PMD1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PMD1_SCHPO
• UniProt AC: P36619
• Protein Name: Leptomycin B resistance protein pmd1
• Gene Name: pmd1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1362
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: May be a transmembrane transporter of the mating factor, namely P-factor or M-factor. Confers resistance to leptomycin B and to several other antifungal drugs..
• Protein Sequence: MSLHSKKSTSTVKDNEHSLDLSIKSIPSNEKNFSTEKSENEASESHVVDVVKDPFEQYTPEEQEILYKQINDTPAKLSGYPRILSYADKWDIMLQLAGTITGIGAGLGMPLMSLVSGQLAQAFTDLASGKGASSFQHTVDHFCLYFIYIAIGVFGCSYIYTVTFIIAGERIARRIRQDYLHAILSQNIGYFDRLGAGEITTRITTDTNFIQDGLGEKVGLVFFAIATFVSGFVIAFIRHWKFTLILSSMFPAICGGIGLGVPFITKNTKGQIAVVAESSTFVEEVFSNIRNAFAFGTQDILAKLYNKYLITAQRFGINKAIAMGLMVGWMFFVAYGVYGLAFWEGGRLLHAGDLDVSKLIGCFFAVLIASYSLANISPKMQSFVSCASAAKKIFDTIDRVSPINAFTPTGDVVKDIKGEIELKNIRFVYPTRPEVLVLDNFSLVCPSGKITALVGASGSGKSTIIGLVERFYDPIGGQVFLDGKDLRTLNVASLRNQISLVQQEPVLFATTVFENITYGLPDTIKGTLSKEELERRVYDAAKLANAYDFIMTLPEQFSTNVGQRGFLMSGGQKQRIAIARAVISDPKILLLDEATSALDSKSEVLVQKALDNASRSRTTIVIAHRLSTIRNADNIVVVNAGKIVEQGSHNELLDLNGAYARLVEAQKLSGGEKDQEMVEEELEDAPREIPITSFGDDDEDNDMASLEAPMMSHNTDTDTLNNKLNEKDNVVFEDKTLQHVASEIVPNLPPADVGELNEEPKKSKKSKKNNHEINSLTALWFIHSFVRTMIEIICLLIGILASMICGAAYPVQAAVFARFLNIFTDLSSTDFLHKVNVFAVYWLILAIVQFFAYAISNFAMTYAMEAVLQRIRYHLFRTLLRQDVEFFDRSENTVGAITTSLSTKIQSLEGLSGPTLGTFFQILTNIISVTILSLATGWKLGLVTLSTSPVIITAGYYRVRALDQVQEKLSAAYKESAAFACESTSAIRTVASLNREENVFAEYCDSLIKPGRESAIASLKSGLFFSAAQGVTFLINALTFWYGSTLMRKGEYNIVQFYTCFIAIVFGIQQAGQFFGYSADVTKAKAAAGEIKYLSESKPKIDTWSTEGKKVESLQSAAIEFRQVEFSYPTRRHIKVLRGLNLTVKPGQFVAFVGSSGCGKSTTIGLIERFYDCDNGAVLVDGVNVRDYNINDYRKQIALVSQEPTLYQGTVRENIVLGASKDVSEEEMIEACKKANIHEFILGLPNGYNTLCGQKGSSLSGGQKQRIAIARALIRNPKILLLDEATSALDSHSEKVVQEALNAASQGRTTVAIAHRLSSIQDADCIFVFDGGVIAEAGTHAELVKQRGRYYELVVEQGLNKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	TVKDNEHSLDLSIKS CCCCCCCCEEEEEEE	19.87	28889911
22	Phosphorylation	NEHSLDLSIKSIPSN CCCCEEEEEEECCCC	27.86	24763107
25	Phosphorylation	SLDLSIKSIPSNEKN CEEEEEEECCCCCCC	37.75	24763107
28	Phosphorylation	LSIKSIPSNEKNFST EEEEECCCCCCCCCC	56.82	24763107
34	Phosphorylation	PSNEKNFSTEKSENE CCCCCCCCCCCCCCC	45.08	21712547
35	Phosphorylation	SNEKNFSTEKSENEA CCCCCCCCCCCCCCC	43.21	24763107
38	Phosphorylation	KNFSTEKSENEASES CCCCCCCCCCCCCCC	39.15	24763107
43	Phosphorylation	EKSENEASESHVVDV CCCCCCCCCCCCCEE	33.19	24763107
45	Phosphorylation	SENEASESHVVDVVK CCCCCCCCCCCEECC	21.06	21712547
705	Phosphorylation	DEDNDMASLEAPMMS CCCCCCCHHHHCCCC	21.80	29996109
736	Phosphorylation	NVVFEDKTLQHVASE CEEECCHHHHHHHHH	43.93	21712547
742	Phosphorylation	KTLQHVASEIVPNLP HHHHHHHHHHCCCCC	27.11	24763107
1210	Phosphorylation	EPTLYQGTVRENIVL CCCCCCCCCCCCEEE	10.81	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PMD1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PMD1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PMD1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAD55_SCHPO	rad55	genetic	23365689
DAD3_SCHPO	dad3	genetic	23365689
YEY5_SCHPO	cor1	genetic	24059229

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.