dbPTM

PSO2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PSO2_SCHPO
UniProt AC	Q10264
Protein Name	DNA cross-link repair protein pso2/snm1
Gene Name	pso2
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	560
Subcellular Localization	Nucleus.
Protein Description	Required for DNA interstrand cross-link repair. This requires cleavage of cross-linked DNA to generate DNA double strand breaks (DSBs). This protein may have 5' exonuclease activity on single-stranded and double-stranded DNA, which could be necessary for the processing of DNA double strand breaks prior to religation..
Protein Sequence	MSKRKSSSILDFFKKSNNGKNMWGNEAVSVEKTDSTTKPSTVKNAISSSQIKNEKFSQEVLLQFNDPSFTSEVGESPQWQSFGDANILEPLKNELVKNEESTMSELLLCPICGITLESLTVDANIHVNDCLDGRTTEAVSKKLKKDSVVKADPSNSSTFPISDSCKQALLPLPGKQINVRSVVPFYKLMPYNIPFAVDAFAYGAIDGVEAYFLSHFHSDHYGGLTPKWKHGPIYCSEVTGNLLINVMHVDEQYVKRLKLNQPYNIMGITVYVLDANHCPGSAMFVFETLQSNQTRRVLHCGDFRASKDHVMHPVLREKTIHKVYLDTTYLNPKYTFPPQADVVQACADKAISIKKSTDSRLLVVVSTYSIGKEKVAVAIAKSLSSRIYVVPRKMHIIKQLENQDLIDLLTDDPTQASVHMVTMMGIHPNSLLDYLEQYNSSFDKIIGYKVTGWTFQPLENRAQLSSSLDSIISRPPKFVEYDLRAIRGSTDKVAAFVAPYSEHSSFYDLTMFCLSMNIGHIIPTVNVGSQRSREKMNVWLDRWAWRRKKQGLLSLENVDW

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
6	Phosphorylation	--MSKRKSSSILDFF --CCCCCCHHHHHHH	33.09	25720772
7	Phosphorylation	-MSKRKSSSILDFFK -CCCCCCHHHHHHHH	25.16	24763107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PSO2_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PSO2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PSO2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PLI1_SCHPO	pli1	genetic	24192486
RAD1_SCHPO	rad1	genetic	24192486
RAD13_SCHPO	rad13	genetic	24192486
HUS1_SCHPO	hus1	genetic	24192486
VPS24_SCHPO	vps24	genetic	24192486
RAD17_SCHPO	rad17	genetic	24192486
ATCX_SCHPO	SPAC24B11.12c	genetic	24192486
UBC13_SCHPO	ubc13	genetic	24192486
RFA3_SCHPO	ssb3	genetic	24192486
MET8_SCHPO	SPAC4D7.06c	genetic	24192486
FAN1_SCHPO	fan1	genetic	25319828

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PSO2_SCHPO

Related Literatures of Post-Translational Modification