dbPTM

VPS35_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VPS35_SCHPO
UniProt AC	O74552
Protein Name	Vacuolar protein sorting-associated protein 35
Gene Name	vps35
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	836
Subcellular Localization	Membrane Peripheral membrane protein.
Protein Description	Plays a role in vesicular protein sorting. Required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor vps10. Required to form proper forespore membranes..
Protein Sequence	MNGINTANEEITRSLEESLNICKQSSRLMQRNLQTGRLMDAFRNCSISLVEMRNSALTPKQYYELYMFNMESLRLLGGTLLETHLNGTHNLMDLYELVQYAGSIVPRLYLMITVGSAYLETPNALVREIMNDLLDMCRGVQHPLRGLFLRHYLLTQTRKGLPLGSEDEEDASRKGTVLDSVKFLVINFTEMNKLWVRIQHLGPIKEFSKRTQERNELKVLVGLNLVRLSQLNLDIDTYRDHVLPAIIEQIIECRDSLAQEYLVEVICQAFSDNMHLQTLDTYFGTVIKLSPSVNVTQLVVAMLNRLTDYVQREYESDSSNEDESETVTEKLGDIKINEEVQQKDEQECPGDKVIPPEYAIQEVLWSHVVEVIQSRSGLPLDCIVSILSSILNFFLRCYPYKPQYADRVFQYINEHIINQPSLRSALHERPLQKSLCAILLLPLTYFPSFSYCLELQNFLPVFNAQDPNLRYDIARMIVQKIIEKGHSLSELTEAQELLGFVSVIIEKKGVDSLDDLQNVALMVHYLNNDDPQIQIEILRSLKDTFIKAGENVKYLLPVVVNRCIFLARNFRIFKCMDWAEKVRLLWEFVNTCINVLYKNGDSLELCLALYLSAAEMADQENYPDFAYEFFTQAFSIYEESVLDSELQYQQLLMIIGKLQKTRNFSVDDYDTLITKCTLYASKLLKKPDQCCGIYLASHLWWQVASGEDSRPFQDPKRVLECLQKSLKIADACMDQLTSLKLFINILERYFYYYDQHCESIIAKHISGLIDLTEQNMRSILISSPADLIASDPRAYASSIWEVANVSVIDSLKNHLERATAYAEKRSEDERWSSIFQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
314	Phosphorylation	TDYVQREYESDSSNE HHHHHHHHCCCCCCC	23.95	25720772
316	Phosphorylation	YVQREYESDSSNEDE HHHHHHCCCCCCCCH	41.72	28889911
318	Phosphorylation	QREYESDSSNEDESE HHHHCCCCCCCCHHH	44.32	28889911
319	Phosphorylation	REYESDSSNEDESET HHHCCCCCCCCHHHH	49.59	29996109
324	Phosphorylation	DSSNEDESETVTEKL CCCCCCHHHHHHHHH	51.38	25720772
326	Phosphorylation	SNEDESETVTEKLGD CCCCHHHHHHHHHCC	41.84	25720772
783	Phosphorylation	MRSILISSPADLIAS HHHHHHCCHHHHHHC	19.67	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of VPS35_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of VPS35_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VPS35_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PEX10_SCHPO	pas4	genetic	22681890
PVG2_SCHPO	pvg2	genetic	22681890
ARB1_SCHPO	arb1	genetic	22681890
YBX5_SCHPO	SPBC17D1.05	genetic	22681890
ATC3_SCHPO	cta3	genetic	22681890
ELL1_SCHPO	ell1	genetic	22681890
MU146_SCHPO	mug146	genetic	22681890
TPP1_SCHPO	tpp1	genetic	22681890
PNPH_SCHPO	SPAC1805.16c	genetic	22681890
MIK1_SCHPO	mik1	genetic	22681890
MLH1_SCHPO	mlh1	genetic	22681890
VHT1_SCHPO	vht1	genetic	22681890
YIP5_SCHPO	SPAC227.06	genetic	22681890
PT191_SCHPO	SPBC16A3.16	genetic	22681890
YHJ1_SCHPO	SPBPB10D8.01	genetic	22681890
YIQ9_SCHPO	SPAC824.09c	genetic	22681890
YNVB_SCHPO	SPBC3H7.11	genetic	22681890
RCQ1_SCHPO	rqc1	genetic	22681890
YIP4_SCHPO	SPAC644.13c	genetic	22681890
YBJB_SCHPO	SPBC337.11	genetic	22681890
YK98_SCHPO	whi2	genetic	22681890
YAJ1_SCHPO	gto2	genetic	22681890
HAT1_SCHPO	hat1	genetic	22681890
TAD1_SCHPO	SPBC16A3.06	genetic	22681890
DNJC7_SCHPO	SPBC543.02c	genetic	22681890
YD1K_SCHPO	SPAC4G9.20c	genetic	22681890
UPP2_SCHPO	SPAC1399.04c	genetic	22681890
YEG5_SCHPO	mga2	genetic	22681890
6PGL_SCHPO	SPCC16C4.10	genetic	22681890
YKW2_SCHPO	SPAP32A8.02	genetic	22681890
PAC2_SCHPO	pac2	genetic	22681890
YN1B_SCHPO	SPBC577.11	genetic	22681890
YNU4_SCHPO	SPBC28E12.04	genetic	22681890
FAM50_SCHPO	xap5	genetic	22681890
VTA1_SCHPO	vta1	genetic	22681890
YH51_SCHPO	SPBC215.01	genetic	22681890
PFD5_SCHPO	bob1	genetic	22681890
YQJ9_SCHPO	SPCC1840.09	genetic	22681890
YI81_SCHPO	SPAPJ695.01c	genetic	22681890
STR3_SCHPO	str3	genetic	22681890
YE76_SCHPO	SPAC4A8.06c	genetic	22681890
AP2S_SCHPO	aps2	genetic	22681890
HSP9_SCHPO	hsp9	genetic	22681890
SEC7B_SCHPO	sec72	genetic	22681890
ALY1_SCHPO	SPBC839.02	genetic	22681890
VAM7_SCHPO	SPCC594.06c	genetic	22681890
ATP10_SCHPO	atp10	genetic	22681890
SHE9_SCHPO	SPAC823.13c	genetic	22681890
YDX3_SCHPO	SPAC4C5.03	genetic	22681890
YGR1_SCHPO	crs103	genetic	22681890
PIMT_SCHPO	pcm2	genetic	22681890
EFTS_SCHPO	tsf1	genetic	22681890
CTBL1_SCHPO	SPAC1952.06c	genetic	22681890
YJ03_SCHPO	rhn1	genetic	22681890
MU134_SCHPO	SPAC10F6.15	genetic	22681890
YAKB_SCHPO	SPAC1F7.11c	genetic	22681890
YH5B_SCHPO	SPBC215.11c	genetic	22681890
YJ52_SCHPO	SPCP20C8.02c	genetic	22681890
TRK1_SCHPO	trk1	genetic	22681890
AP3M_SCHPO	apm3	genetic	22681890
KU80_SCHPO	pku80	genetic	22681890
ZIP2_SCHPO	zip2	genetic	22681890
FRP2_SCHPO	frp2	genetic	22681890
MGR2_SCHPO	mgr2	genetic	22681890
AP2M_SCHPO	apm4	genetic	22681890
ARGJ_SCHPO	SPBC1271.14	genetic	22681890
MU178_SCHPO	mug178	genetic	22681890
YJ44_SCHPO	SPCC70.04c	genetic	22681890
RL25B_SCHPO	rpl2502	genetic	22681890
DEP1_SCHPO	dep1	genetic	22681890
VTC2_SCHPO	SPAC14C4.11	genetic	22681890
MU147_SCHPO	mug147	genetic	22681890
EXO70_SCHPO	exo70	genetic	22681890
YHG1_SCHPO	fmd2	genetic	22681890
ARP8_SCHPO	arp8	genetic	22681890
PGT1_SCHPO	pgt1	genetic	22681890
XLF1_SCHPO	xlf1	genetic	22681890
YK82_SCHPO	bdf2	genetic	22681890
MTO1_SCHPO	SPBC30B4.06c	genetic	22681890
TRM10_SCHPO	trm10	genetic	22681890
PPK8_SCHPO	ppk8	genetic	22681890
YE04_SCHPO	SPAC17H9.04c	genetic	22681890
RAD1_SCHPO	rad1	genetic	22681890
NAA40_SCHPO	naa40	genetic	22681890
CAT1_SCHPO	cat1	genetic	22681890
HRQ1_SCHPO	hrq1	genetic	22681890
SKB5_SCHPO	skb5	genetic	22681890
OXR1_SCHPO	mug63	genetic	22681890
SST6_SCHPO	sst6	genetic	22681890
ARZ1_SCHPO	arz1	genetic	22681890
BUN62_SCHPO	bun62	genetic	22681890
YE08_SCHPO	SPAC17H9.08	genetic	22681890
YQJ8_SCHPO	pdi5	genetic	22681890
YGBA_SCHPO	SPBC25B2.10	genetic	22681890
YDA4_SCHPO	SPAC1F12.04c	genetic	22681890
YAN8_SCHPO	SPAC3H1.08c	genetic	22681890
YF8B_SCHPO	SPAC27D7.11c	genetic	22681890
MEI4_SCHPO	mei4	genetic	22681890
YKK1_SCHPO	SPAC2E1P3.01	genetic	22681890
YD1E_SCHPO	SPAC4G9.14	genetic	22681890
MU113_SCHPO	mug113	genetic	22681890
OTC_SCHPO	arg3	genetic	22681890
MPD2_SCHPO	mpd2	genetic	22681890
YNS7_SCHPO	SPBC18H10.07	genetic	22681890
ATS1_SCHPO	ats1	genetic	22681890
YO45_SCHPO	SPBC36B7.05c	genetic	22681890
YA07_SCHPO	SPAC5H10.07	genetic	22681890
YIT2_SCHPO	SPAC105.02c	genetic	22681890
YAJB_SCHPO	SPAC30D11.11	genetic	22681890
ATF21_SCHPO	atf21	genetic	22681890
TRX2_SCHPO	trx2	genetic	22681890
MAD3_SCHPO	mad3	genetic	22681890
GAS5_SCHPO	gas5	genetic	22681890
YIOB_SCHPO	SPAP27G11.11c	genetic	22681890
ERG5_SCHPO	erg5	genetic	22681890
YMR1_SCHPO	ymr1	genetic	22681890
YNL5_SCHPO	SPBC27.05	genetic	22681890
NAA35_SCHPO	mak10	genetic	22681890
HHP2_SCHPO	hhp2	genetic	22681890
UGGG_SCHPO	gpt1	genetic	22681890
GLYD_SCHPO	SPAC24C9.12c	genetic	22681890
PHD1_SCHPO	hos2	genetic	22681890
YCL3_SCHPO	SPCC16A11.03c	genetic	22681890
FCF2_SCHPO	fcf2	genetic	22681890
YJNK_SCHPO	SPCC24B10.20	genetic	22681890
FFT1_SCHPO	fft1	genetic	22681890
ATP12_SCHPO	atp12	genetic	22681890
DMA1_SCHPO	dma1	genetic	22681890
SGF73_SCHPO	sgf73	genetic	22681890
ASH2_SCHPO	ash2	genetic	22681890
CSN12_SCHPO	SPAC1B3.08	genetic	22681890
RL43B_SCHPO	rpl4302	genetic	22681890
HBS1_SCHPO	SPBC25B2.01	genetic	22681890
FSC1_SCHPO	fsc1	genetic	22681890
PSD3_SCHPO	psd3	genetic	22681890
YCF9_SCHPO	SPCC1393.09c	genetic	22681890
GPA2_SCHPO	gpa2	genetic	22681890
HIBCH_SCHPO	snr1	genetic	22681890
ANM3_SCHPO	rmt3	genetic	22681890
YA29_SCHPO	SPAC2F7.09c	genetic	22681890
CTL1_SCHPO	ctl1	genetic	22681890
MU111_SCHPO	mug111	genetic	22681890
NU124_SCHPO	nup124	genetic	22681890
YEAF_SCHPO	SPACUNK4.15	genetic	22681890
LYS4_SCHPO	lys2	genetic	22681890
YB22_SCHPO	SPBC31F10.02	genetic	22681890
SOL1_SCHPO	sol1	genetic	22681890
TLS1_SCHPO	tls1	genetic	22681890
YD58_SCHPO	nas6	genetic	22681890
YKT4_SCHPO	SPAPB1E7.04c	genetic	22681890
PEX6_SCHPO	pex6	genetic	22681890
YE98_SCHPO	erp2	genetic	22681890
YJIA_SCHPO	SPCC5E4.10c	genetic	22681890
YB1D_SCHPO	pdi3	genetic	22681890
COQ10_SCHPO	coq10	genetic	22681890
HIS1_SCHPO	his1	genetic	22681890
PTR2_SCHPO	ptr2	genetic	22681890
CORO_SCHPO	crn1	genetic	22681890
HASP_SCHPO	hrk1	genetic	22681890
YO48_SCHPO	SPBC36B7.08c	genetic	22681890
AROG_SCHPO	SPAP8A3.07c	genetic	22681890
FKBPH_SCHPO	SPAC27F1.06c	genetic	22681890
YF07_SCHPO	SPAC56E4.07	genetic	22681890
CYB51_SCHPO	SPBC29A10.16c	genetic	22681890
ELOF1_SCHPO	SPAC1B3.02c	genetic	22681890
YCF8_SCHPO	SPCC1393.08	genetic	22681890
BYR3_SCHPO	byr3	genetic	22681890
ATC2_SCHPO	SPAPB2B4.04c	genetic	22681890
YOND_SCHPO	SPBC1105.13c	genetic	22681890
PYRD_SCHPO	ura3	genetic	22681890
MUG14_SCHPO	mug14	genetic	22681890
YGVA_SCHPO	def1	genetic	22681890
YD49_SCHPO	SPAC22H10.09	genetic	22681890
AZET_SCHPO	aca1	genetic	22681890
RM01_SCHPO	SPAC1610.02c	genetic	22681890
RSSA1_SCHPO	rps001	genetic	22681890
YAD8_SCHPO	SPAC4G8.08	genetic	22681890
ATP11_SCHPO	atp11	genetic	22681890
YBKD_SCHPO	gmh6	genetic	22681890
YH7G_SCHPO	SPBC16G5.16	genetic	22681890
PDT1_SCHPO	pdt1	genetic	22681890
TYW4_SCHPO	SPBC19C7.08c	genetic	22681890
OMH1_SCHPO	omh1	genetic	22681890
ARG56_SCHPO	arg11	genetic	22681890
MTG1_SCHPO	mtg1	genetic	22681890
RL27A_SCHPO	rpl2701	genetic	22681890
SET1_SCHPO	set1	genetic	22681890
TEA3_SCHPO	tea3	genetic	22681890
PUS1_SCHPO	pus1	genetic	22681890
YOD1_SCHPO	SPBC18A7.01	genetic	22681890
YOS9_SCHPO	SPBC21C3.09c	genetic	22681890
EME1_SCHPO	eme1	genetic	22681890
YDHG_SCHPO	SPAC6G9.16c	genetic	22681890
ALM1_SCHPO	alm1	genetic	22681890
YD56_SCHPO	SPAC6C3.06c	genetic	22681890
YBPD_SCHPO	SPBC16H5.13	genetic	22681890
ACH1_SCHPO	SPAC1952.09c	genetic	22681890
YA05_SCHPO	SPAC5H10.05c	genetic	22681890
YB63_SCHPO	SPBC12C2.03c	genetic	22681890
OAZ_SCHPO	spa1	genetic	22681890
YCY1_SCHPO	SPCC1235.01	genetic	22681890
ETFA_SCHPO	etf1	genetic	22681890
YNH1_SCHPO	SPBC32H8.01c	genetic	22681890
YFY7_SCHPO	SPAC9.07c	genetic	22681890
YNQA_SCHPO	SPBC19C2.10	genetic	22681890
VPS20_SCHPO	vps20	genetic	22681890
SVP26_SCHPO	SPCC1795.10c	genetic	22681890
YB64_SCHPO	SPBC12C2.04	genetic	22681890
RGA6_SCHPO	rga6	genetic	22681890
TRM6_SCHPO	gcd10	genetic	22681890
YHDD_SCHPO	cha4	genetic	22681890
RS4B_SCHPO	rps402	genetic	22681890
YC67_SCHPO	SPCC1919.07	genetic	22681890
YB0A_SCHPO	SPBC25H2.10c	genetic	22681890
IVN1_SCHPO	ivn1	genetic	22681890
SNX41_SCHPO	mug186	genetic	22681890
SDE2_SCHPO	sde2	genetic	22681890
POF15_SCHPO	pof15	genetic	22681890
ARV1_SCHPO	arv1	genetic	22681890
VMS1_SCHPO	vms1	genetic	22681890
YA99_SCHPO	SPAC13G6.09	genetic	22681890
YHKH_SCHPO	SPBC660.17c	genetic	22681890
NHP6_SCHPO	nhp6	genetic	22681890
IWR1_SCHPO	iwr1	genetic	22681890
YDL6_SCHPO	SPAC3A12.06c	genetic	22681890
YJN2_SCHPO	SPCC24B10.02c	genetic	22681890
PMT3_SCHPO	pmt3	genetic	22681890
TREA_SCHPO	ntp1	genetic	22681890
PEX13_SCHPO	pex13	genetic	22681890
TIP1_SCHPO	tip1	genetic	22681890
LGUL_SCHPO	glo1	genetic	22681890
YDJ7_SCHPO	SPAC57A10.07	genetic	22681890
MIC19_SCHPO	SPBC25H2.09	genetic	22681890
YOH8_SCHPO	leo1	genetic	22681890
YA32_SCHPO	SPAC18B11.02c	genetic	22681890
SPM1_SCHPO	pmk1	genetic	22681890
MVP1_SCHPO	mvp1	genetic	22681890
YG41_SCHPO	cxr1	genetic	22681890
YJC7_SCHPO	SPCC736.07c	genetic	22681890
YK42_SCHPO	tos4	genetic	22681890
RS4C_SCHPO	rps403	genetic	22681890
UBP2_SCHPO	ubp2	genetic	22681890
FAT2_SCHPO	SPCC1827.03c	genetic	22681890
MOK11_SCHPO	mok11	genetic	22681890
YKI7_SCHPO	SPAC630.07c	genetic	22681890
ENG1_SCHPO	eng1	genetic	22681890
YFE6_SCHPO	gmh5	genetic	22681890
RER1_SCHPO	rer1	genetic	22681890
VPS25_SCHPO	vps25	genetic	22681890
LEU1_SCHPO	leu3	genetic	22681890
YBI8_SCHPO	oga1	genetic	22681890
YKEA_SCHPO	SPAC1805.10	genetic	22681890
FHP_SCHPO	SPAC869.02c	genetic	22681890
SCK2_SCHPO	sck2	genetic	22681890
GPD2_SCHPO	gpd2	genetic	22681890
RF1M_SCHPO	mrf1	genetic	22681890
CHAC_SCHPO	SPBC31F10.03	genetic	22681890
APS1_SCHPO	aps1	genetic	22681890
YGT9_SCHPO	SPBC4C3.09	genetic	22681890
PPK2_SCHPO	tea5	genetic	22681890
YQO6_SCHPO	SPCC569.06	genetic	22681890
CWF11_SCHPO	cwf11	genetic	22681890
RS10A_SCHPO	rps1001	genetic	22681890
YEAA_SCHPO	SPACUNK4.10	genetic	22681890
MOC3_SCHPO	moc3	genetic	22681890
YNT3_SCHPO	SPBC9B6.03	genetic	22681890
YNK4_SCHPO	SPBC29B5.04c	genetic	22681890
YF51_SCHPO	sac12	genetic	22681890
LNP_SCHPO	lnp1	genetic	22681890
YHY1_SCHPO	mni1	genetic	22681890
ULP1_SCHPO	ulp1	genetic	22681890
YA39_SCHPO	SPAC18B11.09c	genetic	22681890
NUDC_SCHPO	SPBC19F8.02	genetic	22681890

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VPS35_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316; SER-318 ANDSER-783, AND MASS SPECTROMETRY.	18257517 [Abstract]