dbPTM

SNX41_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SNX41_SCHPO
UniProt AC	O60107
Protein Name	Sorting nexin-41
Gene Name	snx41
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	586
Subcellular Localization	Cytoplasm . Endosome membrane Peripheral membrane protein . Endomembrane system Peripheral membrane protein . Endosome and other perivacuolar punctate structures..
Protein Description	May be required for cytoplasm to vacuole transport (Cvt) and pexophagy (By similarity). Has a role in meiosis..
Protein Sequence	MDFFEDNNPFSGSDNRSASSAVNVEPKVEPSQHQGSSSVKENAISQPNESFQSRNMFFQKDVDSVVDSALDPNGIVITGAMKAESGSHIVYIIKLQDSEIHHRYSEFASLRVQLSRLYPTCLVPPLPDKHKIMDYLINVTKNQRMSRMLEERKRLLQLFLRRVAQHPILGLSEVFRKFLSRHVSWKEVLHSPPISCLPKDLLKAPPADPSSKENAELYKELPIPSKTLVPRDNYDDVGKNFLMLEDTLQQYSIVAQEESNLFNQIVLSNSKYCLAHSTLGAMFNALSLSESGKLLTALEKVGQANDHTCLASIDFMHNFVIAVIEPLQELSKDAKNMRHIFIFRKMKFIQQVMVEELLTRKKSFLHLLERRERHAARLQQAIGEVDGDVILNRESEATLGVNNAQTSRSTIPEEDPLFNDEESKEPSVPLMGTDQPLENYHDGNGEQTEECLRDLRHNQSQDFETVSQDTSLTSVTVLPRTIRDVFDRIRFVLNGLTDNNVEVSRHNNIGRTAESVTHLTDMLLITTKDVAFVTDRVNFEFQRYQDTHRQDLNRILNRLTDSHIDWANRNLRIWNSVQESLKTYVS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	FSGSDNRSASSAVNV CCCCCCCCCCCCCCC	38.46	21712547
19	Phosphorylation	GSDNRSASSAVNVEP CCCCCCCCCCCCCCC	21.78	28889911
20	Phosphorylation	SDNRSASSAVNVEPK CCCCCCCCCCCCCCC	35.63	29996109
31	Phosphorylation	VEPKVEPSQHQGSSS CCCCCCCCCCCCCCH	27.13	28889911
36	Phosphorylation	EPSQHQGSSSVKENA CCCCCCCCCHHHHCC	16.93	24763107
37	Phosphorylation	PSQHQGSSSVKENAI CCCCCCCCHHHHCCC	46.07	29996109
38	Phosphorylation	SQHQGSSSVKENAIS CCCCCCCHHHHCCCC	38.62	25720772
50	Phosphorylation	AISQPNESFQSRNMF CCCCCCHHHHHCCCH	34.91	24763107
53	Phosphorylation	QPNESFQSRNMFFQK CCCHHHHHCCCHHHH	24.50	21712547
64	Phosphorylation	FFQKDVDSVVDSALD HHHHCHHHHHHHCCC	24.72	21712547
460	Phosphorylation	RDLRHNQSQDFETVS HHHHHCCCCCCEECC	36.71	25720772
465	Phosphorylation	NQSQDFETVSQDTSL CCCCCCEECCCCCCC	26.00	25720772
467	Phosphorylation	SQDFETVSQDTSLTS CCCCEECCCCCCCCE	29.74	25720772
470	Phosphorylation	FETVSQDTSLTSVTV CEECCCCCCCCEEEE	20.28	25720772
473	Phosphorylation	VSQDTSLTSVTVLPR CCCCCCCCEEEECCC	22.40	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SNX41_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SNX41_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SNX41_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SNX41_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SNX41_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, AND MASSSPECTROMETRY.	18257517 [Abstract]