FRP2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FRP2_SCHPO
• UniProt AC: O94727
• Protein Name: Ferric/cupric reductase transmembrane component 2 {ECO:0000305}
• Gene Name: frp2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 564
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Metalloreductase responsible for reducing extracellular iron and copper prior to import (By similarity). Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores (By similarity). Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane (By similarity). Also participates in Cu(2+) reduction and Cu(+) uptake (By similarity)..
• Protein Sequence: MILARDDKWTLGSIALIFVLLIGFALLFLLERFRVKEKSRTFKDCVNVYQCPSKGERVYLALRHWFIFLATHKAQMTLILSPLVMLVTIPFTGKETKNSIASYDWNLTGVAARLGYLSCGLFFVSYFFSLKNNPFCLMLFSSHEKMNYLHRWLSVYAVLISVLHGILFMIFSAQSYKPLLYDKISIYGYFITVVLFLMTVASLPSVRRKFFEWFFVLHHTCSVLIIFLIWLHHPRTIVYMKACIIIYAFDRGCRLFRSIWNRSNFRIYLLNEDMIYMVGRKPKRSFFALPWAAGSHVYINIPSLSYWQVHPFTLASAPFDDFIELFVAVHSGFTERLANRLYSMPHEYPNFSLAPGTPESLSNTYRELNSFKSYAVEIENTAQGHTYEPEDLYLETTVFMDGPYGTTSNVFKEYSYVLLIAGGVGFSYTLPILRDLILKECNVTSITFIWSCRSLSLLKVASKSLNSLLHQSNVRLKIINHFTGSISCKESSEFSNQTTENSEMEFFDDRPDLDMYIQKFFDYVGYQTAALAACGSQSFLKRIKNSVNKSISSTTDIYQHYEEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
106	N-linked_Glycosylation	SIASYDWNLTGVAAR CHHHCCCCHHHHHHH	25.48	-
261	N-linked_Glycosylation	RLFRSIWNRSNFRIY HHHHHHHCCCCEEEE	35.51	-
350	N-linked_Glycosylation	SMPHEYPNFSLAPGT CCCCCCCCCCCCCCC	37.93	-
442	N-linked_Glycosylation	DLILKECNVTSITFI HHHHHHCCCCEEEEE	40.99	-
496	N-linked_Glycosylation	KESSEFSNQTTENSE CCCCHHCCCCCCCCC	48.84	-
548	N-linked_Glycosylation	KRIKNSVNKSISSTT HHHHHHHHCCCCCCC	31.98	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FRP2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FRP2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FRP2_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of FRP2_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.