dbPTM

TPX1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TPX1_SCHPO
UniProt AC	O74887
Protein Name	Peroxiredoxin tpx1 {ECO:0000303\|PubMed:20356456}
Gene Name	tpx1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	192
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. [PubMed: 17409354]
Protein Sequence	MSLQIGKPAPDFKGTAVVNGAFEEIKLADYKGKWVFLGFYPLDFTFVCPTEIVAFSEAASKFAERNAQVILTSTDSEYSHLAFINTPRKEGGLGGINIPLLADPSHKVSRDYGVLIEDAGVAFRGLFLIDPKGVLRQITINDLPVGRSVDEALRLLDAFQFVEEHGEVCPANWHKGSDTIDTKNPEKYFSKH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
2	Phosphorylation	------MSLQIGKPA ------CCCCCCCCC	29996109
15	Phosphorylation	PAPDFKGTAVVNGAF CCCCCCCEEEECCCE	25720772
105	Phosphorylation	IPLLADPSHKVSRDY CCEECCCCCCCCCCC	28889911
148	Phosphorylation	NDLPVGRSVDEALRL CCCCCCCCHHHHHHH	15824112

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TPX1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TPX1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TPX1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TPX1_SCHPO	tpx1	physical	17409354
GPX1_SCHPO	gpx1	genetic	24316080
TRXB_SCHPO	trr1	genetic	24521463
CATA_SCHPO	ctt1	genetic	24521463
PMP20_SCHPO	pmp20	genetic	24521463
GPX1_SCHPO	gpx1	genetic	24521463
PRX_SCHPO	bcp1	genetic	24521463
TXL1_SCHPO	txl1	genetic	24268782

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TPX1_SCHPO

Related Literatures of Post-Translational Modification