dbPTM

SERA_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SERA_SCHPO
UniProt AC	P87228
Protein Name	Putative D-3-phosphoglycerate dehydrogenase
Gene Name	SPCC364.07, SPCC4G3.01
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	466
Subcellular Localization
Protein Description	Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate..
Protein Sequence	MDIKGGRRGNVEDSLNKLSLSPPDNNSSFLSNHFQVRKSYSQAPARTLKPFASEDIKILLLENVNQSALSNLKDEGYQVEFLKTSMSEDDLVEKIKGVHAIGIRSKTRLTRRVLEAADSLIVIGCFCIGTNQVDLDFAAERGIAVFNSPYANSRSVAELVIGYIISLARQVGDRSLELHRGEWNKVSSGCWEIRGKTLGIIGYGHIGSQLSVLAEAMGLHVVYYDILPIMPLGSAKQLSSLPELLHRADFVSLHVPASPETKNMISSKEFAAMKEGSYLINASRGTVVDIPALVDASKSGKIAGAAIDVYPSEPAGNGKDKFVDSLNSWTSELTHCKNIILTPHIGGSTEEAQYNIGIEVSEALTRYINEGNSIGAVNFPEVSLRSLTEADRNAARVLFVHRNVPGVLRQVNELFIDHNIKSQFSDSRGDIAYLVADISDCTPGSLEALHQKLESLPCKINTRLLY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	RRGNVEDSLNKLSLS CCCCHHHHHHHCCCC	21.97	24763107
19	Phosphorylation	EDSLNKLSLSPPDNN HHHHHHCCCCCCCCC	28.54	21712547
21	Phosphorylation	SLNKLSLSPPDNNSS HHHHCCCCCCCCCCC	30.89	24763107
27	Phosphorylation	LSPPDNNSSFLSNHF CCCCCCCCCHHHHHH	28.81	29996109
28	Phosphorylation	SPPDNNSSFLSNHFQ CCCCCCCCHHHHHHH	32.12	21712547
31	Phosphorylation	DNNSSFLSNHFQVRK CCCCCHHHHHHHHCC	26.67	21712547
39	Phosphorylation	NHFQVRKSYSQAPAR HHHHHCCCCCCCCCC	21.32	21712547
40	Phosphorylation	HFQVRKSYSQAPART HHHHCCCCCCCCCCC	14.08	25720772
41	Phosphorylation	FQVRKSYSQAPARTL HHHCCCCCCCCCCCC	27.27	24763107
47	Phosphorylation	YSQAPARTLKPFASE CCCCCCCCCCCCCCC	41.04	21712547
87	Phosphorylation	EFLKTSMSEDDLVEK EEEECCCCHHHHHHH	37.33	28889911
188	Phosphorylation	GEWNKVSSGCWEIRG CCCCCCCCCCEEECC	40.74	28889911
258	Phosphorylation	VSLHVPASPETKNMI EEEECCCCHHHCCCC	19.73	28889911
261	Phosphorylation	HVPASPETKNMISSK ECCCCHHHCCCCCHH	30.97	29996109
286	Phosphorylation	LINASRGTVVDIPAL EEECCCCEEEEHHHE	19.08	29996109
297	Phosphorylation	IPALVDASKSGKIAG HHHEEEHHHCCCCCC	23.92	28889911
445	Phosphorylation	ISDCTPGSLEALHQK HHHCCCCCHHHHHHH	25.00	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SERA_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SERA_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SERA_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SERA_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SERA_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87 AND SER-258, AND MASSSPECTROMETRY.	18257517 [Abstract]