GGT2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GGT2_SCHPO
• UniProt AC: O14194
• Protein Name: Glutathione hydrolase proenzyme 2
• Gene Name: ggt2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 611
• Subcellular Localization: Vacuole membrane ; Single-pass type II membrane protein .
• Protein Description: Catalyzes the transfer of the gamma-glutamyl moiety of glutathione (GSH) and other gamma-glutamyl compounds to amino acids and peptides. Major GSH-degrading enzyme, catalyzing the hydrolytic release of L-glutamate from GSH. Plays a role in the turnover of the vacuolar GSH, serving as an alternative nitrogen source during nitrogen starvation (By similarity)..
• Protein Sequence: MSPTDTTPLLYSWDDQSRHQDPDWHKLRNYHGAWYRRISRRRFSQFIFAFGLMTLFVLVYSISSNLHTPTQFTGHKVRGRRGAVASEVPVCSDIGVSMLADGGNAVDAAIASTFCIGVVNFFSSGIGGGGFMLIKHPNETAQSLTFREIAPGNVSKHMFDKNPMLAQVGPLSIAIPGELAGLYEAWKSHGLLDWSKLLEPNVKLAREGFPVTRAMERVLKLPEMAHLLKDPIWQPILMPNGKVLRAGDKMFRPAYAKTLEIIANKGIEPFYRGELTNSMVKFIQDNGGIVTVEDFGNYSTVFADALHTSYRGHDVYTCTLPTSGPALIEGLNILDGYPLNTPSLAFPKRLHLEVEAMKWLSAGRTQFGDPDFLPLDHLDVVSKLLSKEFASQIRNNISLSKTYPWEHYNPSYDLPISHGTTHVSTVDSNNLAVSITSTVNLLFGSQLMDPVTGVVFNDQMDDFSIPGASNAFNLSPSPWNFIEPFKRPQSSSAPTILTDINGDFEMALGASGGSRIVTAVLDSIIKRIDMDYDIESMVASARPHHQLLPDILILESGFSKSVATRMKKYGHKVWRLKQHDTPLSQIQAVTRHHSEYYGMSDPRKYGQAAAY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSPTDTTPL ------CCCCCCCCC	36.19	21712547
11	Phosphorylation	TDTTPLLYSWDDQSR CCCCCCCCCCCCCCC	18.52	21712547
17	Phosphorylation	LYSWDDQSRHQDPDW CCCCCCCCCCCCCCH	38.43	21712547
138	N-linked_Glycosylation	FMLIKHPNETAQSLT EEEEECCCCCCCCEE	59.99	-
153	N-linked_Glycosylation	FREIAPGNVSKHMFD EEECCCCCHHHHHCC	33.55	-
297	N-linked_Glycosylation	VTVEDFGNYSTVFAD EEEEECCCCEEEEEE	27.81	-
396	N-linked_Glycosylation	FASQIRNNISLSKTY HHHHHHHCCCCCCCC	18.51	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GGT2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GGT2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GGT2_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of GGT2_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.