| UniProt ID | AIR1_SCHPO | |
|---|---|---|
| UniProt AC | Q9P795 | |
| Protein Name | Protein air1 | |
| Gene Name | air1 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 315 | |
| Subcellular Localization | Nucleus, nucleolus. | |
| Protein Description | Component of the TRAMP (TRF4) and TRAMP5 complexes which have a poly(A) RNA polymerase activity and are involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met. Both complexes polyadenylate RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome.. | |
| Protein Sequence | MDMTVSNQKAESDDGSDIDDAALLQKINSLPIDQSITNSVSLEKHDFQGSDDHDSSTDLSDSTLEDVEGSEWADVSRGRYFGSDPSESIVCHNCKGNGHISKDCPHVLCTTCGAIDDHISVRCPWTKKCMNCGLLGHIAARCSEPRKRGPRVCRTCHTDTHTSSTCPLIWRYYVEKEHPVRIDVSEVRKFCYNCASDEHFGDDCTLPSRSNYPESTAFCEANCPSGNDASNKEFFETRRKEFQLERREQNRNQKSSKQRPFHKPGNSLASRLGSKPKSFKRKHSPPSEENGNLSFHSSDGRKFTKTSKKNRKRKW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 12 | Phosphorylation | VSNQKAESDDGSDID CCCCCCCCCCCCCCC | 45.95 | 28889911 | |
| 16 | Phosphorylation | KAESDDGSDIDDAAL CCCCCCCCCCCHHHH | 38.09 | 28889911 | |
| 29 | Phosphorylation | ALLQKINSLPIDQSI HHHHHHHCCCCCCHH | 38.71 | 29996109 | |
| 284 | Phosphorylation | KSFKRKHSPPSEENG CCCCCCCCCCCCCCC | 41.35 | 28889911 | |
| 287 | Phosphorylation | KRKHSPPSEENGNLS CCCCCCCCCCCCCEE | 62.01 | 29996109 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AIR1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AIR1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AIR1_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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