| UniProt ID | SNF1_SCHPO | |
|---|---|---|
| UniProt AC | O74536 | |
| Protein Name | SNF1-like protein kinase ssp2 {ECO:0000303|PubMed:22140232} | |
| Gene Name | ssp2 {ECO:0000303|PubMed:22140232} | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 576 | |
| Subcellular Localization | Cytoplasm . Nucleus . Nuclear translocation occurs under nitrogen and glucose starvation conditions and depends on Thr-189 phosphorylation by ssp1 (PubMed:22375066). | |
| Protein Description | Serine/threonine protein kinase essential for release from glucose repression via the phosphorylation of scr1 upon glucose deprivation. [PubMed: 22140232 Catalytic subunit of the AMP-activated protein kinase complex also known as the SNF1 kinase complex (Snf1c), a central regulator of cellular energy homeostasis, which, in response to a fall in intracellular ATP levels, activates energy-producing pathways and inhibits energy-consuming processes] | |
| Protein Sequence | MQPQEVDLMENSTMRNGARVLPPEAISKRHIGPYIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPHIIKLYDVITTPTDIVMVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAGPEVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVYVMPDFLSPGAQSLIRRMIVADPMQRITIQEIRRDPWFNVNLPDYLRPMEEVQGSYADSRIVSKLGEAMGFSEDYIVEALRSDENNEVKEAYNLLHENQVIQEKSHLSKSKRVDSFLSVSPPAFSEYTSELQKKSKQELIDPTLEGPRWTVSDPPTYAKQTIDSNICVLVPTAEKNKLEMRTLADAASAVDTSQSTRKKSRRNKWHFGVRCRGDAPEILLAVYRALQRAGAQFTVPKPVNGKYRSDMYTIKSRWEIPHCKREGKNTYAYIELQLYEVMPGCFMLDVKSNGYKDIYSHPERTADHGMDDLKSSFPFLDLCAMLVCKLFSA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 178 | Phosphorylation | KIADFGLSNIMTDGN EEEHHCCCCCCCCCC | 25.37 | 27738172 | |
| 182 | Phosphorylation | FGLSNIMTDGNFLKT HCCCCCCCCCCCCCC | 36.64 | 29996109 | |
| 189 | Phosphorylation | TDGNFLKTSCGSPNY CCCCCCCCCCCCCCC | 31.25 | 22375066 | |
| 190 | Phosphorylation | DGNFLKTSCGSPNYA CCCCCCCCCCCCCCC | 18.20 | 28889911 | |
| 193 | Phosphorylation | FLKTSCGSPNYAAPE CCCCCCCCCCCCCCH | 17.82 | 29996109 | |
| 362 | Phosphorylation | SKSKRVDSFLSVSPP CCCCCCCCHHCCCCC | 25.82 | 21712547 | |
| 365 | Phosphorylation | KRVDSFLSVSPPAFS CCCCCHHCCCCCHHH | 20.66 | 29996109 | |
| 367 | Phosphorylation | VDSFLSVSPPAFSEY CCCHHCCCCCHHHHH | 23.07 | 28889911 | |
| 372 | Phosphorylation | SVSPPAFSEYTSELQ CCCCCHHHHHHHHHH | 31.62 | 21712547 | |
| 374 | Phosphorylation | SPPAFSEYTSELQKK CCCHHHHHHHHHHHH | 17.86 | 21712547 | |
| 375 | Phosphorylation | PPAFSEYTSELQKKS CCHHHHHHHHHHHHH | 16.21 | 29996109 | |
| 382 | Phosphorylation | TSELQKKSKQELIDP HHHHHHHHHHHHCCC | 46.75 | 28889911 | |
| 442 | Phosphorylation | SAVDTSQSTRKKSRR HHCCCCHHHHCHHHC | 29.91 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SNF1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SNF1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SNF1_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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