EIF3G_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EIF3G_SCHPO
• UniProt AC: P78795
• Protein Name: Eukaryotic translation initiation factor 3 subunit G {ECO:0000255|HAMAP-Rule:MF_03006}
• Gene Name: tif35
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 282
• Subcellular Localization: Cytoplasm .
• Protein Description: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA..
• Protein Sequence: MSSSKSLDWADDEDYGTGLPSIQTFDNPDGTKTMIEFRIDDNGKKVKVTRVIRKTVITERVQHAVAERKKWKKFGKEAGKNSGVDARTTSVGENVQLRLQLGWTTTKEEEQDEAALAAAKVKAKGSSVVRCRACKGNHFTAQCPYKSIIGPVDEPPLDASPVSSRASGALGEKGRYIAPHLRAGSGRESGDSMFKRERDDSATLRVTNLSDDTREEELRDLFRRFGGIQRVYLAKDKETGRAKGFAFVSYYDRDCAIKARDRLDGYGWNNLILRCEFSKPRD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MSSSKSLDWADDE --CCCCCCCCCCCCC	33.24	24763107
90	Phosphorylation	GVDARTTSVGENVQL CCCCCCCCCCCCEEE	27.75	28889911
147	Phosphorylation	TAQCPYKSIIGPVDE EEECCCCCEECCCCC	17.37	29996109
160	Phosphorylation	DEPPLDASPVSSRAS CCCCCCCCCCCCHHC	26.04	28889911
163	Phosphorylation	PLDASPVSSRASGAL CCCCCCCCCHHCCCC	19.93	21712547
164	Phosphorylation	LDASPVSSRASGALG CCCCCCCCHHCCCCC	31.90	28889911
167	Phosphorylation	SPVSSRASGALGEKG CCCCCHHCCCCCCCC	24.40	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EIF3G_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EIF3G_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EIF3G_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EIF3A_SCHPO	tif32	physical	11134033
EIF3I_SCHPO	sum1	physical	11134033
EIF3E_SCHPO	int6	physical	11134033

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160 AND SER-164, ANDMASS SPECTROMETRY.
PubMed: 18257517