| UniProt ID | PP2C1_SCHPO | |
|---|---|---|
| UniProt AC | P40371 | |
| Protein Name | Protein phosphatase 2C homolog 1 | |
| Gene Name | ptc1 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 347 | |
| Subcellular Localization | ||
| Protein Description | It has a serine and threonine phosphatase activity. Has a specialized role in the heat shock response. May be responsible for the dephosphorylation of hsp90. Also has a role in maintaining osmotic stability.. | |
| Protein Sequence | MKGSHPNAGSLLEPLHKLNPFSENSTSGHRKNASDHSADGETRPIAIEMKDSKGNTVPVGNSRPSKASNWLAGLMEDKNQRWRRSMEDTHICLYDFGGNQDDGFVAVYDGHAGIQASDYCQKNLHKVLLEKVRNEPDRLVTDLMDETFVEVNSKIAKATHNDICGCTAAVAFFRYEKNRTRRVLYTANAGDARIVLCRDGKAIRLSYDHKGSDANESRRVTQLGGLMVQNRINGVLAVTRALGDTYLKELVSAHPFTTETRIWNGHDEFFIIACDGLWDVVSDQEAVDFVRNFVSPREAAVRLVEFALKRLSTDNITCIVVNLTRNPGDLDDSGLTADNDSYSNDYY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Phosphorylation | GSHPNAGSLLEPLHK CCCCCCCCCCHHHHH | 27.63 | 21712547 | |
| 34 | Phosphorylation | SGHRKNASDHSADGE CCCCCCCCCCCCCCC | 45.29 | 25720772 | |
| 37 | Phosphorylation | RKNASDHSADGETRP CCCCCCCCCCCCCCC | 32.80 | 24763107 | |
| 42 | Phosphorylation | DHSADGETRPIAIEM CCCCCCCCCCEEEEE | 47.47 | 25720772 | |
| 62 | Phosphorylation | NTVPVGNSRPSKASN CEEECCCCCCCHHHH | 39.37 | 27738172 | |
| 341 | Phosphorylation | GLTADNDSYSNDYY- CCCCCCCCCCCCCC- | 36.39 | 25720772 | |
| 342 | Phosphorylation | LTADNDSYSNDYY-- CCCCCCCCCCCCC-- | 17.85 | 25720772 | |
| 343 | Phosphorylation | TADNDSYSNDYY--- CCCCCCCCCCCC--- | 27.46 | 25720772 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PP2C1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PP2C1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PP2C1_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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