLIPLTQKFCVQLQKLFADLTVSDQMLFLNQLLLEHNTKYPTNFSYSTARDDRITGSLATLLRLNFSSTHFLRLIEFYWGVPTNLIIKRVEVVCSSISYKESDKKELEKTVDSLFNIWSNAQFLRSYTLLAQESLTIYLLLFIPKLEAKYLNNLSKSLMFSNAISCRLDSLDDDIRMHGMIMAEVISTYSGVSLSNPLAFDVPIMKTTKAKVLKSLSSLKDEFLPIEILNDESVIAETSIEKEETNVTHLEKPVISKNDDLIRGDDLEPYDFPDIDSEDTDDDPTVSRSKTHSPVYVQDLCKMLKDTESFEKQRVALENASKLIKRKSAFGTELRDHADELLQTLISLQNRFDLMNFDEMQMTAIVELLLTCLDICGPVICTNLFVSDYSMRQKILILSCISLAASKFNDDDNERLFPSQLLPGNLHDQFYSPTIEKISDELERKLVFPVMSECKDYAEGPKFLQTRYISKQSEIESKKPLPKANRLSLKVDKSLFLLLTSGYMLASRKTAFIEPLFLVYYLKTLGILFFETFTSKIEGANRMLREYVDVLNEVCRLRSDTPEVNEGLLFSFLAILEISSGRTLANEFGKHLLFFEAYTKFLFESPDQGEKVKSLSAAVLILFENKLSEFRTLALEKLLDDSAPLVPERFGLAGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MKSFASELSK -----CCCHHHHHCC	25.42	27738172
6	Phosphorylation	--MKSFASELSKPIQ --CCCHHHHHCCCCC	36.74	27738172
490	Phosphorylation	YDFPDIDSEDTDDDP CCCCCCCCCCCCCCC	37.39	28889911
493	Phosphorylation	PDIDSEDTDDDPTVS CCCCCCCCCCCCCCC	36.96	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TEL2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TEL2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TEL2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TTI1_SCHPO	tti1	physical	18076573
YG0H_SCHPO	tti2	physical	18076573
TRA1_SCHPO	tra1	physical	18076573
TOR2_SCHPO	tor2	physical	18076573
WAT1_SCHPO	pop3	physical	18076573
TOR1_SCHPO	tor1	physical	18076573
RAD3_SCHPO	rad3	physical	18076573
ATM_SCHPO	tel1	physical	18076573
YAMB_SCHPO	tra2	physical	18076573
TTI1_SCHPO	tti1	physical	20801936
YG0H_SCHPO	tti2	physical	20801936
MFR1_SCHPO	mfr1	genetic	22681890
SWD3_SCHPO	swd3	genetic	22681890
ALF1_SCHPO	alf1	genetic	22681890
PDH1_SCHPO	pdh1	genetic	22681890
YI47_SCHPO	SPBC1348.07	genetic	22681890
GHT4_SCHPO	ght4	genetic	22681890
TRA1_SCHPO	tra1	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-490, AND MASSSPECTROMETRY.
PubMed: 18257517