RGA2_SCHPO - dbPTM
RGA2_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RGA2_SCHPO
UniProt AC Q10164
Protein Name Probable Rho-type GTPase-activating protein 2
Gene Name rga2
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1275
Subcellular Localization Nucleus .
Protein Description GTPase-activating protein for Rho-type proteins..
Protein Sequence MVKMDVVRTTGFFLRSEPTTCRITTFAYSAEIIYFHAETTFLFEKIMKEGNELEKYSKIELNSEIWEDEEEEDNSGIVSQNERLMKLVNKQREIIYELHKDLEKVKKDNTSLRMRLSKYESTDSFPSSQPSRANSPQSDSYSSPYEKGKLFPKISLKSSKDVPTASAHISSSDHEKSSSVSLSALNNYNKTTDIKARSLDRLSDMTRPKLLLNTKRSHRSSEEPGASSPVTSPILKDSQKERIQALRNKAIKTYSVSTESAERIDSIRSDNLSPLSLNTSSFRRPITKPTPFNSDSNISIDPKDNNSNKQDHFAEIEDELRQQFLDIKVGRANASSPRRKSISIVKPHGISSPKHSTNNLSSKSGKFHSDFRVVSENVLLQARSETNSPIIENKEANNFLAPTSNVPAYSTPARPTESPPPPPISSSSTTPRPDDKPSLPPRGLSEDNDSLSLQKTGSSDTRRSSFSTLKIPDSDICFTRRRSDSNRTWTVIDPHHSQSFDNDILAEIPTSKLDNSSQKSPGKLSSKGLLNSFSPISPFSKSKSHNHHPSSQVEKSTSNSKGSMLPLDTLYNNKLSFRLDESLVRYLRFELMKTSLASLSPDFDCIGLQFVVGVSASSHLASQWKDEVWSFTRSIGECRSFATSFVLDIGAPPFPTLDWFTNDSSVIQNELLRRSVDTYFRYIFQTDLKLEQRIKLLEFLSSDTLREYLHDVFFLPPEHAQKEGVLLKYIENSGLVSRYFYLKDNILYFAENRNSPVLGTIHLKDAQVNRYNANLPIFSIIDPPHEFLTGENYQSAFVIQEKQTETRTGTATVHVLLARDVEDQKSWLRAILRQVPGSTSPLNASPFSVLSSDFPGSSRYRDQSSPIRFYGKADSRPVSQEAILSQDISSSPSPVLPPSENVASYADDSLVSNLTMSPKLRDSMEQVPLENHREFEISDRVSELSFDSSTGSVLEIADTRRNQDAPEKHVPVIEIQSSRPSLEKTDQSTPVELLIDSHSQNSQNEEKRSRMKFWAFPHHKAENYEQISDTNIPVIETNVMLSPSSTTSAEPLQKHIVRKSGIFGLPLNEAVNISTQFNDSGLPIVVYRCIEYLESCRAEKEEGIYRLSGSASTIKHLKEQFNEGVDYDLLSSDEEFDVHVIAGLLKLYLRNLPTNLLDTSMHKLFELLPNVPNDSAALGELCDVISKLPPENFALLDSLLHHLRRIIAFEKVNKMNIRNVCIVFSPTLNIPSDIFMMLILNYDHIFTDISRQTNGAQNESDSDVSDDNGEDNEFF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
131PhosphorylationSFPSSQPSRANSPQS
CCCCCCCCCCCCCCC		36.0725720772
135PhosphorylationSQPSRANSPQSDSYS
CCCCCCCCCCCCCCC		24.2728889911
138PhosphorylationSRANSPQSDSYSSPY
CCCCCCCCCCCCCCC		31.7225720772
141PhosphorylationNSPQSDSYSSPYEKG
CCCCCCCCCCCCCCC		20.4025720772
179PhosphorylationSDHEKSSSVSLSALN
CCCCCCCCCCHHHHH		23.8624763107
181PhosphorylationHEKSSSVSLSALNNY
CCCCCCCCHHHHHCC		20.6828889911
188PhosphorylationSLSALNNYNKTTDIK
CHHHHHCCCCCCCCC		19.5725720772
227PhosphorylationSSEEPGASSPVTSPI
CCCCCCCCCCCCCCC		40.8824763107
228PhosphorylationSEEPGASSPVTSPIL
CCCCCCCCCCCCCCC		23.9028889911
231PhosphorylationPGASSPVTSPILKDS
CCCCCCCCCCCCCCC		31.9724763107
232PhosphorylationGASSPVTSPILKDSQ
CCCCCCCCCCCCCCH		15.3528889911
238PhosphorylationTSPILKDSQKERIQA
CCCCCCCCHHHHHHH		41.3825720772
269PhosphorylationERIDSIRSDNLSPLS
HHHHHHCCCCCCCCC		29.2229996109
273PhosphorylationSIRSDNLSPLSLNTS
HHCCCCCCCCCCCCC		30.0128889911
276PhosphorylationSDNLSPLSLNTSSFR
CCCCCCCCCCCCCCC		23.9825720772
294PhosphorylationTKPTPFNSDSNISID
CCCCCCCCCCCEEEC		42.6825720772
341PhosphorylationASSPRRKSISIVKPH
CCCCCCCCEEEECCC		21.5424763107
343PhosphorylationSPRRKSISIVKPHGI
CCCCCCEEEECCCCC		28.5521712547
351PhosphorylationIVKPHGISSPKHSTN
EECCCCCCCCCCCCC		45.2225720772
352PhosphorylationVKPHGISSPKHSTNN
ECCCCCCCCCCCCCC		35.7324763107
356PhosphorylationGISSPKHSTNNLSSK
CCCCCCCCCCCCCCC		38.6721712547
357PhosphorylationISSPKHSTNNLSSKS
CCCCCCCCCCCCCCC		28.0421712547
375PhosphorylationHSDFRVVSENVLLQA
CCCCEEEEHHHEEEE		22.1621712547
384PhosphorylationNVLLQARSETNSPII
HHEEEECCCCCCCCC		52.3621712547
386PhosphorylationLLQARSETNSPIIEN
EEEECCCCCCCCCCC		42.0925720772
388PhosphorylationQARSETNSPIIENKE
EECCCCCCCCCCCCC		25.5428889911
411PhosphorylationSNVPAYSTPARPTES
CCCCCCCCCCCCCCC		14.3227738172
445PhosphorylationSLPPRGLSEDNDSLS
CCCCCCCCCCCCCCC		45.8125720772
450PhosphorylationGLSEDNDSLSLQKTG
CCCCCCCCCCCEECC		26.5525720772
452PhosphorylationSEDNDSLSLQKTGSS
CCCCCCCCCEECCCC		32.4825720772
456PhosphorylationDSLSLQKTGSSDTRR
CCCCCEECCCCCCCC		29.3625720772
458PhosphorylationLSLQKTGSSDTRRSS
CCCEECCCCCCCCCC		30.2125720772
459PhosphorylationSLQKTGSSDTRRSSF
CCEECCCCCCCCCCC		44.3325720772
465PhosphorylationSSDTRRSSFSTLKIP
CCCCCCCCCEEEECC		22.7729996109
467PhosphorylationDTRRSSFSTLKIPDS
CCCCCCCEEEECCCC		34.4729996109
517PhosphorylationTSKLDNSSQKSPGKL
HHHCCCCCCCCCCCC		48.1325720772
520PhosphorylationLDNSSQKSPGKLSSK
CCCCCCCCCCCCCCC		31.1121712547
525PhosphorylationQKSPGKLSSKGLLNS
CCCCCCCCCCCCCCC		33.2321712547
532PhosphorylationSSKGLLNSFSPISPF
CCCCCCCCCCCCCCC		27.3725720772
534PhosphorylationKGLLNSFSPISPFSK
CCCCCCCCCCCCCCC		22.5725720772
537PhosphorylationLNSFSPISPFSKSKS
CCCCCCCCCCCCCCC		24.2324763107
540PhosphorylationFSPISPFSKSKSHNH
CCCCCCCCCCCCCCC		39.1325720772
838PhosphorylationILRQVPGSTSPLNAS
HHHHCCCCCCCCCCC		21.4625720772
839PhosphorylationLRQVPGSTSPLNASP
HHHCCCCCCCCCCCC		40.0325720772
840PhosphorylationRQVPGSTSPLNASPF
HHCCCCCCCCCCCCC		29.1425720772
845PhosphorylationSTSPLNASPFSVLSS
CCCCCCCCCCEEECC		25.9625720772
848PhosphorylationPLNASPFSVLSSDFP
CCCCCCCEEECCCCC		26.0727738172
864PhosphorylationSSRYRDQSSPIRFYG
CCCCCCCCCCEEEEC		42.2329996109
865PhosphorylationSRYRDQSSPIRFYGK
CCCCCCCCCEEEECC		20.7929996109
870PhosphorylationQSSPIRFYGKADSRP
CCCCEEEECCCCCCC		14.1029996109
923PhosphorylationMSPKLRDSMEQVPLE
CCHHHHHCHHHCCCC		20.1329996109
977PhosphorylationVPVIEIQSSRPSLEK
CCEEEEECCCCCCCC		33.6924763107
978PhosphorylationPVIEIQSSRPSLEKT
CEEEEECCCCCCCCC		31.6625720772
981PhosphorylationEIQSSRPSLEKTDQS
EEECCCCCCCCCCCC		48.3124763107
997PhosphorylationPVELLIDSHSQNSQN
CHHHHCCCCCCCCCC		20.3221712547
999PhosphorylationELLIDSHSQNSQNEE
HHHCCCCCCCCCCHH		34.7025720772
1002PhosphorylationIDSHSQNSQNEEKRS
CCCCCCCCCCHHHHH		27.0925720772
1108PhosphorylationEEGIYRLSGSASTIK
HCCCEEECCCHHHHH		23.0028889911
1110PhosphorylationGIYRLSGSASTIKHL
CCEEECCCHHHHHHH		18.7028889911
1113PhosphorylationRLSGSASTIKHLKEQ
EECCCHHHHHHHHHH		33.4928889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RGA2_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RGA2_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RGA2_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RHO2_SCHPOrho2physical
18793338
CDC42_SCHPOcdc42physical
18793338
MKH1_SCHPOmkh1genetic
18793338
RHO2_SCHPOrho2genetic
18793338
RGA7_SCHPOrga7genetic
20164182
COX19_SCHPOSPCC1672.04cgenetic
22681890
ASL1_SCHPOasl1genetic
22681890
CCH1_SCHPOcch1genetic
22681890
CSN3_SCHPOcsn3genetic
22681890
NU132_SCHPOnup132genetic
22681890
PPK33_SCHPOppk33genetic
22681890
GMS1_SCHPOgms1genetic
22681890
ERI1_SCHPOeri1genetic
22681890
ENOPH_SCHPOSPAC644.08genetic
22681890
ARP6_SCHPOarp6genetic
22681890
PDX1_SCHPOsnz1genetic
22681890
RNC1_SCHPOrnc1genetic
22681890
ERG28_SCHPOerg28genetic
22681890
CTBL1_SCHPOSPAC1952.06cgenetic
22681890
RS3_SCHPOrps3genetic
22681890
YAA7_SCHPOime4genetic
22681890
STT4_SCHPOstt4genetic
22681890
MUG33_SCHPOmug33genetic
22681890
NEM1_SCHPOnem1genetic
22681890
YLO2_SCHPOtma23genetic
22681890
YD72_SCHPOSPAC32A11.02cgenetic
22681890
YE08_SCHPOSPAC17H9.08genetic
22681890
PPR2_SCHPOppr2genetic
22681890
YGWH_SCHPOgmh4genetic
22681890
MU113_SCHPOmug113genetic
22681890
MUG80_SCHPOmug80genetic
22681890
YL85_SCHPOdeg1genetic
22681890
YIV5_SCHPOSPAC144.05genetic
22681890
HMT2_SCHPOhmt2genetic
22681890
MFH2_SCHPOfml2genetic
22681890
FSC1_SCHPOfsc1genetic
22681890
YCKC_SCHPOSPCC1450.12genetic
22681890
YFM8_SCHPOSPAC222.08cgenetic
22681890
ABC2_SCHPOabc2genetic
22681890
CYSK_SCHPOcys11genetic
22681890
YII1_SCHPOSPAC139.01cgenetic
22681890
YA7B_SCHPOSPAC24H6.11cgenetic
22681890
YOW5_SCHPOSPBC1861.05genetic
22681890
SERA_SCHPOser3genetic
22681890
OMH5_SCHPOomh5genetic
22681890
MCP2_SCHPOmcp2genetic
22681890
PPID_SCHPOwis2genetic
22681890
YDW7_SCHPOSPAC23C11.07genetic
22681890
SUM2_SCHPOsum2genetic
22681890
NHP6_SCHPOnhp6genetic
22681890
YFH2_SCHPOSPAC23A1.02cgenetic
22681890
TFS2_SCHPOtfs1genetic
22681890
YI4C_SCHPOSPBC1348.12genetic
22681890
SPN2_SCHPOspn2genetic
22681890
KLP6_SCHPOklp6genetic
22681890
EHS1_SCHPOyam8genetic
22681890
YJE6_SCHPOSPCC1682.06genetic
22681890
PMP20_SCHPOpmp20genetic
22681890
MET8_SCHPOSPAC4D7.06cgenetic
22681890
SEC74_SCHPOsec74genetic
22681890
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RGA2_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-388, AND MASSSPECTROMETRY.

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