TPR1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPR1_SCHPO
• UniProt AC: O42668
• Protein Name: Tetratricopeptide repeat protein 1
• Gene Name: tpr1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1039
• Protein Description: Involved in promoting potassiumm ion uptake..
• Protein Sequence: MEGFTLETHASRIIEVPLLGQEDQSVEIDCSSLPSDATELCEILVNEQAPREFWTKFAHEYYIRGLREQAILILKSGLETLKDSESLCILNANIAAIYLSMAREAMLKKDTDLRDEQLRNVRTYLEAANNIDSKSEINVLLHGIYRILLNPTDKESLENAARCFDFVLQKSGGNILGFLGKARILYAKGNYRSALKLYQRALVSNPQFKPDPRIGIGLCFWNLDMKTDALSAWTRVQQLDPKNTVVDTYIGLYYYDLAFQNVNNDSFVQNYGKALQHIQRAFKTRNNDPVASSILERYVYSKKNYEGCIKLAENVIQNSFSSSLIADGYYWMGRAYHQMGNNEKAMASYQKAKAADDRHLLSSVGIGQIQILQNDLTSAKLTFERIAEQNQSCFEALVVLGCLHASDSKPDLTKARMLLDRAFNLVGSSKLPRVVDSDLYITQARLWEKEDTKKSLGFLTRALDFLESAHMSVGPELLNNIAVLQYHLGLIPEAHGNIIKAKSVLPDANPELSLLLDYNLARCEEELGNTSVASEAYVSILEKHPSFIDARIRKCLLQLSNPNEETFKEIRHIMNADSQNLEVRAFFGWYLSKQKRRPVEDPEVRHCSQTLRHWHDDIYSLVQLGNAYMRQAREFRVHNDREKLKRQKLYIKAIQSYDQAIKFDPKNAHAAQGIAIILAQNRQFSKALLILSKVREAIKDATTLINIGNCLAELKQFSRAIEVFETVYSSTGESDTYGVLSCLGRVWLQRGRESKNVDYLKESVRYATLALEKNPENPSLLFNVAFVQFQLCELIRQKPENSRTVEDLNFAMQQLDASIETFTKLVSVEHPPYSPTSIEQRAKMAKNTTKRQLERAIQAQIEYEKSVAAKLEDARIQREKEKARRLAEEEALLKEKQERERQLQEERQKMQEEVLEWRKSQQKASEDDMSLSDDEEKQSGKKKKKDRKKRKSKSKQESSDSGVSEDDEIPLSDARNKTKKRRVNRRVISEEYTFDQDSDAEGNQEEEVSRTIEEKQDNDITDNQDDNKELNLFSEEDEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
171	Phosphorylation	FDFVLQKSGGNILGF HHHHHHHCCCCCHHH	38.68	25720772
834	Phosphorylation	SVEHPPYSPTSIEQR CCCCCCCCCCCHHHH	27.72	28889911
925	Phosphorylation	RKSQQKASEDDMSLS HHHHHHCCCCCCCCC	48.90	24763107
930	Phosphorylation	KASEDDMSLSDDEEK HCCCCCCCCCHHHHH	31.54	28889911
932	Phosphorylation	SEDDMSLSDDEEKQS CCCCCCCCHHHHHHH	35.39	28889911
954	Phosphorylation	RKKRKSKSKQESSDS HHHHHCCCCHHHCCC	46.81	21712547
958	Phosphorylation	KSKSKQESSDSGVSE HCCCCHHHCCCCCCC	36.63	24763107
959	Phosphorylation	SKSKQESSDSGVSED CCCCHHHCCCCCCCC	34.73	28889911
961	Phosphorylation	SKQESSDSGVSEDDE CCHHHCCCCCCCCCC	42.94	28889911
964	Phosphorylation	ESSDSGVSEDDEIPL HHCCCCCCCCCCCCH	38.54	28889911
998	Phosphorylation	EYTFDQDSDAEGNQE EECCCCCCCCCCCCH	32.84	28889911
1021	Phosphorylation	EKQDNDITDNQDDNK HHHCCCCCCCCCCCH	31.59	21712547
1034	Phosphorylation	NKELNLFSEEDEE-- CHHCCCCCCCCCC--	43.15	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TPR1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPR1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPR1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YOH8_SCHPO	leo1	physical	24385927
PAF1_SCHPO	paf1	physical	24385927
CDC73_SCHPO	cdc73	physical	24385927
SIB1_SCHPO	sib1	physical	24385927
PPX1_SCHPO	SPAC2F3.11	physical	24385927
YLW5_SCHPO	ski7	physical	24385927
YD72_SCHPO	SPAC32A11.02c	physical	24385927
YEJJ_SCHPO	abo1	physical	24385927
UBA4_SCHPO	SPAC2G11.10c	physical	24385927
RS9A_SCHPO	rps901	physical	24385927
ABC3_SCHPO	abc3	physical	24385927
CHL1_SCHPO	chl1	physical	24385927
SDHB_SCHPO	sdh2	physical	24385927
MU178_SCHPO	mug178	physical	24385927

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-930; SER-932; SER-959;SER-961; SER-964 AND SER-998, AND MASS SPECTROMETRY.
PubMed: 18257517