ADH_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADH_SCHPO
• UniProt AC: P00332
• Protein Name: Alcohol dehydrogenase
• Gene Name: adh1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 350
• Subcellular Localization: Cytoplasm.
• Protein Sequence: MTIPDKQLAAVFHTHGGPENVKFEEVPVAEPGQDEVLVNIKYTGVCHTDLHALQGDWPLPAKMPLIGGHEGAGVVVKVGAGVTRLKIGDRVGVKWMNSSCGNCEYCMKAEETICPHIQLSGYTVDGTFQHYCIANATHATIIPESVPLEVAAPIMCAGITCYRALKESKVGPGEWICIPGAGGGLGHLAVQYAKAMAMRVVAIDTGDDKAELVKSFGAEVFLDFKKEADMIEAVKAATNGGAHGTLVLSTSPKSYEQAAGFARPGSTMVTVSMPAGAKLGADIFWLTVKMLKICGSHVGNRIDSIEALEYVSRGLVKPYYKVQPFSTLPDVYRLMHENKIAGRIVLDLSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
83	Phosphorylation	VKVGAGVTRLKIGDR EEECCCCCEEEECCE	29.39	24763107
205	Phosphorylation	MRVVAIDTGDDKAEL CEEEEEECCCCHHHH	36.08	28889911
249	Phosphorylation	AHGTLVLSTSPKSYE CCEEEEEECCCCCHH	21.25	24763107
250	Phosphorylation	HGTLVLSTSPKSYEQ CEEEEEECCCCCHHH	44.91	28889911
251	Phosphorylation	GTLVLSTSPKSYEQA EEEEEECCCCCHHHH	27.27	25720772
254	Phosphorylation	VLSTSPKSYEQAAGF EEECCCCCHHHHCCC	36.97	24763107
255	Phosphorylation	LSTSPKSYEQAAGFA EECCCCCHHHHCCCC	20.42	25720772
304	Phosphorylation	HVGNRIDSIEALEYV CCCCCCCHHHHHHHH	21.69	28889911
310	Phosphorylation	DSIEALEYVSRGLVK CHHHHHHHHHCCCCC	12.46	25720772
312	Phosphorylation	IEALEYVSRGLVKPY HHHHHHHHCCCCCCC	21.52	25720772
319	Phosphorylation	SRGLVKPYYKVQPFS HCCCCCCCEECCCCC	15.36	25720772
320	Phosphorylation	RGLVKPYYKVQPFST CCCCCCCEECCCCCC	17.14	25720772
349	Phosphorylation	GRIVLDLSK------ EEEEEECCC------	35.67	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ADH_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADH_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADH_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YL8J_SCHPO	loz1	genetic	24003116
ADH4_SCHPO	adh4	genetic	24003116
YL8J_SCHPO	loz1	genetic	24831008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-205 AND THR-250, ANDMASS SPECTROMETRY.
PubMed: 18257517