| UniProt ID | VPS27_SCHPO | |
|---|---|---|
| UniProt AC | O13821 | |
| Protein Name | Vacuolar protein sorting-associated protein 27 | |
| Gene Name | sst4 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 610 | |
| Subcellular Localization |
Endosome membrane Peripheral membrane protein Cytoplasmic side. Cytoplasm . |
|
| Protein Description | Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.. | |
| Protein Sequence | MSRWWNSNSQFASDIEKATSETLPAGSEEISLYLEISDQIRSKSVDPKFAMRILKSRIDHSNPNVQIMALKLTDTCVKNGGSGFLLEIASREFMDNLVSILRSPAGIDEDVKMVILRYIQSWALAVPDTNSPLSYIIHVYQNLKDGDYEFPEPSQNITSKFLDTETPPDWTDSEVCLRCRTPFTFTNRKHHCRNCGGVFCNQCSSKTLSLPHLGINQPVRVCDSCYSLRTKPKGSKSRARNERKFHAKTRKTPSKPVTNNEDEDIKRAIELSLKEMPQSREPPSYERPSEANVVISQDQHLTEDEDEELKRAIAISLEEAQKSSQKDDNVTAPNNMNISYPSVPAHTVSTDIRSSPFSGRPSDNPSTLISTADADNITLYATLVQKLKKLPPGSIFTEYQLQELHENMGVMRTRMMRSLGETMSKYNGLIQALQKLQTCMRLNDALIEQRLSSTYAHHYIDSSMDSNRSIEPEPDVISTVRNSSTIPQASSSSVPKIVVDSSPVTENPPSHSDVMGQKDTISSYYSTDTDVSANVMGNRHDEVVFSDTASGEKNTKLNIDESTNYYNTDSIDKVGEPFDEISSGYDDLMNGNDKQGNDIPEVQEASLIEL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 252 | Phosphorylation | FHAKTRKTPSKPVTN HCCCCCCCCCCCCCC | 29.51 | 21712547 | |
| 284 | Phosphorylation | PQSREPPSYERPSEA CCCCCCCCCCCCCCC | 50.79 | 29996109 | |
| 289 | Phosphorylation | PPSYERPSEANVVIS CCCCCCCCCCCEEEC | 56.41 | 29996109 | |
| 296 | Phosphorylation | SEANVVISQDQHLTE CCCCEEECCCCCCCC | 18.98 | 29996109 | |
| 302 | Phosphorylation | ISQDQHLTEDEDEEL ECCCCCCCCCCCHHH | 38.99 | 21712547 | |
| 490 | Phosphorylation | SSTIPQASSSSVPKI CCCCCCCCCCCCCEE | 26.04 | 29996109 | |
| 492 | Phosphorylation | TIPQASSSSVPKIVV CCCCCCCCCCCEEEE | 32.62 | 25720772 | |
| 493 | Phosphorylation | IPQASSSSVPKIVVD CCCCCCCCCCEEEEC | 44.37 | 28889911 | |
| 501 | Phosphorylation | VPKIVVDSSPVTENP CCEEEECCCCCCCCC | 25.57 | 28889911 | |
| 502 | Phosphorylation | PKIVVDSSPVTENPP CEEEECCCCCCCCCC | 20.94 | 21712547 | |
| 505 | Phosphorylation | VVDSSPVTENPPSHS EECCCCCCCCCCCHH | 33.17 | 21712547 | |
| 512 | Phosphorylation | TENPPSHSDVMGQKD CCCCCCHHHHCCCCC | 35.92 | 28889911 | |
| 546 | Phosphorylation | RHDEVVFSDTASGEK CCCEEEEECCCCCCC | 23.57 | 29996109 | |
| 548 | Phosphorylation | DEVVFSDTASGEKNT CEEEEECCCCCCCCC | 22.86 | 29996109 | |
| 550 | Phosphorylation | VVFSDTASGEKNTKL EEEECCCCCCCCCEE | 49.96 | 25720772 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VPS27_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VPS27_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VPS27_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of VPS27_SCHPO !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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