MAC1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAC1_SCHPO
• UniProt AC: Q10268
• Protein Name: Membrane-anchored protein 1
• Gene Name: mac1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 756
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell septum. Cell tip.
• Protein Description: Required for correct cell separation at high temperatures..
• Protein Sequence: MIRNTLAFLAILFLLIPTALLIIGSVSVPSTRMTLAKVEGTEFGIFGTCTGNGTDCTETSFGYNASSSLIDDFYYKGDKRLVLSKVLITHIISAFLSFLSAIFVFFSIFLVNQAVNIINIIVVFITTLLTCLAFAIELVLFLPHNTWQSYVTAGAIGSDLIAILALCLRSVSISRIGQKSARLEHVDTMNSSYSSYKTDVKYPLALDDKLSSVPTLPKFHDALTSTSEFGPPSDSGDTVGTTQYPGDIKYATGYESTVASPVPSRVAKLSSRDTPSIIADYDEFRKSESSPSRSSVLSTSKPEVHETEGYCPHKTGNRPGFPSLNIPRTRPTTAGIANTQFDLEPYRNRQAGSISSEGTDSRFFDVENQVSVAQTPSVKPEMFPKTARPFAAIHANASSTQLRNTENITHPGIPNHFAKTTSSVFDEPPATRMPQTRSPVNDHSSFPSDLPIKGEMSTNMTGAPRVGSRNNSSNDLHAQAGMLKNVGNGPRNAPRNNSSNNLHAQGGMPMNMRGPRGAPRNNSSGDLHIQSGMPMNGRNGPRDTSRNNSSSDLYAQSGMHPNMNNGHRGAPRNNSSNDLHAHGGMPVNMRGPRNTSRNNSSSEFNAQIPMNLRNGPRNASRSNSSTDLFGQSGIPGNSRGMPTSPNSRNNSALDLSMHGIPLANNSRQFKRPSYGNMSRPSFELNGSRNPSHGSLNTAHAGMGYGPRSMMRDPQNLSNVPPVSNTLDQLSGNADFELPVRGNRNNRRGPGGNRMIR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	N-linked_Glycosylation	IFGTCTGNGTDCTET EEEEECCCCCCCCCC	31.85	-
64	N-linked_Glycosylation	TETSFGYNASSSLID CCCCCCCCCCCHHCC	33.45	-
188	Phosphorylation	ARLEHVDTMNSSYSS CCCEEHHCCCHHCCC	19.70	25720772
190	N-linked_Glycosylation	LEHVDTMNSSYSSYK CEEHHCCCHHCCCCC	29.87	-
191	Phosphorylation	EHVDTMNSSYSSYKT EEHHCCCHHCCCCCC	21.60	25720772
192	Phosphorylation	HVDTMNSSYSSYKTD EHHCCCHHCCCCCCC	24.83	25720772
193	Phosphorylation	VDTMNSSYSSYKTDV HHCCCHHCCCCCCCC	11.06	25720772
194	Phosphorylation	DTMNSSYSSYKTDVK HCCCHHCCCCCCCCC	29.19	25720772
195	Phosphorylation	TMNSSYSSYKTDVKY CCCHHCCCCCCCCCC	23.55	27738172
196	Phosphorylation	MNSSYSSYKTDVKYP CCHHCCCCCCCCCCC	16.39	27738172
198	Phosphorylation	SSYSSYKTDVKYPLA HHCCCCCCCCCCCCC	37.48	25720772
211	Phosphorylation	LALDDKLSSVPTLPK CCCCCHHHCCCCCHH	34.72	25720772
212	Phosphorylation	ALDDKLSSVPTLPKF CCCCHHHCCCCCHHH	42.42	24763107
215	Phosphorylation	DKLSSVPTLPKFHDA CHHHCCCCCHHHHHH	54.24	24763107
224	Phosphorylation	PKFHDALTSTSEFGP HHHHHHCCCCCCCCC	31.51	25720772
225	Phosphorylation	KFHDALTSTSEFGPP HHHHHCCCCCCCCCC	30.68	21712547
226	Phosphorylation	FHDALTSTSEFGPPS HHHHCCCCCCCCCCC	27.34	25720772
227	Phosphorylation	HDALTSTSEFGPPSD HHHCCCCCCCCCCCC	30.60	21712547
233	Phosphorylation	TSEFGPPSDSGDTVG CCCCCCCCCCCCCCC	47.76	24763107
235	Phosphorylation	EFGPPSDSGDTVGTT CCCCCCCCCCCCCCC	42.79	29996109
238	Phosphorylation	PPSDSGDTVGTTQYP CCCCCCCCCCCCCCC	25.10	25720772
241	Phosphorylation	DSGDTVGTTQYPGDI CCCCCCCCCCCCCCC	13.34	29996109
242	Phosphorylation	SGDTVGTTQYPGDIK CCCCCCCCCCCCCCE	21.85	29996109
250	Phosphorylation	QYPGDIKYATGYEST CCCCCCEECCCCCCC	15.10	29996109
252	Phosphorylation	PGDIKYATGYESTVA CCCCEECCCCCCCCC	36.89	29996109
254	Phosphorylation	DIKYATGYESTVASP CCEECCCCCCCCCCC	11.44	21712547
256	Phosphorylation	KYATGYESTVASPVP EECCCCCCCCCCCCC	21.50	25720772
257	Phosphorylation	YATGYESTVASPVPS ECCCCCCCCCCCCCH	14.25	21712547
260	Phosphorylation	GYESTVASPVPSRVA CCCCCCCCCCCHHHH	23.30	28889911
264	Phosphorylation	TVASPVPSRVAKLSS CCCCCCCHHHHHHCC	39.35	21712547
270	Phosphorylation	PSRVAKLSSRDTPSI CHHHHHHCCCCCCCE	23.71	24763107
271	Phosphorylation	SRVAKLSSRDTPSII HHHHHHCCCCCCCEE	44.61	21712547
274	Phosphorylation	AKLSSRDTPSIIADY HHHCCCCCCCEEECH	20.16	29996109
276	Phosphorylation	LSSRDTPSIIADYDE HCCCCCCCEEECHHH	28.81	29996109
281	Phosphorylation	TPSIIADYDEFRKSE CCCEEECHHHHHCCC	14.35	25720772
287	Phosphorylation	DYDEFRKSESSPSRS CHHHHHCCCCCCCHH	38.15	21712547
289	Phosphorylation	DEFRKSESSPSRSSV HHHHCCCCCCCHHHH	55.42	25720772
290	Phosphorylation	EFRKSESSPSRSSVL HHHCCCCCCCHHHHC	23.89	21712547
292	Phosphorylation	RKSESSPSRSSVLST HCCCCCCCHHHHCCC	46.90	27738172
294	Phosphorylation	SESSPSRSSVLSTSK CCCCCCHHHHCCCCC	29.18	29996109
295	Phosphorylation	ESSPSRSSVLSTSKP CCCCCHHHHCCCCCC	26.43	29996109
298	Phosphorylation	PSRSSVLSTSKPEVH CCHHHHCCCCCCCCC	28.60	21712547
299	Phosphorylation	SRSSVLSTSKPEVHE CHHHHCCCCCCCCCC	36.29	21712547
300	Phosphorylation	RSSVLSTSKPEVHET HHHHCCCCCCCCCCC	42.72	27738172
329	Phosphorylation	PSLNIPRTRPTTAGI CCCCCCCCCCCCCCC	35.33	25720772
332	Phosphorylation	NIPRTRPTTAGIANT CCCCCCCCCCCCCCC	26.45	29996109
333	Phosphorylation	IPRTRPTTAGIANTQ CCCCCCCCCCCCCCC	26.10	25720772
353	Phosphorylation	YRNRQAGSISSEGTD CCCCCCCCCCCCCCC	23.47	25720772
356	Phosphorylation	RQAGSISSEGTDSRF CCCCCCCCCCCCCCC	38.07	25720772
396	N-linked_Glycosylation	PFAAIHANASSTQLR CCEEEECCCCCCCCC	26.62	-
398	Phosphorylation	AAIHANASSTQLRNT EEEECCCCCCCCCCC	33.45	29996109
399	Phosphorylation	AIHANASSTQLRNTE EEECCCCCCCCCCCC	20.12	29996109
400	Phosphorylation	IHANASSTQLRNTEN EECCCCCCCCCCCCC	29.18	25720772
407	N-linked_Glycosylation	TQLRNTENITHPGIP CCCCCCCCCCCCCCC	42.28	-
420	Phosphorylation	IPNHFAKTTSSVFDE CCCCCCCCCCCCCCC	28.60	25720772
421	Phosphorylation	PNHFAKTTSSVFDEP CCCCCCCCCCCCCCC	20.49	25720772
422	Phosphorylation	NHFAKTTSSVFDEPP CCCCCCCCCCCCCCC	29.72	25720772
423	Phosphorylation	HFAKTTSSVFDEPPA CCCCCCCCCCCCCCC	25.39	25720772
438	Phosphorylation	TRMPQTRSPVNDHSS CCCCCCCCCCCCCCC	36.27	28889911
445	Phosphorylation	SPVNDHSSFPSDLPI CCCCCCCCCCCCCCC	37.44	29996109
448	Phosphorylation	NDHSSFPSDLPIKGE CCCCCCCCCCCCCCC	50.17	29996109
457	Phosphorylation	LPIKGEMSTNMTGAP CCCCCCCCCCCCCCC	16.60	21712547
458	Phosphorylation	PIKGEMSTNMTGAPR CCCCCCCCCCCCCCC	27.91	21712547
459	N-linked_Glycosylation	IKGEMSTNMTGAPRV CCCCCCCCCCCCCCC	20.79	-
461	Phosphorylation	GEMSTNMTGAPRVGS CCCCCCCCCCCCCCC	32.06	21712547
468	Phosphorylation	TGAPRVGSRNNSSND CCCCCCCCCCCCCCC	29.04	21712547
470	N-linked_Glycosylation	APRVGSRNNSSNDLH CCCCCCCCCCCCCHH	55.20	-
471	N-linked_Glycosylation	PRVGSRNNSSNDLHA CCCCCCCCCCCCHHH	45.78	-
472	Phosphorylation	RVGSRNNSSNDLHAQ CCCCCCCCCCCHHHH	33.78	25720772
473	Phosphorylation	VGSRNNSSNDLHAQA CCCCCCCCCCHHHHH	36.16	21712547
496	N-linked_Glycosylation	GPRNAPRNNSSNNLH CCCCCCCCCCCCCCC	52.23	-
497	N-linked_Glycosylation	PRNAPRNNSSNNLHA CCCCCCCCCCCCCCC	48.36	-
498	Phosphorylation	RNAPRNNSSNNLHAQ CCCCCCCCCCCCCCC	37.68	29996109
499	Phosphorylation	NAPRNNSSNNLHAQG CCCCCCCCCCCCCCC	31.68	29996109
521	N-linked_Glycosylation	GPRGAPRNNSSGDLH CCCCCCCCCCCCCCE	52.23	-
522	N-linked_Glycosylation	PRGAPRNNSSGDLHI CCCCCCCCCCCCCEE	38.54	-
523	Phosphorylation	RGAPRNNSSGDLHIQ CCCCCCCCCCCCEEC	38.97	29996109
524	Phosphorylation	GAPRNNSSGDLHIQS CCCCCCCCCCCEECC	38.15	29996109
544	Phosphorylation	GRNGPRDTSRNNSSS CCCCCCCCCCCCCCH	30.76	29996109
545	Phosphorylation	RNGPRDTSRNNSSSD CCCCCCCCCCCCCHH	36.98	29996109
547	N-linked_Glycosylation	GPRDTSRNNSSSDLY CCCCCCCCCCCHHHH	53.13	-
548	N-linked_Glycosylation	PRDTSRNNSSSDLYA CCCCCCCCCCHHHHH	42.00	-
549	Phosphorylation	RDTSRNNSSSDLYAQ CCCCCCCCCHHHHHH	34.47	29996109
550	Phosphorylation	DTSRNNSSSDLYAQS CCCCCCCCHHHHHHC	29.96	29996109
551	Phosphorylation	TSRNNSSSDLYAQSG CCCCCCCHHHHHHCC	31.30	25720772
573	N-linked_Glycosylation	GHRGAPRNNSSNDLH CCCCCCCCCCCCCCH	52.23	-
574	N-linked_Glycosylation	HRGAPRNNSSNDLHA CCCCCCCCCCCCCHH	48.36	-
575	Phosphorylation	RGAPRNNSSNDLHAH CCCCCCCCCCCCHHC	33.78	29996109
576	Phosphorylation	GAPRNNSSNDLHAHG CCCCCCCCCCCHHCC	36.16	29996109
594	N-linked_Glycosylation	VNMRGPRNTSRNNSS CCCCCCCCCCCCCCC	45.61	-
595	Phosphorylation	NMRGPRNTSRNNSSS CCCCCCCCCCCCCCC	30.28	29996109
596	Phosphorylation	MRGPRNTSRNNSSSE CCCCCCCCCCCCCCC	36.24	29996109
598	N-linked_Glycosylation	GPRNTSRNNSSSEFN CCCCCCCCCCCCCEE	53.13	-
599	N-linked_Glycosylation	PRNTSRNNSSSEFNA CCCCCCCCCCCCEEC	42.00	-
600	Phosphorylation	RNTSRNNSSSEFNAQ CCCCCCCCCCCEECC	38.50	29996109
601	Phosphorylation	NTSRNNSSSEFNAQI CCCCCCCCCCEECCC	35.69	29996109
602	Phosphorylation	TSRNNSSSEFNAQIP CCCCCCCCCEECCCC	46.13	25720772
618	N-linked_Glycosylation	NLRNGPRNASRSNSS CCCCCCCCCCCCCCC	45.46	-
620	Phosphorylation	RNGPRNASRSNSSTD CCCCCCCCCCCCCCC	39.53	25720772
622	Phosphorylation	GPRNASRSNSSTDLF CCCCCCCCCCCCCCC	38.27	25720772
623	N-linked_Glycosylation	PRNASRSNSSTDLFG CCCCCCCCCCCCCCC	38.58	-
624	Phosphorylation	RNASRSNSSTDLFGQ CCCCCCCCCCCCCCC	35.54	28889911
625	Phosphorylation	NASRSNSSTDLFGQS CCCCCCCCCCCCCCC	30.14	29996109
626	Phosphorylation	ASRSNSSTDLFGQSG CCCCCCCCCCCCCCC	36.22	29996109
643	Phosphorylation	GNSRGMPTSPNSRNN CCCCCCCCCCCCCCC	48.18	29996109
644	Phosphorylation	NSRGMPTSPNSRNNS CCCCCCCCCCCCCCC	19.06	29996109
647	Phosphorylation	GMPTSPNSRNNSALD CCCCCCCCCCCCCCC	39.51	25720772
649	N-linked_Glycosylation	PTSPNSRNNSALDLS CCCCCCCCCCCCCHH	46.78	-
651	Phosphorylation	SPNSRNNSALDLSMH CCCCCCCCCCCHHHC	33.48	25720772
656	Phosphorylation	NNSALDLSMHGIPLA CCCCCCHHHCCCCCC	14.38	25720772
664	N-linked_Glycosylation	MHGIPLANNSRQFKR HCCCCCCCCCCCCCC	55.48	-
666	Phosphorylation	GIPLANNSRQFKRPS CCCCCCCCCCCCCCC	27.54	25720772
673	Phosphorylation	SRQFKRPSYGNMSRP CCCCCCCCCCCCCCC	50.10	29996109
676	N-linked_Glycosylation	FKRPSYGNMSRPSFE CCCCCCCCCCCCCEE	19.61	-
685	N-linked_Glycosylation	SRPSFELNGSRNPSH CCCCEEECCCCCCCC	38.91	-
691	Phosphorylation	LNGSRNPSHGSLNTA ECCCCCCCCCCCCCC	43.99	29996109
694	Phosphorylation	SRNPSHGSLNTAHAG CCCCCCCCCCCCCCC	17.02	25720772
697	Phosphorylation	PSHGSLNTAHAGMGY CCCCCCCCCCCCCCC	25.72	29996109
715	N-linked_Glycosylation	SMMRDPQNLSNVPPV HHCCCCCCCCCCCCC	51.31	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAC1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAC1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAC1_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of MAC1_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-438, AND MASSSPECTROMETRY.
PubMed: 18257517