CAPZA_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAPZA_SCHPO
• UniProt AC: Q10434
• Protein Name: F-actin-capping protein subunit alpha
• Gene Name: acp1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 256
• Subcellular Localization: Cytoplasm . Septum. Localizes to cell tips during interphase.
• Protein Description: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Competes with formin cdc12 for attachment to the actin filaments barbed ends. Slowly replaces cdc12 on the barbed ends in preparation for filament disassembly during contractile ring constriction..
• Protein Sequence: MEKEAIYKLIRESPPGEVNQVVHDIRDIGLSDEEAIHEQLKLYHEDYNSSVSISDDEKVIISADNRLEGNRYYDQVLQKSFTINYETMEAENVEDYTEAIKIPDEIVKQIKKVASDHYLSDVTFGIIKKSDEVESFTIVLVSSKYNPKNYWNGSWRCICNYNVSEKKLEGRSHIRVHYYEDGNVWLDASRPISATVEETSKLYEVLAQVENGIQQSFNVELSSLNDKKFKELRRQLPVTRQKINWENVSGIRMRNT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	DIRDIGLSDEEAIHE HHHHCCCCCHHHHHH	37.45	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAPZA_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAPZA_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAPZA_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COFI_SCHPO	adf1	genetic	16866873
PROF_SCHPO	cdc3	genetic	16866873
MLR4_SCHPO	cdc4	genetic	16866873
AIN1_SCHPO	ain1	genetic	16866873
FIMB_SCHPO	fim1	genetic	16866873
RNG2_SCHPO	rng2	genetic	16866873
CAPZB_SCHPO	acp2	genetic	25143407
CAPZB_SCHPO	acp2	physical	27206859

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, AND MASSSPECTROMETRY.
PubMed: 18257517