| UniProt ID | HEL2_SCHPO | |
|---|---|---|
| UniProt AC | Q76PD2 | |
| Protein Name | E3 ubiquitin-protein ligase hel2 {ECO:0000250|UniProtKB:Q05580} | |
| Gene Name | SPCC1223.01, SPCC285.18 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 732 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation.. | |
| Protein Sequence | MSPSGPNLNNKEHNRASEKKNSRTHNKKTNRNQSKEKPVSSRSVETPKNAVCLEPVGTDPVSNVATVDASKEEQDEDEQICFICAEGITYSCVLPCNHRMCHVCALRLRALYKTKECTFCKTEWDTVLITKDHEIDIHDVDLAKLPFQDEKLGIVYSDEHAQEESNLLLQFNCPEDACDITCKGWFDLKLHAKVKHHKFFCDLCVKNKKVFTHEHTLFSKKGLTKHNEVGDQGSDLEITGFKGHPKCEFCNTHFYDDDELFKHCREKHERCYICDQVAGRPTHQYFKNYDSLERHFEKDHYICRERECLERKFVVFGTEIDLKAHQLDEHPHNFTQRELREARRIIPQFSYDPPGASGRNRRERTSSTPSEQSTSVNETANSLSNLHLSRGEIAHLRQEEYVREQQARHRDFGFTLSNPAPTSARPATSTRTISRGKTRTLRNEDFPSLAEVANQNSSSAPSVPVSAPRLSGKSASRNHVPSPPKGTKSPMASSEQAQHQQVIDRMQKLTNYDDHKINDFKFAVSSFRGNVMPAREAVARITKLVAKPHEQLSGVFNQIANLLENKEKSRELLEAWQEWKILNAKDDTRIGTTNSNLLRLKRSNRTAAQTASVWNRIERAAAHDGPSLSAPSSSINLANITSRPTNSSAANTPSWGVRKARASALNARSEEDFPALPPSTSKRISVQLGKKQARPVDSWGSTPNTSSNRNSNTMGVSKKKNGKKQTVLFHIG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSPSGPNLN ------CCCCCCCCC | 24763107 | ||
| 212 | Phosphorylation | VKNKKVFTHEHTLFS ECCCCCEEECCCCCC | 21712547 | ||
| 216 | Phosphorylation | KVFTHEHTLFSKKGL CCEEECCCCCCCCCC | 21712547 | ||
| 234 | Phosphorylation | NEVGDQGSDLEITGF CCCCCCCCCCEECCC | 21712547 | ||
| 367 | Phosphorylation | NRRERTSSTPSEQST CCCCCCCCCCCCCCC | 27738172 | ||
| 370 | Phosphorylation | ERTSSTPSEQSTSVN CCCCCCCCCCCCCHH | 27738172 | ||
| 384 | Phosphorylation | NETANSLSNLHLSRG HHHHHHHHHCCCCHH | 27738172 | ||
| 482 | Phosphorylation | ASRNHVPSPPKGTKS CCCCCCCCCCCCCCC | 28889911 | ||
| 487 | Phosphorylation | VPSPPKGTKSPMASS CCCCCCCCCCCCCCH | 29996109 | ||
| 489 | Phosphorylation | SPPKGTKSPMASSEQ CCCCCCCCCCCCHHH | 21712547 | ||
| 627 | Phosphorylation | AAAHDGPSLSAPSSS HHHCCCCCCCCCCCC | 29996109 | ||
| 629 | Phosphorylation | AHDGPSLSAPSSSIN HCCCCCCCCCCCCEE | 27738172 | ||
| 632 | Phosphorylation | GPSLSAPSSSINLAN CCCCCCCCCCEECCC | 27738172 | ||
| 633 | Phosphorylation | PSLSAPSSSINLANI CCCCCCCCCEECCCC | 27738172 | ||
| 634 | Phosphorylation | SLSAPSSSINLANIT CCCCCCCCEECCCCC | 27738172 | ||
| 685 | Phosphorylation | PSTSKRISVQLGKKQ CCCCCCEEEECCCCC | 29996109 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HEL2_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HEL2_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HEL2_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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