GEF1_SCHPO - dbPTM
GEF1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GEF1_SCHPO
UniProt AC Q09763
Protein Name Rho guanine nucleotide exchange factor gef1
Gene Name gef1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 753
Subcellular Localization Cell septum .
Protein Description Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth, via modulation of cdc42-shk1-orb6 signaling, and septum formation. Stimulates guanine nucleotide exchange of cdc42..
Protein Sequence METLKADLSDMSDSPEYFETLANRDLPRLPGTSKLHRAACIKRKSINLSLPSNSYSLSYRQSDDTDGDVSESQSEYRLSSGRRSRASFARALQDPQTPNTPPVSSQHRRFFSEGSFNLPNSNMSHSLNGDSTASNSSTLTPNRIYGDRNRQDYAQSSRYTLPSLPSSPSYNCPTTLRKIHTNTSSNGTSRRVSGLGSFMAQNSSETSSNRTSAYLPGSSTDEQEKRSSVTLASMPSSHSSTASLLSPLDTTSFSTKLDSTILALETDESLSRTISYATTSLPSTPGKRLSKESLAMSEASSINPEYKRIKKRANLIKELVTTEAAYLNDLIAIQQSYGLRVKECSALNPVDAQTVFGDIESLLTFTVEFHSRLYQAGEGSWRVNLDTQLIDPLPCNLGLIFLESLSEIGQIYTGYCNRQDSVFKIITKWREKPATASWIMEGDKIVQKYTNAWDLGSLIIKPLQRLLKYPLLLQKIIDVTPESSSERPDLVLSYQLLQELISGINQKQKPSHKRGSLSASHKRDAAWSLLYKATSNKSRPTTTSTELKTDARLNFQRQVLQDFRQRFAILKALHATLETWYVTVHRGFSVFEKVLAELEGLSALEPEDKPVDTWRKYHLLAHMMTANLPSQIQTSLNSSILNPITNILRVIQKVIQFIISAEFVIPAQKLEAISTLVEKEFHSVVYHFIGIQRSLYENYAQGFLFLIPQDMRDSILEETQDYAELVRAFEPMHYDDEVLLEELMKSVSLAARV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationETLKADLSDMSDSPE
CCCCCCHHCCCCCHH		31.6424763107
12PhosphorylationKADLSDMSDSPEYFE
CCCHHCCCCCHHHHH		39.6724763107
14PhosphorylationDLSDMSDSPEYFETL
CHHCCCCCHHHHHHH		16.6021712547
45PhosphorylationAACIKRKSINLSLPS
HHHEECCEEEEECCC		22.2729996109
62PhosphorylationYSLSYRQSDDTDGDV
EECEEEECCCCCCCC		28.5825720772
65PhosphorylationSYRQSDDTDGDVSES
EEEECCCCCCCCCHH		47.0425720772
70PhosphorylationDDTDGDVSESQSEYR
CCCCCCCCHHHHHHC		35.9525720772
72PhosphorylationTDGDVSESQSEYRLS
CCCCCCHHHHHHCCC		31.3425720772
74PhosphorylationGDVSESQSEYRLSSG
CCCCHHHHHHCCCCC		45.9725720772
97PhosphorylationRALQDPQTPNTPPVS
HHHCCCCCCCCCCCC		24.7225720772
100PhosphorylationQDPQTPNTPPVSSQH
CCCCCCCCCCCCHHC		30.1225720772
112PhosphorylationSQHRRFFSEGSFNLP
HHCHHCCCCCCCCCC		38.0329996109
160PhosphorylationYAQSSRYTLPSLPSS
HHHHCCCCCCCCCCC		30.9629996109
163PhosphorylationSSRYTLPSLPSSPSY
HCCCCCCCCCCCCCC		56.9029996109
166PhosphorylationYTLPSLPSSPSYNCP
CCCCCCCCCCCCCCC		61.2429996109
167PhosphorylationTLPSLPSSPSYNCPT
CCCCCCCCCCCCCCC		18.8725720772
169PhosphorylationPSLPSSPSYNCPTTL
CCCCCCCCCCCCCCE		30.8129996109
193PhosphorylationNGTSRRVSGLGSFMA
CCCEEEECCCCHHHC		26.8729996109
197PhosphorylationRRVSGLGSFMAQNSS
EEECCCCHHHCCCCC		19.5229996109
233PhosphorylationRSSVTLASMPSSHSS
HHCCEEECCCCCCCC		34.0525720772
243PhosphorylationSSHSSTASLLSPLDT
CCCCCCHHHCCCCCC		29.9025720772
269PhosphorylationLALETDESLSRTISY
EEEECCHHHHHHHHH		34.1625720772
271PhosphorylationLETDESLSRTISYAT
EECCHHHHHHHHHHH		36.3425720772
278PhosphorylationSRTISYATTSLPSTP
HHHHHHHHCCCCCCC		14.5325720772
280PhosphorylationTISYATTSLPSTPGK
HHHHHHCCCCCCCCC		33.6529996109
283PhosphorylationYATTSLPSTPGKRLS
HHHCCCCCCCCCCCC		53.1529996109
284PhosphorylationATTSLPSTPGKRLSK
HHCCCCCCCCCCCCH		33.8429996109
290PhosphorylationSTPGKRLSKESLAMS
CCCCCCCCHHHHHHH		38.1124763107
293PhosphorylationGKRLSKESLAMSEAS
CCCCCHHHHHHHHHH		25.7624763107
297PhosphorylationSKESLAMSEASSINP
CHHHHHHHHHHHCCH		25.1424763107
300PhosphorylationSLAMSEASSINPEYK
HHHHHHHHHCCHHHH		27.9221712547
528PhosphorylationHKRDAAWSLLYKATS
HHHHHHHHHHHHHHC		12.0825720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GEF1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GEF1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GEF1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDC42_SCHPOcdc42genetic
12972551
CDC42_SCHPOcdc42physical
12972551
CDC42_SCHPOcdc42physical
12529446
HOB3_SCHPOhob3physical
17363901
CDC42_SCHPOcdc42physical
17363901
GEF3_SCHPOgef3genetic
24947517
GEF1_SCHPOgef1physical
26771498
WRIP1_SCHPOSPAC26H5.02cphysical
26771498
ATP11_SCHPOatp11physical
26771498
PRP40_SCHPOusp104physical
26771498
YEK9_SCHPOSPAC4F10.09cphysical
26771498
YPP1_SCHPOSPAC637.04physical
26771498
MDV1_SCHPOcaf4physical
26771498
MUG79_SCHPOspo7physical
26771498
CYK3_SCHPOcyk3physical
26771498
PCK2_SCHPOpck2physical
26771498
MCM10_SCHPOcdc23physical
26771498
YH7G_SCHPOSPBC16G5.16physical
26771498
YHFA_SCHPOSPBC1734.10cphysical
26771498
RAL2_SCHPOral2physical
26771498
YHP4_SCHPOrmn1physical
26771498
SEC6_SCHPOsec6physical
26771498
CSL4_SCHPOcsl4physical
26771498
RGA4_SCHPOrga4genetic
26246599
FOR3_SCHPOfor3genetic
26941334
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GEF1_SCHPO

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Related Literatures of Post-Translational Modification

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