dbPTM

STR3_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	STR3_SCHPO
UniProt AC	Q92341
Protein Name	Siderophore iron transporter 3
Gene Name	str3
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	630
Subcellular Localization	Membrane Multi-pass membrane protein .
Protein Description	Involved in the transport of siderophore iron and so has a role in iron homeostasis..
Protein Sequence	MEAKETHSISDHEVELQDAKPEEKSENGNFVFEKAFSSDEEKGSGYNTNETYSKMDNSLQHRGVSKIEAVRDSIYQNKRGMYLAYAFGIAILACSWASAIQSSTTYSYQVYATASFNRTSMISTLEIATAIISSVCKPILGKFSDITSRPMTYTLVLLFYVIGFIVVASSSTISAYVIGSVFISIGSSGLDYLNTLVVGDLTSLKWRGFMTALLSTPYIATVWFTGFIVQGIIDSNWRWGYGMFAIIMPAVMTPAVIILMYLERQANKDENIKKIINYQTEEKNKNKQSKWQKLWKAVLEVDLFGLILLGVGWSILLLPFSLTSYAKNGWKNPSMIAMMVVGGVILIAYSGYEMFIAPYPSCPRRVMNRTFITAVIIDFFYYLAGYLQSMYFTTYTWILYDWSYRDWTYFNNTMTIALCVFGVFAGAMHRVFHRYKYLQIIGLVIKIVGYGILIRPNFAATGKVDLAWSLILIGMGGSFSVVGSQVSCQASVPHQDLAIASSLLPLYTNIGGAIGAAIASPIFSNKVPKYLREYLPSSINDTQVYNFYSDSSLIREYPVGTEIRDGAIKAYSRSMFFLLVPAVSLSFIPLAAAFWQSNFYLGNQQNAVEGDQDHKKKGDKETTQEEKIII

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MEAKETHSISDHE --CCCCCCCCCCCCC	21.88	25720772
8	Phosphorylation	MEAKETHSISDHEVE CCCCCCCCCCCCCEE	31.07	25720772
10	Phosphorylation	AKETHSISDHEVELQ CCCCCCCCCCCEEEC	35.61	28889911
25	Phosphorylation	DAKPEEKSENGNFVF CCCCCCCCCCCCEEE	39.30	24763107
37	Phosphorylation	FVFEKAFSSDEEKGS EEEEECCCCCCCCCC	41.56	25720772
38	Phosphorylation	VFEKAFSSDEEKGSG EEEECCCCCCCCCCC	42.46	28889911
44	Phosphorylation	SSDEEKGSGYNTNET CCCCCCCCCCCCCHH	49.53	24763107
46	Phosphorylation	DEEKGSGYNTNETYS CCCCCCCCCCCHHHH	22.10	29996109
48	Phosphorylation	EKGSGYNTNETYSKM CCCCCCCCCHHHHCC	26.42	29996109
53	Phosphorylation	YNTNETYSKMDNSLQ CCCCHHHHCCCCCHH	28.99	21712547
58	Phosphorylation	TYSKMDNSLQHRGVS HHHCCCCCHHCCCCC	25.74	24763107
65	Phosphorylation	SLQHRGVSKIEAVRD CHHCCCCCHHHHHHH	30.64	25720772
73	Phosphorylation	KIEAVRDSIYQNKRG HHHHHHHHHHHCCCH	16.78	24763107
622	Phosphorylation	KKKGDKETTQEEKII HHCCCCCCCCCCCCC	39.25	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of STR3_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of STR3_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of STR3_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of STR3_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of STR3_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10 AND SER-38, AND MASSSPECTROMETRY.	18257517 [Abstract]