GDIR_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GDIR_SCHPO
• UniProt AC: O14224
• Protein Name: Rho GDP-dissociation inhibitor
• Gene Name: SPAC6F12.06
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 205
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them..
• Protein Sequence: MSVNNEVSADQHNPELEDDTFEHGPPVSLGEKKSLNEYMKMDAEDESLQKWKASLGITGTGYSPSNDRRTVVILKLSLLVDGRDPVDVNMEDAASVEQIRKKGFTIKEGSEFKIGVKFRVQHEVISGLRYVQTVRRRGFVVDKTSTMIGSYGPSETPYDFTSEPDEAPTGMLARGHYEANGKFVDDDKVVHHEFVWAFDVAKSWK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSVNNEVSA ------CCCCCCCCC	33.29	24763107
8	Phosphorylation	MSVNNEVSADQHNPE CCCCCCCCCCCCCCC	21.68	29996109
20	Phosphorylation	NPELEDDTFEHGPPV CCCCCCCCCCCCCCC	43.15	29996109
28	Phosphorylation	FEHGPPVSLGEKKSL CCCCCCCCCCCCCCH	36.11	29996109
34	Phosphorylation	VSLGEKKSLNEYMKM CCCCCCCCHHHHHCC	47.71	19547744
63	Phosphorylation	GITGTGYSPSNDRRT CCCCCCCCCCCCCCE	24.17	28889911
65	Phosphorylation	TGTGYSPSNDRRTVV CCCCCCCCCCCCEEE	45.48	19547744

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GDIR_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GDIR_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GDIR_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PST2_SCHPO	pst2	genetic	19547744
ABP1_SCHPO	cbp1	genetic	18818364
ZRG17_SCHPO	zrg17	genetic	22681890
RIA1_SCHPO	ria1	genetic	22681890
SGF29_SCHPO	sgf29	genetic	22681890

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63, AND MASSSPECTROMETRY.
PubMed: 18257517