SST2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SST2_SCHPO
• UniProt AC: Q9P371
• Protein Name: AMSH-like protease sst2
• Gene Name: sst2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 435
• Subcellular Localization: Cytoplasm . Endosome .
• Protein Description: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in the multivesicular body (MVB) sorting pathway. Required for ubiquitin-dependent sorting of proteins into the endosome and subsequent trafficking to the vacuole. May regulate MVB sorting through deubiquitination of ubiquitinated ESCRT proteins..
• Protein Sequence: MNILQGSEAPLSYEEIASRAGAFDFNKNIPLKNWLRTSTTISKQAHVYVSEHDYSNGVFLLFRYCELFMKCQKHPDAAAYKKELFDYYQGVRNALEEIELIKPIVKEQYEQYQCQKNDLDDLKKLSMKDSQPSLEKPVSYVDEPILEQWALSDLQILPPSSTDLLSPDSQKLSKSSSDLPQFDYPSLNSSPTFNSNLPISSSRFEKTSLSDSKLVSPEPLDDNKDIQFIKKPIYTRTSEPRPKPAGTFKIHAYTEGGKPLRTIYLPKLLKKVFLDVVKPNTKKNLETCGILCGKLRQNAFFITHLVIPLQEATSDTCGTTDEASLFEFQDKHNLLTLGWIHTHPTQTCFMSSVDLHTHCSYQLMLPEAIAIVMAPSKNTSGIFRLLDPEGLQTIVKCRKPGLFHPHEGKVYTMVAQPGHVREINSKLQVVDLRVK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
175	Phosphorylation	DSQKLSKSSSDLPQF CHHHHCCCCCCCCCC	31.53	24763107
184	Phosphorylation	SDLPQFDYPSLNSSP CCCCCCCCCCCCCCC	8.94	21712547
189	Phosphorylation	FDYPSLNSSPTFNSN CCCCCCCCCCCCCCC	42.88	25720772
190	Phosphorylation	DYPSLNSSPTFNSNL CCCCCCCCCCCCCCC	27.21	21712547
192	Phosphorylation	PSLNSSPTFNSNLPI CCCCCCCCCCCCCCC	37.08	28889911
216	Phosphorylation	LSDSKLVSPEPLDDN CCCCCCCCCCCCCCC	33.70	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SST2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SST2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SST2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MED4_SCHPO	pmc4	physical	26771498
UBC_HUMAN	UBC	physical	26368668

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-192, AND MASSSPECTROMETRY.
PubMed: 18257517