CFR1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CFR1_SCHPO
• UniProt AC: Q92357
• Protein Name: Cell fusion protein cfr1
• Gene Name: cfr1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 620
• Subcellular Localization: Golgi apparatus .
• Protein Description: Required for cell fusion, independently of fus1. Appears to have a role in transporting proteins that are involved in mating. May act as a scaffold to retain cell fusion proteins in the cisternae of the Golgi. Degraded at the onset of mating and this leads to release of cell fusion proteins..
• Protein Sequence: MDDTNQFMVSVAKIDAGMAILLTPSFHIIEFPSVLLPNDATAGSIIDISVHHNKEEEIARETAFDDVQKEIFETYGQKLPSPPVLKLKNATQTSIVLEWDPLQLSTARLKSLCLYRNNVRVLNISNPMTTHNAKLSGLSLDTEYDFSLVLDTTAGTFPSKHITIKTLRMIDLTGIQVCVGNMVPNEMEALQKCIERIHARPIQTSVRIDTTHFICSSTGGPEYEKAKAANIPILGLDYLLKCESEGRLVNVSGFYIENRASYNANASINSVEAAQNAAPNLNATTEQPKNTAEVAQGAASAKAPQQTTQQGTQNSANAEPSSSASVPAEAPETEAEQSIDVSSDIGLRSDSSKPNEAPTSSENIKADQPENSTKQENPEEDMQIKDAEEHSNLESTPAAQQTSEVEANNHQEKPSSLPAVEQINVNEENNTPETEGLEDEKEENNTAAESLINQEETTSGEAVTKSTVESSANEEEAEPNEIIEENAVKSLLNQEGPATNEEVEKNNANSENANGLTDEKIIEAPLDTKENSDDDKPSPAAAEDIGTNGAIEEIPQVSEVLEPEKAHTTNLQLNALDKEEDLNITTVKQSSEPTADDNLIPNKEAEIIQSSDEFESVNID

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
267	Phosphorylation	ASYNANASINSVEAA HHCCCCCCCCHHHHH	23.31	25720772
270	Phosphorylation	NANASINSVEAAQNA CCCCCCCHHHHHHHH	21.47	29996109
300	Phosphorylation	EVAQGAASAKAPQQT HHHHHHHHCCCCCCC	29.75	29996109
351	Phosphorylation	DIGLRSDSSKPNEAP CCCCCCCCCCCCCCC	41.32	25720772
359	Phosphorylation	SKPNEAPTSSENIKA CCCCCCCCCCCCCCC	52.51	29996109
360	Phosphorylation	KPNEAPTSSENIKAD CCCCCCCCCCCCCCC	34.30	28889911
361	Phosphorylation	PNEAPTSSENIKADQ CCCCCCCCCCCCCCC	36.82	29996109
391	Phosphorylation	IKDAEEHSNLESTPA CCCHHHHCCCCCCCH	46.52	24763107
396	Phosphorylation	EHSNLESTPAAQQTS HHCCCCCCCHHHHCC	13.94	21712547
402	Phosphorylation	STPAAQQTSEVEANN CCCHHHHCCHHHCCC	18.12	21712547
403	Phosphorylation	TPAAQQTSEVEANNH CCHHHHCCHHHCCCC	34.99	21712547
446	Phosphorylation	DEKEENNTAAESLIN CHHHHCCHHHHHHHC	38.53	27738172
466	Phosphorylation	SGEAVTKSTVESSAN CCCEEHHHHHCCCCC	28.46	29996109
467	Phosphorylation	GEAVTKSTVESSANE CCEEHHHHHCCCCCH	29.83	25720772
470	Phosphorylation	VTKSTVESSANEEEA EHHHHHCCCCCHHHC	30.34	29996109
471	Phosphorylation	TKSTVESSANEEEAE HHHHHCCCCCHHHCC	22.93	25720772
490	Phosphorylation	IEENAVKSLLNQEGP HHHHHHHHHHHCCCC	31.33	24763107
510	Phosphorylation	VEKNNANSENANGLT HHHCCCCCCCCCCCC	29.80	21712547
528	Phosphorylation	IIEAPLDTKENSDDD HEECCCCCCCCCCCC	48.19	21712547
532	Phosphorylation	PLDTKENSDDDKPSP CCCCCCCCCCCCCCH	43.43	24763107
538	Phosphorylation	NSDDDKPSPAAAEDI CCCCCCCCHHHHHHH	32.67	29996109
547	Phosphorylation	AAAEDIGTNGAIEEI HHHHHHCCCCHHHHC	30.71	29996109
569	Phosphorylation	EPEKAHTTNLQLNAL CCCCCCCCCCCCCCC	24.86	24763107
590	Phosphorylation	NITTVKQSSEPTADD CCEEEECCCCCCCCC	30.83	24763107
591	Phosphorylation	ITTVKQSSEPTADDN CEEEECCCCCCCCCC	45.13	24763107
610	Phosphorylation	KEAEIIQSSDEFESV HHHHHCCCCHHHHCC	29.37	24763107
611	Phosphorylation	EAEIIQSSDEFESVN HHHHCCCCHHHHCCC	25.45	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CFR1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CFR1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CFR1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YB2G_SCHPO	SPBC31F10.16	physical	26771498
YHOF_SCHPO	SPBC428.15	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.