RGA7_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RGA7_SCHPO
• UniProt AC: O94466
• Protein Name: Probable Rho-GTPase-activating protein 7
• Gene Name: rga7
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 695
• Protein Sequence: MLSAPSSSTTPASPPTSPPNTTSSDDFAVLKEPKVEAILNSELGLAILNDRIKDYLLTCKELAGFFKKRSILEEESGKNLQKLAKSYLETFQSKHHSPQSFSASVITSMEIHEQLANHSLTLQKTLSAFSDQVIEFHKNAERKRKSIKEYAKKQENAYLEAVMQMDKSKSRFKGAETEYNRALDNKNTGDSQKKVGFFKPKSNAQLTKLEDEARLKAENAESDMHSKIENAQNVQKQLLCIHRPNYIKQFFSLQREIESSLIANYLRYTKLCESNTLLNGLTIRPQKPTPTNCGLQHALDNINANTDFVQYVLHASIKHEDNKNPTDASKTKIIQPPSSYGTGSSAGKTNPPVNPTIKVTAAIPSPLQNTNPAPSTFPNPSVASPAFPNSSTSNPSTAPASASPLASTLKPSTANDTNGSSSSSSSNPRTSSPLASNAENKPPVAQQSPPVLLPTLPPIQTTTIQTSREVAPPPSSINSNRAASPFRPTSVSPQPSSPTKSLLFGARLDAIILREHSNIPNIVMQCTSQVENFGLNLQGIYRVPSSSARVNMLRSQFENNPLLQLHTPEDYENDVHAVADLLKIFFRELREPLIPDNHQRDFIDAGNVEDESRRRDAVHRAINDLPDANYSTIRHLTIHLAKIKENSDVNKMSTNNLAIIWGPTIIKQATIPEISSFSRTIEILIDYCFTIFDYD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
430	Phosphorylation	SSSSNPRTSSPLASN CCCCCCCCCCCCCCC	34.51	29996109
436	Phosphorylation	RTSSPLASNAENKPP CCCCCCCCCCCCCCC	44.23	29996109
448	Phosphorylation	KPPVAQQSPPVLLPT CCCCCCCCCCEECCC	21.06	29996109
475	Phosphorylation	REVAPPPSSINSNRA CCCCCCCCCCCCCCC	50.01	29996109
476	Phosphorylation	EVAPPPSSINSNRAA CCCCCCCCCCCCCCC	31.40	25720772
479	Phosphorylation	PPPSSINSNRAASPF CCCCCCCCCCCCCCC	26.48	29996109
484	Phosphorylation	INSNRAASPFRPTSV CCCCCCCCCCCCCCC	24.48	28889911
489	Phosphorylation	AASPFRPTSVSPQPS CCCCCCCCCCCCCCC	37.19	29996109
490	Phosphorylation	ASPFRPTSVSPQPSS CCCCCCCCCCCCCCC	24.23	29996109
492	Phosphorylation	PFRPTSVSPQPSSPT CCCCCCCCCCCCCCC	20.00	28889911
496	Phosphorylation	TSVSPQPSSPTKSLL CCCCCCCCCCCHHHH	43.64	28889911
497	Phosphorylation	SVSPQPSSPTKSLLF CCCCCCCCCCHHHHH	43.18	28889911
499	Phosphorylation	SPQPSSPTKSLLFGA CCCCCCCCHHHHHHC	34.90	29996109
501	Phosphorylation	QPSSPTKSLLFGARL CCCCCCHHHHHHCCH	32.55	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RGA7_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RGA7_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RGA7_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPM1_SCHPO	pmk1	genetic	20164182
CDC15_SCHPO	cdc15	genetic	25052092
IMP2_SCHPO	imp2	genetic	25052092
INN1_SCHPO	fic1	physical	25052092
MYO2_SCHPO	myo2	genetic	25977474
CDC12_SCHPO	cdc12	genetic	25977474
CDC15_SCHPO	cdc15	genetic	25977474
RNG2_SCHPO	rng2	genetic	25977474

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-496 AND SER-497, ANDMASS SPECTROMETRY.
PubMed: 18257517