HSP72_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HSP72_SCHPO
• UniProt AC: O59855
• Protein Name: Probable heat shock protein ssa2
• Gene Name: ssa2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 647
• Subcellular Localization: Cytoplasm .
• Protein Sequence: MSKSIGIDLGTTYSCVGHFSNNRVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPHNTIFDAKRLIGRKFDDPEVQSDMKHWPFKVISKDGKPVLQVEYKGETKTFTPEEISSMVLMKMRETAEAYLGGKVTDAVVTVPAYFNDSQRQATKDAGLIAGLNVLRIINEPTAAAIAYGLDRSNQGESNVLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDSRLVNHFIQEFKRKNKKDITGNARAVRRLRTACERAKRTLSSSAQASIEIDSLFEGIDFYTSITRARFEELCADLFRKTMEPVERVLRDSKVDKASVNEIVLVGGSTRIPRVQKLVSDFFNGKEPCKSINPDEAVAYGAAVQAAVLTGDTSEKTQDLLLLDVAPLSMGIETAGGVMTPLIKRNTTIPTKKSEIFSTYSDNQPGVLIQVFEGERARTKDCNLLGKFELSGIPPAPRGVPQIEVTFDVDANGILNVSALEKGTGKTQKITITNDKGRLSKEEIDRMVAEAEKYKAEDEAESGRIQAKNHLESYAYSLRNSLDDPNLKDKVDASDKETVDKAVKETIEWLDSNTTAAKDEFEAKQKELESVANPIMAKIYQAGGAPGGMPGAAPGAAPGAAPGAAPGGDNGPEVEEVD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSKSIGIDL ------CCCCCCEEC	34.80	-
35	Phosphorylation	ANDQGNRTTPSYVAF ECCCCCCCCCCEEEE	47.24	25720772
36	Phosphorylation	NDQGNRTTPSYVAFT CCCCCCCCCCEEEEE	13.65	28889911
147	Phosphorylation	AVVTVPAYFNDSQRQ EEEEEECCCCHHHCH	9.24	24763107
151	Phosphorylation	VPAYFNDSQRQATKD EECCCCHHHCHHHHH	28.50	28889911
339	Phosphorylation	IVLVGGSTRIPRVQK EEEECCCCCCHHHHH	35.57	28889911
383	Phosphorylation	AVLTGDTSEKTQDLL HHHCCCCCHHHHHEE	41.66	27738172
416	Phosphorylation	TPLIKRNTTIPTKKS CHHHCCCCCCCCCHH	30.09	24763107
417	Phosphorylation	PLIKRNTTIPTKKSE HHHCCCCCCCCCHHH	28.63	28889911
420	Phosphorylation	KRNTTIPTKKSEIFS CCCCCCCCCHHHHEE	47.45	25720772
423	Phosphorylation	TTIPTKKSEIFSTYS CCCCCCHHHHEEEEC	37.16	29996109
427	Phosphorylation	TKKSEIFSTYSDNQP CCHHHHEEEECCCCC	31.90	29996109
428	Phosphorylation	KKSEIFSTYSDNQPG CHHHHEEEECCCCCE	19.12	29996109
429	Phosphorylation	KSEIFSTYSDNQPGV HHHHEEEECCCCCEE	16.90	21712547
430	Phosphorylation	SEIFSTYSDNQPGVL HHHEEEECCCCCEEE	30.12	25720772
502	Phosphorylation	KTQKITITNDKGRLS CCEEEEEECCCCCCC	28.81	29996109
509	Phosphorylation	TNDKGRLSKEEIDRM ECCCCCCCHHHHHHH	36.34	28889911
542	Phosphorylation	QAKNHLESYAYSLRN CHHHHHHHHHHHHHH	22.79	21712547
543	Phosphorylation	AKNHLESYAYSLRNS HHHHHHHHHHHHHHC	10.53	21712547
545	Phosphorylation	NHLESYAYSLRNSLD HHHHHHHHHHHHCCC	10.45	21712547
546	Phosphorylation	HLESYAYSLRNSLDD HHHHHHHHHHHCCCC	16.81	28889911
550	Phosphorylation	YAYSLRNSLDDPNLK HHHHHHHCCCCCCHH	27.09	24763107
563	Phosphorylation	LKDKVDASDKETVDK HHHCCCCCCHHHHHH	44.76	21712547
567	Phosphorylation	VDASDKETVDKAVKE CCCCCHHHHHHHHHH	39.48	21712547
581	Phosphorylation	ETIEWLDSNTTAAKD HHHHHHHHCCCHHHH	33.63	29996109
583	Phosphorylation	IEWLDSNTTAAKDEF HHHHHHCCCHHHHHH	23.05	21712547
584	Phosphorylation	EWLDSNTTAAKDEFE HHHHHCCCHHHHHHH	28.94	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HSP72_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HSP72_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HSP72_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of HSP72_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-36; THR-339; THR-417 ANDSER-546, AND MASS SPECTROMETRY.
PubMed: 18257517