RGA6_SCHPO - dbPTM
RGA6_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RGA6_SCHPO
UniProt AC O43027
Protein Name Probable Rho-GTPase-activating protein 6
Gene Name rga6
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 733
Subcellular Localization
Protein Description
Protein Sequence MTLNPSTLNNGTLGDLKEHKDVVLSSNAQTDEKRFEEPSLEVGGSLAKVENGLSTSISSSASNLEGQQAPFFTKQNSCLSRFRELAQTYNIHEINLEEYVSQIKEVKQSLYSDDSVFNESKSSSPPDAHTDKYFTPCGSPTKLIHSTLLEERDTPSSLEHVSFYLQESAVSEVRFDKPSNNGPLGRSSLNLSSLSHELQTSQDSPSLSATNQLSSSDTLEPLQYPPSSFGSQRQFNASQDSPKRSPSKGSWSSILRRPSLTYSPKRQSTGLHRRSLTNYFKFPHRNAHQHNAIAHNPSVFGKPIGDLTSDPTNLCKFTFPTPECAPPSLLLPHIFAQCVHFLSLNALHVPGIFRISGSGPVIKAITEYFYSPPHFWLDETSEIFKRIGFPSYIDIAAVLKRYIMLLPGGLFTHKDILNLLVPLYVDSSRVKVPIDIRNEMAALCFSQIDSYVRFSILCSLLALLHQIATRTQELENGMENTKDSTLMKPEALGIIFGPLLLGNSSTDLSKSCPSGNVNDLMRFETEKARVEAKIVEGLIIHWPEVLLKINSLDIPNCFSDVGLTDQVAIFTPAVPKEDSPEQIPENVNASEESYPNVKHISKLPLINDSSDNESGNQENDDAVANESTKVVVDNQQPQPKISTVSDTAVPSMSFANNISSRSVISAATDSKPSTRTSPPFVNNTKPIVAKSPVTVTASSETNKKSQKINKKASPRVSLWTKLFGKFRSNKKKS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
39PhosphorylationEKRFEEPSLEVGGSL
HHHCCCCCEECCCEE		40.2021712547
45PhosphorylationPSLEVGGSLAKVENG
CCEECCCEEEEEECC		21.1624763107
56PhosphorylationVENGLSTSISSSASN
EECCCCCEECCCCCC		19.6627738172
58PhosphorylationNGLSTSISSSASNLE
CCCCCEECCCCCCCC		20.2921712547
59PhosphorylationGLSTSISSSASNLEG
CCCCEECCCCCCCCC		28.4021712547
60PhosphorylationLSTSISSSASNLEGQ
CCCEECCCCCCCCCC		29.0021712547
62PhosphorylationTSISSSASNLEGQQA
CEECCCCCCCCCCCC		43.8527738172
112PhosphorylationEVKQSLYSDDSVFNE
HHHHHHCCCCHHCCC		39.9921712547
115PhosphorylationQSLYSDDSVFNESKS
HHHCCCCHHCCCCCC		33.3321712547
122PhosphorylationSVFNESKSSSPPDAH
HHCCCCCCCCCCCCC		45.3824763107
124PhosphorylationFNESKSSSPPDAHTD
CCCCCCCCCCCCCCC		47.7621712547
130PhosphorylationSSPPDAHTDKYFTPC
CCCCCCCCCCCCCCC		35.5921712547
133PhosphorylationPDAHTDKYFTPCGSP
CCCCCCCCCCCCCCC		18.5929996109
135PhosphorylationAHTDKYFTPCGSPTK
CCCCCCCCCCCCCCH		17.9924763107
139PhosphorylationKYFTPCGSPTKLIHS
CCCCCCCCCCHHHHH		35.7924763107
141PhosphorylationFTPCGSPTKLIHSTL
CCCCCCCCHHHHHHH		39.9328889911
250PhosphorylationKRSPSKGSWSSILRR
CCCCCCCCHHHHHCC		27.7621712547
252PhosphorylationSPSKGSWSSILRRPS
CCCCCCHHHHHCCCC		14.8121712547
259PhosphorylationSSILRRPSLTYSPKR
HHHHCCCCCCCCCCC		31.3729996109
261PhosphorylationILRRPSLTYSPKRQS
HHCCCCCCCCCCCCC		26.7029996109
263PhosphorylationRRPSLTYSPKRQSTG
CCCCCCCCCCCCCCC		20.7921712547
275PhosphorylationSTGLHRRSLTNYFKF
CCCCCCCCCCCCCCC		39.2325720772
277PhosphorylationGLHRRSLTNYFKFPH
CCCCCCCCCCCCCCC		29.1729996109
279PhosphorylationHRRSLTNYFKFPHRN
CCCCCCCCCCCCCCC		11.6925720772
504PhosphorylationGPLLLGNSSTDLSKS
HHHHCCCCCCCHHHH		32.5824763107
505PhosphorylationPLLLGNSSTDLSKSC
HHHCCCCCCCHHHHC		29.9129996109
506PhosphorylationLLLGNSSTDLSKSCP
HHCCCCCCCHHHHCC		40.5621712547
511PhosphorylationSSTDLSKSCPSGNVN
CCCCHHHHCCCCCHH		28.0821712547
514PhosphorylationDLSKSCPSGNVNDLM
CHHHHCCCCCHHHHH		47.5329996109
609PhosphorylationKLPLINDSSDNESGN
CCCCCCCCCCCCCCC		34.7924763107
610PhosphorylationLPLINDSSDNESGNQ
CCCCCCCCCCCCCCC		47.5225720772
614PhosphorylationNDSSDNESGNQENDD
CCCCCCCCCCCCCCH		49.6625720772
662PhosphorylationANNISSRSVISAATD
CCCCCCCHHHHHHCC		26.2525720772
665PhosphorylationISSRSVISAATDSKP
CCCCHHHHHHCCCCC		15.0829996109
668PhosphorylationRSVISAATDSKPSTR
CHHHHHHCCCCCCCC		40.2925720772
691PhosphorylationTKPIVAKSPVTVTAS
CCCCEECCCEEEECC		18.1824763107
694PhosphorylationIVAKSPVTVTASSET
CEECCCEEEECCCCC		18.6121712547
701PhosphorylationTVTASSETNKKSQKI
EEECCCCCCHHCHHC		55.0429996109
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RGA6_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RGA6_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RGA6_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RHO2_SCHPOrho2physical
26960792
CDC42_SCHPOcdc42physical
26960792
RGA4_SCHPOrga4genetic
26960792
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RGA6_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-141, AND MASSSPECTROMETRY.

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