SLA1_SCHPO - dbPTM
SLA1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SLA1_SCHPO
UniProt AC O13736
Protein Name Actin cytoskeleton-regulatory complex protein sla1
Gene Name sla1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1420
Subcellular Localization Cell membrane
Peripheral membrane protein
Cytoplasmic side. Endosome membrane
Peripheral membrane protein
Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch . Cytoplasmic and cortical actin patches..
Protein Description Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity)..
Protein Sequence MANLPIIGIYKVLYSYEPQEINPGEEIPENEREISIVEDEIVCLLEKGEDDWYLVKRNVNSNDDDEEIGIVPSNYITEAEPSTKMKALYDYTQQSVDEISFQADQTLDCYGDTDSDWILVGFNNNFGLAPRNYVEGMDASSAPASQEPSASGVNAPTVSAPNSMVSPPPSFQPPSAAAPATSLPSDYNPPPPPPPPPAVEDQAADANEPDDYYSSGRAVSPEIPPTYTPKQADPLPAPPPPPPPTLPPQSTNTSQLPMPSRNVNNLGSQVNIPPPPATPSQPPRPPTNASTRSTGTSSSMAHSYDSPPSPSSPSDAYGDPNQHLKLRTDSHDDSRAYDSSSSMGNPAYEKWEVREVVGKKKKRTGILAINNKSIVLTFTKTMDAAQVWPVTDLVNYSSERKHVFIEFNSDSGITSLHLHASSNTNADNIIRALGDVAGSARAAGLREIAAASGSPMPKLPSDSALHRLNAASDAAGVNGGRTGDYEMSTVYGDRSARAEDHKPKDSSAGQKMGTVLYDFIAEAADELTVKANMRVVIVNDTASSDWWKCSVDGKEGVVPSNFIKPDTEGDAKSPPSSSKSGQGSSLSRRASKHESKHKRDSKHEARPESKHESHRESKSAEKDKKDKKDKKEDSKRSRSHSVSKPDSSKLRTWTDRTGAFKVEAEFLGYSDDKIHLHKTNGVKISVPSAKMSYKDLDYVELMTGKKVYSRTERKKDTQKQSHDHGHSHSKSHDREKEKEKKKDREHRKHRETEEEDEGPPPQPARPESTRPALAPPSSSHSNDKYDVIQERPKISYDWFDFFLRCGVDFTVCNRYTHNFNNEHLDEACIPSLNPDTLRTLGLKEGDIIRVMNHVNELNGVSTKPASAITPETKSTVNQIMSGGEALAAPVAVPAPIPAPVAEPAPPAAPAKEVVEKAPSPPATRPKSTTPQKFDDDAWANKPVTEPPVRASSVTVEPARVTESMNKMNISEEAKKPEAPSRPRTAPIPEPEEQKKAPVEKKDAEKSVQAPIPAQPTGNITIQNAYFTAPQPMAADPFQSPLYVQPTGFQPPPSALPIQPTGYMQPIPVQATGYQPLMVQPTGLQPHMTGVMPQVTGVMPQMTGVVPQMTGVMPQMTGVQVQKTGAMPQQPVNYGYQVAGMQPQATGIISQPTGIRAQATGIMTQPTGLHTQATGMMQPTGMQPQATGIMPQATGMMQPTGMQPQVTGIMPQSMPMQPQMTGVQVQKTGMVAQPMLSQYTGYQQNYTPTAMPAADGYGMQPSMNDTQAYYNMNAQTPVNYGFAGGQDTSFGYEQQQMYSPMQQQQQQYYGTEMQPDMGYQQPMMSNYYDPMQMQQQTPYGYNQTGMEGYSEYGYAQPAGNMANPMSYDPVSNASLYMPSDYNQQTQPANYYDSSFGGAQGANEAGKKASIYQATPDNPFGF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
220PhosphorylationYSSGRAVSPEIPPTY
CCCCCCCCCCCCCCC		18.8128889911
226PhosphorylationVSPEIPPTYTPKQAD
CCCCCCCCCCCCCCC		34.3728889911
268PhosphorylationRNVNNLGSQVNIPPP
CCCCCCCCCCCCCCC		33.8425720772
278PhosphorylationNIPPPPATPSQPPRP
CCCCCCCCCCCCCCC		29.2829996109
280PhosphorylationPPPPATPSQPPRPPT
CCCCCCCCCCCCCCC		51.4729996109
287PhosphorylationSQPPRPPTNASTRST
CCCCCCCCCCCCCCC		46.2129996109
293PhosphorylationPTNASTRSTGTSSSM
CCCCCCCCCCCCCCC		31.1425720772
298PhosphorylationTRSTGTSSSMAHSYD
CCCCCCCCCCCCCCC		24.7825720772
299PhosphorylationRSTGTSSSMAHSYDS
CCCCCCCCCCCCCCC		21.5425720772
306PhosphorylationSMAHSYDSPPSPSSP
CCCCCCCCCCCCCCC		30.4027738172
309PhosphorylationHSYDSPPSPSSPSDA
CCCCCCCCCCCCCCC		40.5828889911
311PhosphorylationYDSPPSPSSPSDAYG
CCCCCCCCCCCCCCC		60.2528889911
312PhosphorylationDSPPSPSSPSDAYGD
CCCCCCCCCCCCCCC		31.6328889911
314PhosphorylationPPSPSSPSDAYGDPN
CCCCCCCCCCCCCCC		36.5027738172
328PhosphorylationNQHLKLRTDSHDDSR
CCCEEECCCCCCCCC		52.9027738172
330PhosphorylationHLKLRTDSHDDSRAY
CEEECCCCCCCCCCC		28.3627738172
337PhosphorylationSHDDSRAYDSSSSMG
CCCCCCCCCCCCCCC		18.4325720772
339PhosphorylationDDSRAYDSSSSMGNP
CCCCCCCCCCCCCCH		21.3121712547
340PhosphorylationDSRAYDSSSSMGNPA
CCCCCCCCCCCCCHH		24.4321712547
341PhosphorylationSRAYDSSSSMGNPAY
CCCCCCCCCCCCHHH		28.4421712547
342PhosphorylationRAYDSSSSMGNPAYE
CCCCCCCCCCCHHHH		32.4325720772
452PhosphorylationLREIAAASGSPMPKL
HHHHHHHCCCCCCCC		34.7729996109
454PhosphorylationEIAAASGSPMPKLPS
HHHHHCCCCCCCCCC		18.6128889911
461PhosphorylationSPMPKLPSDSALHRL
CCCCCCCCHHHHHHH		55.4228889911
567PhosphorylationSNFIKPDTEGDAKSP
CCCCCCCCCCCCCCC		50.8529996109
573PhosphorylationDTEGDAKSPPSSSKS
CCCCCCCCCCCCCCC		43.7028889911
576PhosphorylationGDAKSPPSSSKSGQG
CCCCCCCCCCCCCCC		51.1024763107
577PhosphorylationDAKSPPSSSKSGQGS
CCCCCCCCCCCCCCC		47.7828889911
578PhosphorylationAKSPPSSSKSGQGSS
CCCCCCCCCCCCCCH		34.8725720772
580PhosphorylationSPPSSSKSGQGSSLS
CCCCCCCCCCCCHHH		37.9921712547
584PhosphorylationSSKSGQGSSLSRRAS
CCCCCCCCHHHHHHH		21.8821712547
585PhosphorylationSKSGQGSSLSRRASK
CCCCCCCHHHHHHHH		36.8721712547
587PhosphorylationSGQGSSLSRRASKHE
CCCCCHHHHHHHHHH		22.9721712547
591PhosphorylationSSLSRRASKHESKHK
CHHHHHHHHHHHHHC		32.5021712547
609PhosphorylationKHEARPESKHESHRE
CCCCCCHHHHHHHHH		41.8321712547
637PhosphorylationKKEDSKRSRSHSVSK
HHHHHHHHHHCCCCC		41.7029996109
639PhosphorylationEDSKRSRSHSVSKPD
HHHHHHHHCCCCCCC		22.7429996109
641PhosphorylationSKRSRSHSVSKPDSS
HHHHHHCCCCCCCHH		29.3629996109
643PhosphorylationRSRSHSVSKPDSSKL
HHHHCCCCCCCHHHC		41.3029996109
647PhosphorylationHSVSKPDSSKLRTWT
CCCCCCCHHHCCCCC		37.5929996109
648PhosphorylationSVSKPDSSKLRTWTD
CCCCCCHHHCCCCCC		42.9929996109
688PhosphorylationGVKISVPSAKMSYKD
CCEEECCCCCCCCCC		38.0627738172
768PhosphorylationPQPARPESTRPALAP
CCCCCCCCCCCCCCC		32.1921712547
866PhosphorylationGVSTKPASAITPETK
CCCCCCCCCCCCCCH		28.8227738172
869PhosphorylationTKPASAITPETKSTV
CCCCCCCCCCCHHHH		18.1327738172
919PhosphorylationEVVEKAPSPPATRPK
HHHHCCCCCCCCCCC		48.6628889911
923PhosphorylationKAPSPPATRPKSTTP
CCCCCCCCCCCCCCC		53.9629996109
927PhosphorylationPPATRPKSTTPQKFD
CCCCCCCCCCCCCCC		39.9528889911
928PhosphorylationPATRPKSTTPQKFDD
CCCCCCCCCCCCCCC		48.9328889911
929PhosphorylationATRPKSTTPQKFDDD
CCCCCCCCCCCCCCC		30.7128889911
951PhosphorylationTEPPVRASSVTVEPA
CCCCCCCCCEEEEHH		18.1221712547
952PhosphorylationEPPVRASSVTVEPAR
CCCCCCCCEEEEHHH		22.3328889911
980PhosphorylationAKKPEAPSRPRTAPI
HHCCCCCCCCCCCCC		63.0624763107
984PhosphorylationEAPSRPRTAPIPEPE
CCCCCCCCCCCCCHH		39.1928889911
1123PhosphorylationTGVQVQKTGAMPQQP
CCEEEEECCCCCCCC		17.0629996109
1145PhosphorylationAGMQPQATGIISQPT
CCCCCCCCCEECCCC		24.5429996109
1152PhosphorylationTGIISQPTGIRAQAT
CCEECCCCCCCCCCC		37.2929996109
1408PhosphorylationNEAGKKASIYQATPD
CHHHCCCEEEECCCC		30.6125720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SLA1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SLA1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SLA1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SLA1_SCHPO !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SLA1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-309; SER-311; SER-312;SER-454; SER-573; SER-577; SER-927 AND THR-929, AND MASS SPECTROMETRY.

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