dbPTM

YO45_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	YO45_SCHPO
UniProt AC	Q9HGN5
Protein Name	Putative E3 ubiquitin-protein ligase C36B7.05c
Gene Name	SPBC36B7.05c
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	279
Subcellular Localization	Cytoplasm . Nucleus . Endosome membrane Peripheral membrane protein. Vacuole membrane Peripheral membrane protein.
Protein Description	Functions as an E3 ubiquitin-protein ligase. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate..
Protein Sequence	MDEDETTYPEALRRLLIETPAAIWQLDDESAQCNNCGGPFTWFRRRHHCRWCGKLFCYNCCNSFAKLPVSSVSVDPTEDLIPQDMFIRDPDFLANDNDDDNDSQDSSWINVRVCVNCRQQLSELKELDLPYPITTCLNDDTTTRSNNQVIQSSCGNNLQRIEEPDDFVECPVCYAPLSSFKTLSERESHVANCLSNNSSSPRNMTEFLKHARRYISMQLSETSPCLGQECIICFEEFAAGDRVARIEYCLCIFHLKCYRDWLSTGAAGCPVHAATLHLS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
178	Phosphorylation	PVCYAPLSSFKTLSE CCCCCCHHHCCCHHH	32.44	25720772
179	Phosphorylation	VCYAPLSSFKTLSER CCCCCHHHCCCHHHH	38.14	25720772
182	Phosphorylation	APLSSFKTLSERESH CCHHHCCCHHHHHHH	33.24	25720772
184	Phosphorylation	LSSFKTLSERESHVA HHHCCCHHHHHHHHH	39.58	25720772
195	Phosphorylation	SHVANCLSNNSSSPR HHHHHHHHCCCCCCC	35.84	29996109
198	Phosphorylation	ANCLSNNSSSPRNMT HHHHHCCCCCCCCHH	36.12	25720772
199	Phosphorylation	NCLSNNSSSPRNMTE HHHHCCCCCCCCHHH	46.62	25720772
200	Phosphorylation	CLSNNSSSPRNMTEF HHHCCCCCCCCHHHH	27.92	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of YO45_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of YO45_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of YO45_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
MMS2_SCHPO	mms2	physical	26771498

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of YO45_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200, AND MASSSPECTROMETRY.	18257517 [Abstract]