dbPTM

THI6_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	THI6_SCHPO
UniProt AC	P40386
Protein Name	Probable thiamine biosynthetic bifunctional enzyme
Gene Name	thi4
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	518
Subcellular Localization
Protein Description	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)..
Protein Sequence	MKRQIDYSLYLVTSSSLIAPGSTIERQVEEGILGGVTLVQHREKDISTKCFVERAKRLSEICKKYDVPFLINDRIDVALAVGADGVHIGQDDMDCALARKILGDDAIIGVSTNNIEEIEKAAADGADYVGIGSIYETNTKDVKDRLIGITGLRKILEHVSKMHCQLGTVAIAGLNSSNIQRVIYLSEANGKRIDGIALVSAIMCSITPRETAKELRNLIATPPCFAQARSSLTTPKDLLNQIPAALQKLKDFTPLIHHLTNAVAKNFSANVTLAAYGSPTMGESYDEVADFAKAPGALVLNIGILENTKTYIHAAQVNNDLARPVILDPVAVGATTARSKVINTLLNYAYYDIIKGNEGEIMNLAGEQGLMRGVDSISQHTLAARITAVHRLAVERRCVVAMSGAVDVISDGNSTYVIKNGNPLLGQITASGCSLGSVMGVTASICQNDKLLAAITATLLYNIASELAVEAKNSCGDLLVQGPGTFIPIFVDKLHQLINETIKGNVDWIERAKLEKAE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
221	Phosphorylation	ELRNLIATPPCFAQA HHHHHCCCCHHHHHH	22.29	25720772
230	Phosphorylation	PCFAQARSSLTTPKD HHHHHHHHCCCCHHH	32.49	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of THI6_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of THI6_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of THI6_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ELP5_SCHPO	elp5	genetic	18818364
HPC2_SCHPO	hip4	genetic	18818364
THI6_SCHPO	thi4	physical	26771498
YF75_SCHPO	spa2	physical	26771498
IMA2_SCHPO	imp1	physical	26771498

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of THI6_SCHPO

Related Literatures of Post-Translational Modification