ABC2_SCHPO - dbPTM
ABC2_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ABC2_SCHPO
UniProt AC Q10185
Protein Name ATP-binding cassette transporter abc2
Gene Name abc2
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1478
Subcellular Localization Vacuole membrane
Multi-pass membrane protein .
Protein Description Involved in vacuolar sequestration of glutathione S-conjugates. Together with abc4, required for accumulation of a red pigment (ade pigment) in the vacuole of a mutant affected in the adenine biosynthetic pathway..
Protein Sequence MVLEQDLDPFVGGNWMNSAYKGFTFLSATWLAPNIYLLISGCLQYFYEVRKRSHYFHFRRFWTIWLKSLVIMVLLFTHIYDCYKTNESVWNVLSIITYFLALFLHVVEQPTLRIPMASLLMFWLFKFLASALVLLLRPNYTMFPMLNVVPSITFFCSLVCLLAEIYVPPANRVWYPDDAAELEETGLRPSRFTYANIFSRISFGWLSPLMKFGYRNYLTESDAWSLPPAERSSNLTIVFEKNWISHAKKKKSSLYMWGVLFLNHWKLTVVIIVLKLVQDVVAFIQPNLIRKIVIFVSSYSSEHPQPPQVGFSLAIAMFLTNVVQTALLQQYFQLGMVLGMRWRSELITAIYRKSLRLSSAARQSRSVGDIVNYMSVDTQKVCDLTMFLFVIVSGPFQIVLALTNLYHLVGYGALSGAFVTFLLFPCNVVIASIFKRFQNRQMKNKDARSQFMTEIINNIRSIKLYAWENIFLQKLLQLRNTRELRMLKKIGIVNTIGNFTWLFAPILVSAATFGTFIVLYGKTRVLSVDIVFACLSLFNLLQFPLTMLPIVVSSVLEASVAISRIYGFLTAGELDSNAVQRYPANKEPSGVCLEIKKGTFSWSGPGQNAAEPTLRDIDFVARRGELCCIVGKVGMGKSSLLEACLGNMQKHSGSVFRCGSIAYAAQQPWILNATIQENILFGLELDPEFYEKTIRACCLLRDFEILADGDQTEVGEKGISLSGGQKARISLARAVYSRSDIYLLDDILSAVDQHVNRDLVRNLLGSKGLLRSRCVILSTNSLTVLKEASMIYMLRNGKIIESGSFTQLSSSPDSQLFQLLSEFSKKDTASSTGADTPLSRSQSVITSSTDVTSSASRSSDTVSNYPKATIKGTGRIRKRLTDEDNVKATGQAAEKMERGKVKWKVYWTYFKACSLFLIFLYFLFIIGGIGMNVGTNVWLKHWSEVNTQLGYNPKPYFYLGIYTLFGLLSCALISLSSLTITVFCAIKSCRYLHDSMVKAVLRAPMSFFETTPTGRILNRFSSDVYRVDEVISRVFMFFFRNLFQIVFVLAVICYSSPMFMILIVPLFFLYRYNQVYYTQTSRELKRLDSVTRSPLYAHFQESLGGLSTIRAYDMEDTFISENDIRVDTNHRIWFLYFSSNRWQAIRVEAIGALVVFSSAFFGVLSAVRGNPNSGLVGLSLSYAVQITQSLTFVVRQSVDVETNIVSVERMLEYIGLPSEAPSIIPDHRPPEGWPSHGAIKFDHYSVRYRENLPLVLNDISVNIKPQEKIGIVGRTGAGKSTLTLALFRLIEPTSGDIQLDDINITSIGLHDLRSRLAIIPQENQAFEGTIRENLDPNANATDEEIWHALEAASLKQFIQTLDGGLYSRVTEGGANLSSGQRQLMCLTRALLTPTRVLLLDEATAAVDVETDAIVQRTIRERFNDRTILTIAHRINTVMDSNRILVLDHGKVVEFDSTKKLLENKASLFYSLAKESGLI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
86N-linked_GlycosylationIYDCYKTNESVWNVL
HHHHHHCCHHHHHHH		35.08-
139N-linked_GlycosylationLVLLLRPNYTMFPML
HHHHHCCCCCCCCCC		38.17-
232PhosphorylationSLPPAERSSNLTIVF
CCCCCCCCCCEEEEE		18.3225720772
233PhosphorylationLPPAERSSNLTIVFE
CCCCCCCCCEEEEEE		41.9225720772
449PhosphorylationMKNKDARSQFMTEII
CCCHHHHHHHHHHHH		29.5025720772
778PhosphorylationRSRCVILSTNSLTVL
HHCEEEEECCCEEHH		17.8925720772
779PhosphorylationSRCVILSTNSLTVLK
HCEEEEECCCEEHHH		25.9425720772
783PhosphorylationILSTNSLTVLKEASM
EEECCCEEHHHHHHH		24.5025720772
828PhosphorylationSEFSKKDTASSTGAD
HHHCCCCCCCCCCCC		37.0025720772
830PhosphorylationFSKKDTASSTGADTP
HCCCCCCCCCCCCCC		30.4429996109
831PhosphorylationSKKDTASSTGADTPL
CCCCCCCCCCCCCCC		28.5329996109
832PhosphorylationKKDTASSTGADTPLS
CCCCCCCCCCCCCCC		33.6229996109
836PhosphorylationASSTGADTPLSRSQS
CCCCCCCCCCCCCCC		26.1228889911
839PhosphorylationTGADTPLSRSQSVIT
CCCCCCCCCCCCEEE		30.9628889911
841PhosphorylationADTPLSRSQSVITSS
CCCCCCCCCCEEECC		24.3529996109
843PhosphorylationTPLSRSQSVITSSTD
CCCCCCCCEEECCCC		19.4128889911
846PhosphorylationSRSQSVITSSTDVTS
CCCCCEEECCCCCCC		17.9225720772
847PhosphorylationRSQSVITSSTDVTSS
CCCCEEECCCCCCCC		21.8125720772
848PhosphorylationSQSVITSSTDVTSSA
CCCEEECCCCCCCCC		21.7025720772
849PhosphorylationQSVITSSTDVTSSAS
CCEEECCCCCCCCCC		33.9725720772
854PhosphorylationSSTDVTSSASRSSDT
CCCCCCCCCCCCCCC		22.3928889911
856PhosphorylationTDVTSSASRSSDTVS
CCCCCCCCCCCCCCC		34.3425720772
858PhosphorylationVTSSASRSSDTVSNY
CCCCCCCCCCCCCCC		30.0325720772
859PhosphorylationTSSASRSSDTVSNYP
CCCCCCCCCCCCCCC		35.8725720772
861PhosphorylationSASRSSDTVSNYPKA
CCCCCCCCCCCCCCE		27.9925720772
863PhosphorylationSRSSDTVSNYPKATI
CCCCCCCCCCCCEEE		32.5128889911
865PhosphorylationSSDTVSNYPKATIKG
CCCCCCCCCCEEECC		9.9025720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ABC2_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ABC2_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ABC2_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ABC4_SCHPOabc4genetic
16849797
HMT1_SCHPOhmt1genetic
20937798
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ABC2_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-839; SER-843 ANDSER-863, AND MASS SPECTROMETRY.

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