ATG9_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATG9_SCHPO
• UniProt AC: O74312
• Protein Name: Autophagy-related protein 9
• Gene Name: atg9
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 702
• Subcellular Localization: Preautophagosomal structure membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Required for mitophagy. Cycles between the PAS and the cytoplasmic vesicle pool and may participate in supplying membrane for the growing autophagosome. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machineries are required for anterograde trafficking to the PAS during either the Cvt pathway or bulk autophagy and for retrograde trafficking (By similarity). Has a role in meiosis and sporulation..
• Protein Sequence: MFYQPAQNKKQYDDLADIEAQNNVPNTQEVLEAWQESLDSDEDESSPLEESNGFTISEHDDFVKSVPRKNNPTDLLYSGKLLDSDEPPSVHGNSSKVPSKHPSPSFPETTSLRNLQNGSKQKPALPNFNDPHFYNEDVTRSGHPNRSIYTQLPRNEFSNARVLWNRLSARDRVLWRWANVENLDSFLQQVYTYYTGKGLSCIIVHRLFQILTVSFVIGFTTFITSCIDWPAVTPHGSLAGVTKSQCIAQMSPITYLVLWLFLSFLLALWIYYLTDIPRLWQMREFYIHALKIATADMPTVSWQRVLYRLLKLKNVNALTAEDGRVVSLHNMKRLDAYAIANRIMRKDNYFIALINNGIINIELPLLHRRILTHTTEWNINWCIFNFVFDEQGQLRSAFRNPNSRKRLSEELRRRFIVAGFLNCLFAPIVAIYLVIHNFFRYFNEYHKNPGALSTRRYTPLALWTFREYNELQHFFDERINDSYAAASHYVSQFPDFNMIRLFKYISFILGSFTAILVIITVFDPELMVTFEITKDRSVLFYLGLFGSLIAVSRSIIPDETLVFAPEKALRRVITFTHYMPGWWSDNMHSKAVQQEFCSLYSYRIVNLLWEILGILLTPVLLFFTFPSCSQDIVDFFREHTINVEGVGYVCSYAVFQDNPPYESVASLVQSRKISPLIQNKPELSRISFYEQFNTEAPRRDLR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
78	Phosphorylation	NPTDLLYSGKLLDSD CCCCCEECCEECCCC	29.44	28889911
89	Phosphorylation	LDSDEPPSVHGNSSK CCCCCCCCCCCCCCC	37.14	24763107
95	Phosphorylation	PSVHGNSSKVPSKHP CCCCCCCCCCCCCCC	41.49	21712547
99	Phosphorylation	GNSSKVPSKHPSPSF CCCCCCCCCCCCCCC	46.73	21712547
103	Phosphorylation	KVPSKHPSPSFPETT CCCCCCCCCCCCCCC	32.66	24763107
110	Phosphorylation	SPSFPETTSLRNLQN CCCCCCCCCHHHCCC	24.89	21712547
327	Phosphorylation	AEDGRVVSLHNMKRL CCCCCEEEEECCCHH	22.51	21712547
480	N-linked_Glycosylation	HFFDERINDSYAAAS HHHHHHCCHHHHHHH	38.10	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATG9_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATG9_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATG9_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTL1_SCHPO	ctl1	physical	23950735

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.