| UniProt ID | AAKG_SCHPO | |
|---|---|---|
| UniProt AC | Q10343 | |
| Protein Name | 5'-AMP-activated protein kinase subunit gamma | |
| Gene Name | cbs2 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 334 | |
| Subcellular Localization | Nucleus . Cytoplasm . | |
| Protein Description | Adenine nucleotides-binding subunit gamma of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (ssp2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits.. | |
| Protein Sequence | MTDVQETQKGALKEIQAFIRSRTSYDVLPTSFRLIVFDVTLFVKTSLSLLTLNNIVSAPLWDSEANKFAGLLTMADFVNVIKYYYQSSSFPEAIAEIDKFRLLGLREVERKIGAIPPETIYVHPMHSLMDACLAMSKSRARRIPLIDVDGETGSEMIVSVLTQYRILKFISMNCKETAMLRVPLNQMTIGTWSNLATASMETKVYDVIKMLAEKNISAVPIVNSEGTLLNVYESVDVMHLIQDGDYSNLDLSVGEALLKRPANFDGVHTCRATDRLDGIFDAIKHSRVHRLFVVDENLKLEGILSLADILNYIIYDKTTTPGVPEQTDNFESAV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|
|---|---|---|---|---|---|---|
Oops, there are no PTM records of AAKG_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AAKG_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AAKG_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AAKG_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| DAD2_SCHPO | dad2 | genetic | 18818364 | |
| SSU72_SCHPO | ssu72 | genetic | 18818364 | |
| GDIR_SCHPO | SPAC6F12.06 | genetic | 18818364 | |
| MU183_SCHPO | mug183 | genetic | 18818364 | |
| REB1_SCHPO | reb1 | genetic | 18818364 | |
| BZZ1_SCHPO | bzz1 | genetic | 18818364 | |
| SRB11_SCHPO | srb11 | genetic | 18818364 | |
| YOU5_SCHPO | pph3 | genetic | 18818364 | |
| MUB1_SCHPO | SPBC31F10.10c | genetic | 18818364 | |
| EIF2A_SCHPO | SPBC4B4.04 | genetic | 18818364 | |
| PP2C2_SCHPO | ptc2 | genetic | 18818364 | |
| SET1_SCHPO | set1 | genetic | 18818364 | |
| MU154_SCHPO | mug154 | genetic | 18818364 | |
| JHD1_SCHPO | epe1 | genetic | 18818364 | |
| RNC1_SCHPO | rnc1 | genetic | 18818364 | |
| VPH2_SCHPO | vph2 | genetic | 18818364 | |
| YAC5_SCHPO | cph1 | genetic | 18818364 | |
| RES2_SCHPO | res2 | genetic | 18818364 | |
| ELP3_SCHPO | elp3 | genetic | 18818364 | |
| HIR1_SCHPO | hip1 | genetic | 18818364 | |
| CEK1_SCHPO | cek1 | genetic | 18818364 | |
| SNF1_SCHPO | ssp2 | physical | 22375066 | |
| PPK9_SCHPO | ppk9 | physical | 19371376 | |
| PUR1_SCHPO | ade4 | physical | 19371376 | |
| AAKB_SCHPO | amk2 | physical | 19371376 | |
| SNF1_SCHPO | ssp2 | physical | 19371376 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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