SCD1_SCHPO - dbPTM
SCD1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SCD1_SCHPO
UniProt AC P40995
Protein Name Rho guanine nucleotide exchange factor scd1
Gene Name scd1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 872
Subcellular Localization Nucleus. Cytoplasm. Located at the growing cell ends and tips of conjugation tubes.
Protein Description Required for mating and morphogenesis. May contain a cryptic binding site for cdc42 that is enhanced by binding Ras. Interacts directly with scd2. Promotes the exchange of cdc42-bound GDP by GTP. Involved in septation and stimulates the elongation of conjugation tubes..
Protein Sequence MAYFQDRKTSSRSLPSYINHSTQNLVGPRKDETNLSEYMKLRLLQSPSQVIYNLENTVSLYRRCLNLRKRLMDISELAAFFDSIHREALNSSFKILEFKDIEFDDPVTEIWLFCRLGYPLCALFNCLPVKQKLEVNSSVSLENTNVCKASLYRFMLMCKNELGLTDAALFSISEIYKPSTAPLVRALQTIELLLKKYEVSNTTKSSSTPSPSTDDNVPTGTLNSLIASGRRVTAELYETELKYIQDLEYLSNYMVILQQKQILSQDTILSIFTNLNEILDFQRRFLVGLEMNLSLPVEEQRLGALFIALEEGFSVYQVFCTNFPNAQQLIIDNQNQLLKVANLLEPSYELPALLIKPIQRICKYPLLLNQLLKGTPSGYQYEEELKQGMACVVRVANQVNETRRIHENRNAIIELEQRVIDWKGYSLQYFGQLLVWDVVNVCKADIEREYHVYLFEKILLCCKEMSTLKRQARSISMNKKTKRLDSLQLKGRILTSNITTVVPNHHMGSYAIQIFWRGDPQHESFILKLRNEESHKLWMSVLNRLLWKNEHGSPKDIRSAASTPANPVYNRSSSQTSKGYNSSDYDLLRTHSLDENVNSPTSISSPSSKSSPFTKTTSKDTKSATTTDERPSDFIRLNSEESVGTSSLRTSQTTSTIVSNDSSSTASIPSQISRISQVNSLLNDYNYNRQSHITRVYSGTDDGSSVSIFEDTSSSTKQKIFDQPTTNDCDVMRPRQYSYSAGMKSDGSLLPSTKHTSLSSSSTSTSLSVRNTTNVKIRLRLHEVSLVLVVAHDITFDELLAKVEHKIKLCGILKQAVPFRVRLKYVDEDGDFITITSDEDVLMAFETCTFELMDPVHNKGMDTVSLHVVVYF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13PhosphorylationDRKTSSRSLPSYINH
CCCCCCCCCCHHHCC		46.7225720772
559PhosphorylationGSPKDIRSAASTPAN
CCHHHHHHHHCCCCC		28.6424763107
562PhosphorylationKDIRSAASTPANPVY
HHHHHHHCCCCCCCC		34.3424763107
563PhosphorylationDIRSAASTPANPVYN
HHHHHHCCCCCCCCC		22.9925720772
572PhosphorylationANPVYNRSSSQTSKG
CCCCCCCCCCCCCCC		30.6121712547
577PhosphorylationNRSSSQTSKGYNSSD
CCCCCCCCCCCCCHH		19.2221712547
580PhosphorylationSSQTSKGYNSSDYDL
CCCCCCCCCCHHHHH		18.6621712547
582PhosphorylationQTSKGYNSSDYDLLR
CCCCCCCCHHHHHHH		18.9929996109
583PhosphorylationTSKGYNSSDYDLLRT
CCCCCCCHHHHHHHH		36.2328889911
585PhosphorylationKGYNSSDYDLLRTHS
CCCCCHHHHHHHHCC		15.5021712547
590PhosphorylationSDYDLLRTHSLDENV
HHHHHHHHCCCCCCC		18.7824763107
592PhosphorylationYDLLRTHSLDENVNS
HHHHHHCCCCCCCCC		36.5828889911
599PhosphorylationSLDENVNSPTSISSP
CCCCCCCCCCCCCCC		25.8529996109
604PhosphorylationVNSPTSISSPSSKSS
CCCCCCCCCCCCCCC		35.6429996109
605PhosphorylationNSPTSISSPSSKSSP
CCCCCCCCCCCCCCC		27.4229996109
607PhosphorylationPTSISSPSSKSSPFT
CCCCCCCCCCCCCCC		52.9629996109
608PhosphorylationTSISSPSSKSSPFTK
CCCCCCCCCCCCCCC		39.6829996109
639PhosphorylationSDFIRLNSEESVGTS
CCCEECCCCCCCCCC		47.5429996109
642PhosphorylationIRLNSEESVGTSSLR
EECCCCCCCCCCCCC		23.0725720772
664PhosphorylationIVSNDSSSTASIPSQ
EECCCCCCCCCCCHH		31.7625720772
667PhosphorylationNDSSSTASIPSQISR
CCCCCCCCCCHHHHH		34.8125720772
697PhosphorylationQSHITRVYSGTDDGS
CCCEEEEEECCCCCC		9.7025720772
698PhosphorylationSHITRVYSGTDDGSS
CCEEEEEECCCCCCE		32.1525720772
738PhosphorylationVMRPRQYSYSAGMKS
CCCCCEEECCCCCCC		12.3127738172
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SCD1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SCD1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SCD1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GEF1_SCHPOgef1genetic
12972551
CDC42_SCHPOcdc42genetic
12972551
KLP5_SCHPOklp5genetic
14573463
KLP6_SCHPOklp6genetic
14573463
VTC1_SCHPOnrf1genetic
11042180
CDC42_SCHPOcdc42genetic
11042180
RAS_SCHPOras1physical
16754851
SCD2_SCHPOscd2physical
9660817
SCD2_SCHPOscd2physical
12409291
CDC42_SCHPOcdc42physical
12409291
KLP5_SCHPOklp5physical
14573463
KLP6_SCHPOklp6physical
14573463
SCD2_SCHPOscd2physical
10567532
TBB_SCHPOnda3genetic
11063680
TBA1_SCHPOnda2genetic
11063680
RAL2_SCHPOral2genetic
3071741
SCD2_SCHPOscd2genetic
3071741
RAS_SCHPOras1genetic
3071741
CDC42_SCHPOcdc42physical
23615447
SCD2_SCHPOscd2physical
23615447
YH7G_SCHPOSPBC16G5.16physical
26771498
RGA4_SCHPOrga4genetic
26960792
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SCD1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-583, AND MASSSPECTROMETRY.

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