dbPTM

IST3_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IST3_SCHPO
UniProt AC	O94290
Protein Name	U2 snRNP component ist3
Gene Name	cwf29
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	217
Subcellular Localization	Nucleus .
Protein Description	Required for pre-mRNA splicing and spliceosome assembly..
Protein Sequence	MNSIRQIERLNEQELDKPFSSSWHQDYSDSAYIYIGNLDFDLNEDDILCVFSEFGEPVDINLVRDKETGKSKGFAFLKYEDQRSTVLAVDNMTNVKLLDRLVRVDHVASYKVPQKEKEPANLVPLGESGSSLSVSTINTSNLPDHDYKTIIQNEVEQTLSPKDEKDLLDPMRDYIHREKRRKLKHESSDRSDKSDSNRHSRHHRRHSRSRRHRDLDG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
158	Phosphorylation	IQNEVEQTLSPKDEK HHHHHHHHCCCCCHH	18.72	21712547
160	Phosphorylation	NEVEQTLSPKDEKDL HHHHHHCCCCCHHHH	33.04	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IST3_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IST3_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IST3_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PYP1_SCHPO	pyp1	genetic	22681890
YO48_SCHPO	SPBC36B7.08c	genetic	22681890
ATP14_SCHPO	atp14	genetic	22681890

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IST3_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160, AND MASSSPECTROMETRY.	18257517 [Abstract]