RGA4_SCHPO - dbPTM
RGA4_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RGA4_SCHPO
UniProt AC O74360
Protein Name Probable Rho-type GTPase-activating protein 4
Gene Name rga4
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 933
Subcellular Localization
Protein Description GTPase-activating protein for Rho-type proteins..
Protein Sequence MNSGTTLHLDRLSLETPSERTCFCIKCWESVPSTSQVWFGGKCWHSDCFKCVNCNKKLDPSSEDFSQDDQKQIFCKLCVDICNGCSTPICEFNAVSNSQANHPCCSNCRAFINSNAFGKFKGQHYCLPCLRKQDEENQKAVMESASGFIPLRNIAQTAENTSLTGQNQGFQNPHFIASDSPSSVLSGRMQNTSSPTNSLRPQLKVQTNGYETPGDINSAKSYKDIQKDFLLKPKNSFVKTSPSPLANGPSFRSANASPFDSCDSFHSGSSIPIEPVSSRQSSVVNNNSVQQPVAYHAFVQSPTENGTLPQLPKNESVVNPPPLRRSSTMNYKSVSTTTSPSKYGYVSGRIALSPIHLRGALRDVTNKCNLKVPRNRNSLSNLDEYYVNGLESDETPTKARFPRYPTVFNKLDDKRLSSEPNGLKKRLTNSSNYEASPRAKSLNLSQVSLHQACEPEYNRSSLVRASDVFTSNVFDATEESANELAIRISELQAEVGTLLLEATSLASIIEQQTPVSPEAFKQELVADLNYRLDYLRKSFQPELSTLLLRRDALSTTVSKLQNAYSTVMEETAYLNVKNTELVSLNNQLERELAYLREQQHKKRTSSSFGIFNNDKKSNRTISTPSPRESFSRLQMVASSLGFRPKDNKDKESGGYNKRNSKIDLKKSFSKRFHWKRDSPHMSSTPSISEEHLASEEQEDFVPAVGHCKLCGKYSNELRAHYQDCVSSTIDRQYQSKKSESPVWALNPDDFDQNRLTLLRVPTLIVSCINFIESYGMDFEGLYRKSGATSQMKKIVALLRNEDTVLDPSEDISAVTSVFKQYLRNLPNPIITYDQYFPFITAANCASFQDKLDGFIMVIKSLPPAHAEILQLIIRHLARVAAYSHANRMTSKNLAVVFSPTLIRDPDNSRDVIDMTVKNYSLAFLIDHVHEVFA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MNSGTTLHLD
-----CCCCCEEEEE		35.9029996109
5Phosphorylation---MNSGTTLHLDRL
---CCCCCEEEEEEC		26.4629996109
6Phosphorylation--MNSGTTLHLDRLS
--CCCCCEEEEEECC		18.7329996109
13PhosphorylationTLHLDRLSLETPSER
EEEEEECCCCCCCCC		25.6729996109
86PhosphorylationVDICNGCSTPICEFN
HHHCCCCCCCCHHHH		38.3227738172
178PhosphorylationQNPHFIASDSPSSVL
CCCCEEECCCCHHHH		33.5327738172
192PhosphorylationLSGRMQNTSSPTNSL
HCCCCCCCCCCCCCC		17.4329996109
193PhosphorylationSGRMQNTSSPTNSLR
CCCCCCCCCCCCCCC		41.7028889911
194PhosphorylationGRMQNTSSPTNSLRP
CCCCCCCCCCCCCCC		33.4328889911
196PhosphorylationMQNTSSPTNSLRPQL
CCCCCCCCCCCCCCE		39.1125720772
198PhosphorylationNTSSPTNSLRPQLKV
CCCCCCCCCCCCEEE		28.3828889911
212PhosphorylationVQTNGYETPGDINSA
EECCCCCCCCCCCCC		24.8821712547
218PhosphorylationETPGDINSAKSYKDI
CCCCCCCCCCHHHHH		37.0924763107
221PhosphorylationGDINSAKSYKDIQKD
CCCCCCCHHHHHHHC		36.8125720772
222PhosphorylationDINSAKSYKDIQKDF
CCCCCCHHHHHHHCC		16.3925720772
236PhosphorylationFLLKPKNSFVKTSPS
CCCCCCCCCCCCCCC		37.2325720772
240PhosphorylationPKNSFVKTSPSPLAN
CCCCCCCCCCCCCCC		40.3429996109
241PhosphorylationKNSFVKTSPSPLANG
CCCCCCCCCCCCCCC		20.0529996109
243PhosphorylationSFVKTSPSPLANGPS
CCCCCCCCCCCCCCC		32.1129996109
250PhosphorylationSPLANGPSFRSANAS
CCCCCCCCCCCCCCC		34.3929996109
253PhosphorylationANGPSFRSANASPFD
CCCCCCCCCCCCCCC		24.7025720772
257PhosphorylationSFRSANASPFDSCDS
CCCCCCCCCCCCCCC		26.3828889911
261PhosphorylationANASPFDSCDSFHSG
CCCCCCCCCCCCCCC		21.8725720772
326PhosphorylationNPPPLRRSSTMNYKS
CCCCCCCCCCCCCEE		24.5924763107
327PhosphorylationPPPLRRSSTMNYKSV
CCCCCCCCCCCCEEC		29.8421712547
328PhosphorylationPPLRRSSTMNYKSVS
CCCCCCCCCCCEECC		15.6421712547
331PhosphorylationRRSSTMNYKSVSTTT
CCCCCCCCEECCCCC		8.2024763107
333PhosphorylationSSTMNYKSVSTTTSP
CCCCCCEECCCCCCH		15.7925720772
335PhosphorylationTMNYKSVSTTTSPSK
CCCCEECCCCCCHHH		27.4224763107
336PhosphorylationMNYKSVSTTTSPSKY
CCCEECCCCCCHHHH		31.7521712547
337PhosphorylationNYKSVSTTTSPSKYG
CCEECCCCCCHHHHC		20.1225720772
338PhosphorylationYKSVSTTTSPSKYGY
CEECCCCCCHHHHCE		38.4324763107
339PhosphorylationKSVSTTTSPSKYGYV
EECCCCCCHHHHCEE		25.6921712547
341PhosphorylationVSTTTSPSKYGYVSG
CCCCCCHHHHCEECC		37.9725720772
353PhosphorylationVSGRIALSPIHLRGA
ECCEEEECCHHHHHH		16.8828889911
378PhosphorylationKVPRNRNSLSNLDEY
CCCCCCCCCCCCHHH		29.9125720772
380PhosphorylationPRNRNSLSNLDEYYV
CCCCCCCCCCHHHHH		34.8624763107
385PhosphorylationSLSNLDEYYVNGLES
CCCCCHHHHHCCCCC		16.6321712547
386PhosphorylationLSNLDEYYVNGLESD
CCCCHHHHHCCCCCC		5.8421712547
392PhosphorylationYYVNGLESDETPTKA
HHHCCCCCCCCCCCC		45.8729996109
395PhosphorylationNGLESDETPTKARFP
CCCCCCCCCCCCCCC		41.0524763107
397PhosphorylationLESDETPTKARFPRY
CCCCCCCCCCCCCCC		44.7621712547
417PhosphorylationKLDDKRLSSEPNGLK
HCCCCCCCCCCCCHH		36.3725720772
418PhosphorylationLDDKRLSSEPNGLKK
CCCCCCCCCCCCHHH		62.7625720772
428PhosphorylationNGLKKRLTNSSNYEA
CCHHHHHCCCCCCCC		36.7721712547
430PhosphorylationLKKRLTNSSNYEASP
HHHHHCCCCCCCCCH		18.0921712547
431PhosphorylationKKRLTNSSNYEASPR
HHHHCCCCCCCCCHH		45.5625720772
433PhosphorylationRLTNSSNYEASPRAK
HHCCCCCCCCCHHHH		18.1521712547
436PhosphorylationNSSNYEASPRAKSLN
CCCCCCCCHHHHCCC		11.7224763107
441PhosphorylationEASPRAKSLNLSQVS
CCCHHHHCCCHHHHH		22.8529996109
445PhosphorylationRAKSLNLSQVSLHQA
HHHCCCHHHHHHHHH		27.7129996109
448PhosphorylationSLNLSQVSLHQACEP
CCCHHHHHHHHHCCC		16.7028889911
604PhosphorylationEQQHKKRTSSSFGIF
HHHHHCCCCCCCCCC		41.6724763107
605PhosphorylationQQHKKRTSSSFGIFN
HHHHCCCCCCCCCCC		28.1921712547
606PhosphorylationQHKKRTSSSFGIFNN
HHHCCCCCCCCCCCC		29.1329996109
607PhosphorylationHKKRTSSSFGIFNND
HHCCCCCCCCCCCCC		27.5321712547
622PhosphorylationKKSNRTISTPSPRES
CCCCCEECCCCHHHH		33.3825720772
623PhosphorylationKSNRTISTPSPRESF
CCCCEECCCCHHHHH		24.7629996109
625PhosphorylationNRTISTPSPRESFSR
CCEECCCCHHHHHHH		36.3628889911
629PhosphorylationSTPSPRESFSRLQMV
CCCCHHHHHHHHHHH		29.7825720772
638PhosphorylationSRLQMVASSLGFRPK
HHHHHHHHHCCCCCC		18.0629996109
639PhosphorylationRLQMVASSLGFRPKD
HHHHHHHHCCCCCCC		23.8329996109
678PhosphorylationRFHWKRDSPHMSSTP
HCCCCCCCCCCCCCC		22.2729996109
682PhosphorylationKRDSPHMSSTPSISE
CCCCCCCCCCCCCCH		28.2029996109
683PhosphorylationRDSPHMSSTPSISEE
CCCCCCCCCCCCCHH		36.4429996109
684PhosphorylationDSPHMSSTPSISEEH
CCCCCCCCCCCCHHH		17.4729996109
686PhosphorylationPHMSSTPSISEEHLA
CCCCCCCCCCHHHHC		38.5429996109
688PhosphorylationMSSTPSISEEHLASE
CCCCCCCCHHHHCCH		41.0729996109
694PhosphorylationISEEHLASEEQEDFV
CCHHHHCCHHHHCCC		48.2929996109
738PhosphorylationRQYQSKKSESPVWAL
HHHHCCCCCCCCEEC		47.2228889911
740PhosphorylationYQSKKSESPVWALNP
HHCCCCCCCCEECCH		31.6728889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RGA4_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RGA4_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RGA4_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDC42_SCHPOcdc42physical
18328707
CDC42_SCHPOcdc42genetic
18328707
RHO2_SCHPOrho2physical
20164182
RHO2_SCHPOrho2genetic
20164182
PCK2_SCHPOpck2genetic
20164182
POM1_SCHPOpom1genetic
20164182
SPM1_SCHPOpmk1genetic
20164182
RGA7_SCHPOrga7genetic
20164182
SPM1_SCHPOpmk1genetic
21057634
FOR3_SCHPOfor3genetic
17377067
SCD1_SCHPOscd1genetic
21849474
GEF1_SCHPOgef1genetic
21849474
SCD2_SCHPOscd2genetic
21849474
POM1_SCHPOpom1physical
23615447
RGA4_SCHPOrga4physical
26771498
IMDH_SCHPOgua1physical
26771498
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RGA4_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-353; SER-625; SER-738AND SER-740, AND MASS SPECTROMETRY.

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