ABC4_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ABC4_SCHPO
• UniProt AC: Q9P7V2
• Protein Name: ATP-binding cassette transporter abc4
• Gene Name: abc4 {ECO:0000312|EMBL:CAB66463.1}
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1469
• Subcellular Localization: Vacuole membrane ; Multi-pass membrane protein .
• Protein Description: Involved in detoxification of xenobiotics, and vacuolar sequestration of glutathione S-conjugates. Together with abc2, required for accumulation of a red pigment (ade pigment) in the vacuole of a mutant affected in the adenine biosynthetic pathway..
• Protein Sequence: MENFHHRPFKGGFGVGRVPTSLYYSLSDFSLSAISIFPTHYDQPYLNEAPSWYKYSLESGLVCLYLYLIYRWITRSFTVKQTVGSEFSGLRKAHGILLWLLSILFLGMTAFMFVNDAFPTAFSDPPVKICLLAYSVHLFLLHSLRMIYPRARPTLYHAAVLLNLLLLPPIFHFYSYPFFFVDHPPLSSYSPFLWFYFFITIVGNFIPLFTPRVWYPLFPEDNYQPSAEQVCSMFNFACSYGYLNPLVLTAKRRVVEVDDTPVIPDYDKNKAWTYRFERMKTPSLFITIHKIFWRQILGMGVSSFMVSVCQFLSPIALNRLLKHLESPSSSSVNPLVWIVLLLTGPFLTSLFTQFYLFMSTRYLARSYTTLVQQIYNKVIRSRFVQNKSGDSKVGRSNNLISTDVDDIGEIREFIHIIVRAPVEIAGSIYLLQKLLGWSAYVGLALTVLTCSVPIVLGPLVAKLTLRANRATDSRIELMSELLQSIRITKFFGWELPMLDRVKQRRQVELNRTWKLLLMEICIQVLVESLPVFSMFATFVVFTTIMGQTITPSIAFTSISLFSFIRTQFSWIAYLMRQIVQIFVSIGRVSDFLNDPDEVDPVNTIEDTSQEIGFFNASLTWVSNPSPGDFCLRDLNIVFPRNKLSIVIGPTGSGKSSLISALLGELSLNKGSYNLPRSKGVSYVSQVPWLRNATIRDNILFDYPYIEERYKKVIQACGLLTDLQSFVASDLTEIGEKGVTLSGGQKQRIALARAVYSPTSIVLMDDVFSALDIHTSNWIYKHCFQSSLMENRTVILVTHNVHLFMDSAAFIVTVKNGSAFPVTDKSSPLLFLAEQAASASEAAAPDLAAIPIPNEVDDAEAADEKDGKLVEEEQRVTGDVVFSEIFSYMKHFGSGFYVAAVLLFFVTTQATSILIDLWVAFWTNSSVNSPDVNNNKFLFVYGTMLLAYSLLDFLRTVSYDRGAWWASRKLHDSMLESVFGTFASWFDKTPTGRIVNRFAKDIRSIDMNLSGWLFFSINCFLSVAGGILSVSSAMPIFMIPAVIVCLAGYYFGLLYTRAQVGVKRLISIYTSPIFSLLGESIVGVSVIRAFNRQTIFKQMFSERLDNLVRLQSTSYNLNRWVAVRTDGISGLVGAIAGLIALLQKDLSPGVVGFSLNQAVIFSSSVLLFVRSCNSLQAEMNSYERVLEYSKLPQEPAPTIAGQVPATWPKEGDIVFNHVSVSYSAAGPTILKDVNLHINPSEKVAVVGRTGSGKSTLGLTLLRFTHRISGEIYINGRETQSVNLNALRQRISFIPQDPILFSGTVRSNLDPFDELEDNFLNEALKTSGASSMIMAHTDDQKPIHITLDTHVASEGSNFSQGQKQVLALARAIVRRSKIIILDECTASVDDAMDQKIQKTLREAFGDATMLCIAHRLKTIVDYDKVMVLDKGVLVEYGPPAVLYHNNGHFRRMCDGSGITFLPPETRGSKSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
386	N-linked_Glycosylation	IRSRFVQNKSGDSKV HHHHHCCCCCCCCCC	34.85	-
510	N-linked_Glycosylation	QRRQVELNRTWKLLL HHHHHHHHHHHHHHH	26.32	-
615	N-linked_Glycosylation	SQEIGFFNASLTWVS CHHCCEEEEEEEEEC	26.76	-
691	N-linked_Glycosylation	SQVPWLRNATIRDNI HCCCCCCCCCCCCCC	38.99	-
790	N-linked_Glycosylation	FQSSLMENRTVILVT HHHHHCCCCEEEEEE	30.84	-
815	N-linked_Glycosylation	AFIVTVKNGSAFPVT EEEEEEECCCEECCC	45.36	-
923	N-linked_Glycosylation	LWVAFWTNSSVNSPD HHHHHHCCCCCCCCC	23.92	-
1007	N-linked_Glycosylation	DIRSIDMNLSGWLFF HHHHCCCCCCHHHHH	27.57	-
1355	N-linked_Glycosylation	HVASEGSNFSQGQKQ CCCCCCCCCCHHHHH	51.99	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ABC4_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ABC4_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ABC4_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of ABC4_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.