CWC21_SCHPO - dbPTM
CWC21_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CWC21_SCHPO
UniProt AC O14161
Protein Name Pre-mRNA-splicing factor cwf21
Gene Name cwf21
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 293
Subcellular Localization Cytoplasm. Nucleus .
Protein Description Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity)..
Protein Sequence MSYNGIGLPTPRGSGTNGYVMRNLSHVKKYDKNTNLQSNRNAKALEKRVQDPSISEHECRRQIESKLLLYREQLLEEVSSQHSTDAAASDSNTNFGTENPKPPKAIIKDEQSQSKTKSLDEADVEILVQKYREQLLKELQLQKSTEKGKNFESILQPQKRKETRGFHSKNDDDGRLEERDDLRSSVDDDYYDYPRYSERKSLNSKRHVDNYNENRRRHYDSYSSYDELERRRSSNESYSRRSELPRRDYNRHDERERYSYHRRRERSNSPSYTKNESIPVVDRDSSPEGGEIV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
116PhosphorylationDEQSQSKTKSLDEAD
CHHHCCCCCCCCHHH		30.9825720772
118PhosphorylationQSQSKTKSLDEADVE
HHCCCCCCCCHHHHH		46.4128889911
184PhosphorylationEERDDLRSSVDDDYY
CCHHHHHHHCCCCCC		41.8525720772
267PhosphorylationYHRRRERSNSPSYTK
HHHHHHHCCCCCCCC		36.5925720772
269PhosphorylationRRRERSNSPSYTKNE
HHHHHCCCCCCCCCC		19.2325720772
272PhosphorylationERSNSPSYTKNESIP
HHCCCCCCCCCCCCC		25.7225720772
273PhosphorylationRSNSPSYTKNESIPV
HCCCCCCCCCCCCCC		31.5625720772
277PhosphorylationPSYTKNESIPVVDRD
CCCCCCCCCCCCCCC		41.4021712547
285PhosphorylationIPVVDRDSSPEGGEI
CCCCCCCCCCCCCCC		49.0028889911
286PhosphorylationPVVDRDSSPEGGEIV
CCCCCCCCCCCCCCC		31.1228889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CWC21_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CWC21_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CWC21_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PTPA1_SCHPOypa1genetic
18818364
YIQ4_SCHPOSPAC824.04genetic
18818364
YE8A_SCHPOSPAC9G1.10cgenetic
18818364
MCL1_SCHPOmcl1genetic
18818364
RSV2_SCHPOrsv2genetic
18818364
H2AZ_SCHPOpht1genetic
18818364
PAB2_SCHPOpab2genetic
18818364
YBPD_SCHPOSPBC16H5.13genetic
18818364
ELOC_SCHPOSPBC1861.07genetic
18818364
SWD2_SCHPOswd2genetic
18818364
COPE_SCHPOsec28genetic
18818364
YOU5_SCHPOpph3genetic
18818364
NGG1_SCHPOngg1genetic
18818364
VPS71_SCHPOvps71genetic
18818364
YB3C_SCHPOcay1genetic
18818364
PLMT_SCHPOcho1genetic
18818364
SWD3_SCHPOswd3genetic
18818364
EIF2A_SCHPOSPBC4B4.04genetic
18818364
PPK29_SCHPOppk29genetic
18818364
SUM2_SCHPOsum2genetic
18818364
HPC2_SCHPOhip4genetic
18818364
HEL2_SCHPOSPCC1223.01genetic
18818364
CAF1_SCHPOcaf1genetic
18818364
SDC1_SCHPOsdc1genetic
18818364
SET1_SCHPOset1genetic
18818364
CCR4_SCHPOccr4genetic
18818364
SPP1_SCHPOspf1genetic
18818364
CID12_SCHPOcid12genetic
18818364
AMO1_SCHPOamo1genetic
18818364
AIR1_SCHPOair1genetic
18818364
RYH1_SCHPOryh1genetic
22681890
G3P2_SCHPOgpd3genetic
22681890
RTF2_SCHPOrtf2genetic
22681890
LUB1_SCHPOlub1genetic
22681890
UBP8_SCHPOubp8genetic
22681890
YAC5_SCHPOcph1genetic
22681890
GOS1_SCHPOgos1genetic
22681890
YF48_SCHPOSPAC3H5.08cgenetic
22681890
CWF16_SCHPOcwf16genetic
22681890
NEM1_SCHPOnem1genetic
22681890
OTU2_SCHPOotu2genetic
22681890
ULP2_SCHPOulp2genetic
22681890
TRX2_SCHPOtrx2genetic
22681890
POM1_SCHPOpom1genetic
22681890
YBPC_SCHPOSPBC16H5.12cgenetic
22681890
RIA1_SCHPOria1genetic
22681890
PDAT_SCHPOplh1genetic
22681890
FSC1_SCHPOfsc1genetic
22681890
FSV1_SCHPOfsv1genetic
22681890
VPS38_SCHPOvps38genetic
22681890
YJD1_SCHPOSPCC594.01genetic
22681890
CYB51_SCHPOSPBC29A10.16cgenetic
22681890
POF3_SCHPOpof3genetic
22681890
YGVA_SCHPOdef1genetic
22681890
VPS3_SCHPOvps3genetic
22681890
ELP1_SCHPOelp1genetic
22681890
SET1_SCHPOset1genetic
22681890
SEC14_SCHPOspo20genetic
22681890
SUM2_SCHPOsum2genetic
22681890
H2AZ_SCHPOpht1genetic
22681890
PMT3_SCHPOpmt3genetic
22681890
TBA2_SCHPOatb2genetic
22681890
MID1_SCHPOmid1genetic
22681890
RHO3_SCHPOrho3genetic
22681890
DGAT2_SCHPOdga1genetic
22681890
YBD1_SCHPOSPBC16C6.01cgenetic
22681890
AREH2_SCHPOare2genetic
22681890
SEC6_SCHPOsec6physical
26771498
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CWC21_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118; SER-285 ANDSER-286, AND MASS SPECTROMETRY.

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