KEX1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KEX1_SCHPO
• UniProt AC: O60123
• Protein Name: Pheromone-processing carboxypeptidase kex1
• Gene Name: kex1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 510
• Subcellular Localization: Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Vacuole membrane ; Single-pass type I membrane protein .
• Protein Description: Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity)..
• Protein Sequence: MISKLLKIVLLTAGVIGNTLADSRIHEQYLVKAFPNEPVDYEGRMHAGHLNQTDQLDGDLFFWMFESVKPEYEHRSILWLNGGPGCSSEDGSLMEVGPFRLDDNNTFQLNPGRWDELGNLLFVDQPLGTGYSYSLAKDFQSNNEKMANDFSIFFEKFLEEFPERANDEWFIAGESFAGQYIPHIAAKLKEKNLVNLGGLAIGNGWINPLSHYETYLNYLVEKGMVDFESELGQYLHHSWAECLLAFDKIGSGSGDLSKCESFLGDILYMVSKEPGKACMNMYDISLESTYPTCGMDWPYDLSYLTEFLSTREAMTSLNVNLEKVHDWEECNDDVALQYAREGIESSSKLIQDLVSTVPILLFYGENDFLCNYLSGEKLTRSLEWNGAVGFQNQSAQPFYLPGYSDQPSGSYVSSRNLTFARIVEASHMVPYDHPNEMKTLITAFFNNDFASLPSVPKPSPDLGNGNYKWLYLGLIPVALTIIILFSIYLCRRFGLFGLSKQRYQPISPTP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	N-linked_Glycosylation	RMHAGHLNQTDQLDG CEECCCCCCCCCCCC	36.71	-
104	N-linked_Glycosylation	GPFRLDDNNTFQLNP CCEEECCCCCEECCC	49.46	-
392	N-linked_Glycosylation	NGAVGFQNQSAQPFY CCCCEECCCCCCCEE	35.20	-
416	N-linked_Glycosylation	GSYVSSRNLTFARIV CCCCCCCCEEEEEEE	45.43	-
507	Phosphorylation	KQRYQPISPTP---- CCCCCCCCCCC----	29.42	21712547
509	Phosphorylation	RYQPISPTP------ CCCCCCCCC------	34.54	24763107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KEX1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KEX1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KEX1_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of KEX1_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.