PAF1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAF1_SCHPO
• UniProt AC: Q9US06
• Protein Name: RNA polymerase II-associated protein 1 homolog
• Gene Name: SPAC664.03
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 456
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Sequence: MENRRQDYILRVRYHNPLPPPPFPPKLINIPNPVKQYALPNFVSTLVQEKKIPIENDIELGMPLDLAGITGFFEGDTSWMHSDLSSVNLDPIDRSLLKVAGGSGSTHLEVPFLRRTEYISSEVARAASNRGNLRLTASTSKALAEQRGRSLREVPKQLEAINESFDVVQQPLEQLKHPTKPDLKPVSAWNLLPNTSMAGIQHLMLRVADDLSERSHSYSSLVNLQEGHNLTKRHEVALFMPSSAEGEEFLSYYLPSEETAEEIQAKVNDASADVHEPFVYNHFRNFDASMHVNSTGLEDLCLTFHTDKDHPEANQVLYTPIYARSTLKRRHVRAPVSLDAVDGIELSLRDLNDEESLQLKRARYDTFGLGNIKDLEEEEEKLRSVEGSLNEELSEEEKPAESREQLESAEQTNGVKPETQAQNMSASESQANSPAPPVEEGNTQPSPVEQLQNEED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
217	Phosphorylation	DLSERSHSYSSLVNL HHHHCCCCHHHHCCH	28.14	25720772
218	Phosphorylation	LSERSHSYSSLVNLQ HHHCCCCHHHHCCHH	9.24	25720772
220	Phosphorylation	ERSHSYSSLVNLQEG HCCCCHHHHCCHHHC	28.27	25720772
384	Phosphorylation	EEEEKLRSVEGSLNE HHHHHHHHHHCHHCH	34.65	19547744
388	Phosphorylation	KLRSVEGSLNEELSE HHHHHHCHHCHHHCC	17.95	28889911
394	Phosphorylation	GSLNEELSEEEKPAE CHHCHHHCCCCCCHH	46.36	28889911
402	Phosphorylation	EEEKPAESREQLESA CCCCCHHHHHHHHHH	43.13	29996109
412	Phosphorylation	QLESAEQTNGVKPET HHHHHHHHCCCCHHH	25.99	27738172
429	Phosphorylation	QNMSASESQANSPAP HHCCCCHHHCCCCCC	31.90	27738172
433	Phosphorylation	ASESQANSPAPPVEE CCHHHCCCCCCCCCC	26.00	27738172
443	Phosphorylation	PPVEEGNTQPSPVEQ CCCCCCCCCCCHHHH	53.35	27738172
446	Phosphorylation	EEGNTQPSPVEQLQN CCCCCCCCHHHHHHC	31.59	27738172

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PAF1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAF1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAF1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TPR1_SCHPO	tpr1	physical	24385927
YOH8_SCHPO	leo1	physical	24385927
CDC73_SCHPO	cdc73	physical	24385927

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-388, AND MASSSPECTROMETRY.
PubMed: 18257517