dbPTM

DOHH_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DOHH_SCHPO
UniProt AC	Q9P6K9
Protein Name	Deoxyhypusine hydroxylase {ECO:0000255\|HAMAP-Rule:MF_03101}
Gene Name	lia1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	318
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor..
Protein Sequence	MSSEPVPQAVIDELERVLVNLDKSNPLSFRYRALFSLNALAKKGDKRAVDAIYKAFIDDSELLKHEMAYVMGQSGQQYAVQPLINIVNDLDQQVMVRHEAAEALGALGFTESLPVLEKYYKEDPLAPIRETCELAIARIQWKNGLDKNNEKITPSMYDSVVDPAPPMPDHEQDVKSEVAKLRSEIVDQNLPLFYRYRVMFRLRNIGNEEAVLALTDGFKDPSPLFRHEIAFVFGQMIAPASVPALIKVLENTEEVPMVRHEAAEALGGIANDECLPVLKKFSKDDVRVVAESCIVALDMIEYEKSGDMEYAYIPKVSA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of DOHH_SCHPO !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DOHH_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DOHH_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DOHH_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
TBA2_SCHPO	atb2	genetic	14767070

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DOHH_SCHPO

Related Literatures of Post-Translational Modification